Clinical trials
Surgical clinical trials
Below are recruiting surgical clinical trials, each written for real people, not researchers. We’re tracking 1,180 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05647265RecruitingPhase 2
Immunotherapy before surgery for sarcomatoid pleural mesothelioma
This trial tests adding immunotherapy before surgery to help patients with sarcomatoid pleural mesothelioma. The goal is to shrink or control the cancer and make surgery possible, while checking safety.
Anchorage, AlaskaAges 18 years+ - NCT05672849Recruiting
Testing devices used during fetal surgery for spina bifida
This trial looks at how safe and effective certain surgical devices are when doctors perform a minimally invasive fetal procedure to repair a neural tube defect. If you choose this specific type of fetal surgery, you may be able to join the study to help improve care for future patients.
Houston, TexasAges 18 years+ - NCT05626114RecruitingPhase 2
Study of a lab-made eye treatment after subretinal surgery
This Phase 2 study tests OpRegen, a treatment delivered during special eye surgery, for geographic atrophy related to age-related macular degeneration (GA from AMD). It also includes an imaging “substudy” that uses detailed pictures of your retina to better track safety and activity.
Beverly Hills, CaliforniaAges 50 years+ - NCT05559411Recruiting
Tests ways to find different breast lesions before surgery
This trial looks at different methods doctors can use to locate a breast lesion using imaging, so it can be removed accurately during breast-conserving surgery. It may help your care team choose the best localization approach for your type and location of lesion.
LübeckAges 18 years+ - NCT05571722RecruitingPhase 4
Antibiotic prevention for surgical site infections
This trial tests whether using linezolid or vancomycin before surgery can better prevent infections at the surgical wound in people at higher risk. You might be considered because you either can’t take certain standard antibiotics (beta-lactams) and/or may carry MRSA bacteria.
MarseilleAges 18 years+ - NCT05575323Recruiting
Same-day radiation and stabilization for spine metastases
This trial tests whether giving focused radiation (SBRT) on the same day as spine surgery to stabilize the spine helps control symptoms from spinal metastases. It may help reduce pain and improve stability, especially when tumors threaten or affect the spine’s strength.
UtrechtAges 18 years+ - NCT05564494Recruiting
Surgery for repeat shoulder dislocations
This trial studies surgical treatment for people whose shoulder keeps dislocating forward (anteriorly). It may help by choosing a surgery plan for the amount of bone loss seen on scans, while excluding people with certain medical or instability patterns.
New York, New YorkAges 16–40 - NCT05569681Recruiting
Two blood-thinner schedules for clot prevention in very obese surgery patients
This study compares two different schedules of bemiparin (a blood thinner) to prevent dangerous blood clots after surgery in people with very high body weight. It may help find the safest and most effective dose/timing for clot prevention around the time of surgery.
Erbil, Kurdistan RegionAges 18–90 - NCT05535166RecruitingPhase 2
Risk- and lab-guided treatment for young children with medulloblastoma
This Phase 2 trial tests how doctors choose treatment for infants and young children with newly diagnosed medulloblastoma, based on MRI/CSF staging and lab testing of the tumor. It may help by matching therapy intensity to the child’s specific risk level and tumor type.
Palo Alto, CaliforniaAges Up to 4.9 years - NCT05516628RecruitingPhase 2
Adjuvant atezolizumab plus bevacizumab after liver cancer surgery
This trial studies whether adding atezolizumab and bevacizumab after complete liver cancer surgery can lower the chance the cancer comes back. It also uses “multi-omics” tests (special lab tests on your tissue/blood) to help predict who is more likely to respond or resist treatment.
SingaporeAges 21–90 - NCT05545007Recruiting
Pre-op vs post-op focused radiation for large brain metastases
This study compares giving focused, high-dose radiation before surgery versus after surgery for people with large brain metastases. The goal is to see which timing works best to control the tumors and help neurological outcomes.
Brescia, BresciaAges 18 years+ - NCT05517811Recruiting
Blood clotting tests before and after surgery for cancer
This study looks at how cancer and surgery affect blood clotting. It may help doctors understand and prevent blood clots in patients having surgery for certain cancers.
