Clinical trials
Tolerance clinical trials
Below are recruiting tolerance clinical trials, each written for real people, not researchers. We’re tracking 952 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07433556RecruitingPhase 1
Testing a new stomach acid drug in healthy adults
This phase 1 trial tests a new medicine called IY-828026 in healthy volunteers to see how safe it is and how the body processes it. It's a first step to find the right dose and check for side effects.
SeoulAges 19–50 - NCT07439120RecruitingEarly Phase 1
Testing a new radioactive drug for advanced solid tumors
This trial tests a new radioactive drug called 68Ga/177Lu-BRP-020063 in people with advanced solid tumors, especially bladder or breast cancer. The drug seeks out Nectin-4 on cancer cells, helping doctors see and potentially treat the tumors. The goal is to check that the drug is safe and tolerable.
ShanghaiAges 18 years+ - NCT07440147Recruiting
Akkermansia and Berberine for night shift workers' insulin sensitivity
This trial tests whether taking a probiotic called Akkermansia muciniphila and a natural plant compound called berberine can improve how your body uses insulin. If you work night shifts regularly, this study may help you find a way to support your metabolic health.
Graz, StyriaAges 21 years+ - NCT07442097Recruiting
Safety of a nutritional supplement in healthy older adults
This study tests a nutritional supplement (N-acetyl-L-cysteine and glycine) to see if it is safe and well-tolerated in healthy older adults. It may help if you are looking for ways to support your health as you age.
Pune, MaharashtraAges 60–80 - NCT07448740Recruiting
Stepwise milk protein introduction after failed challenge
This study looks at a gradual method of introducing heated milk proteins to children who previously had a reaction to unheated cow's milk. It aims to help build tolerance over time.
BonheidenAges 1–18 - NCT07449572RecruitingPhase 1
Safety study of HT31-1 for healthy volunteers
This trial tests a new drug called HT31-1 to see if it's safe in healthy people. It looks at how the drug moves in your body and if it causes side effects. This is a first step before testing it in patients with ARDS (a serious lung condition).
Richmond, VirginiaAges 18–65 - NCT07451613RecruitingPhase 1/Phase 2
Stem cell therapy trial for Huntington's disease
This trial tests whether human neural stem cells are safe and tolerable for people with Huntington's disease. It involves a neurosurgical procedure to inject the cells into the brain, along with MRI scans and other monitoring.
Irvine, CaliforniaAges 18–65 - NCT07461220RecruitingPhase 1/Phase 2
Testing IRL757 for apathy in Parkinson's disease
This trial tests a new drug called IRL757 to see if it is safe and helps with apathy (loss of motivation or interest) in people with Parkinson's disease. You need to have at least moderate apathy and a caregiver who can come to visits with you.
PlevenAges 50