Aurora, ColoradoAges 18–99 - NCT05533528Recruiting
Save gum tissue in surgery for severe periodontitis
This trial studies a way to preserve gum (periodontal) “granulation” tissue during surgical treatment for severe periodontitis (gum disease). It may help patients heal better after surgery, especially when deep gum pockets do not improve after non-surgical care.
MurciaAges 18 years+ - NCT05545930Recruiting
Testing a sponge device to help blood recovery after heart surgery
This study looks at a new surgical sponge and blood-recovery device during major heart or lung operations. It aims to improve how efficiently blood is recovered and returned, which may help during surgery.
Cleveland, OhioAges 18–89 - NCT05546827RecruitingPhase 2
Pre-surgery radiation plus immunotherapy for mucosal melanoma
This Phase 2 trial tests giving radiation and immunotherapy before surgery for mucosal melanoma in the nose/sinuses or rectum. It may help shrink the tumor and improve outcomes while aiming to control the disease locally and in nearby areas.
Houston, TexasAges 18 years+ - NCT05526417Recruiting
Prehab program before treatment for deep leg soft tissue cancer
This trial tests an individualized “prehab” program (exercises and preparation before treatment) to improve recovery and surgical outcomes for adults with deep soft tissue sarcoma in the leg. It’s meant to help your body be as ready as possible for radiotherapy and surgery.
Scottsdale, ArizonaAges 18 years+ - NCT05461157Enrolling by invitation
Silicone ointment before head or neck surgery to improve healing
This trial studies whether applying a silicone ointment before and around the time of planned head or neck surgery can improve how your wound heals after surgery. It may help reduce problems like poor scar healing, but you can only join if you meet specific medical and safety requirements.
New Haven, ConnecticutAges 18 years+ - NCT05417685Enrolling by invitation
Digital physical therapy for musculoskeletal pain
This trial studies a smartphone/tablet-based care program to help people with neck, back, shoulder, elbow, wrist/hand, hip, knee, or ankle pain. It may help reduce pain and improve function using guided exercises, as long as it is safe for you to do light-to-moderate activity.
Draper, UtahAges 18 years+ - NCT05429099Recruiting
Planning study for jaw reconstruction surgery
This study helps teams plan surgery for people who need part of the lower jaw removed and rebuilt using special tissue flaps. It mainly looks at whether having specific pre-surgery CT images is possible and useful for reconstruction planning.
Vancouver, British ColumbiaAges 18 years+ - NCT05423210RecruitingEarly Phase 1
Atezolizumab with pre-surgery brain radiation for glioblastoma
This early-phase study tests atezolizumab (an immune therapy) together with radiation before brain surgery for glioblastoma. It aims to make the treatment safer and more effective before the tumor is removed.
Stony Brook, New YorkAges 18 years+ - NCT05447559RecruitingPhase 4
Testing how long to give antibiotics after heart surgery
This study looks at how long patients should receive an antibiotic after certain types of heart surgery, to help prevent infections. It may help find the best “duration” of antibiotic prophylaxis after surgery through the breastbone (median sternotomy).
Dallas, TexasAges 18 years+ - NCT04966663RecruitingPhase 2
Using blood DNA tests to guide lung cancer treatment
This study uses a blood test called ctDNA to look for leftover lung cancer after surgery. Based on that result, the trial will help decide which treatment approach is best for you and may catch cancer returning earlier.
Toronto, OntarioAges 18 years+ - NCT05388773RecruitingPhase 2
Surgery then lower-dose radiation for p16+ throat cancer
This Phase 2 study tests whether removing the tumor through the mouth, followed by a reduced course of radiation, can control HPV-related (p16+) oropharynx throat cancer. It may help reduce treatment intensity after surgery, while still aiming to keep the cancer from coming back.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05364879Recruiting
Exercise before ovarian cancer surgery
This trial tests whether supervised exercise (before surgery) can help people with advanced ovarian cancer get ready for treatment. It’s meant to improve readiness and safety during the time leading up to surgery.
Halifax, Nova ScotiaAges 18 years+
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Common questions
- Are there clinical trials for surgical?
- Yes. Clin2 currently lists 1,180 recruiting surgical studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a surgical trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a surgical trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.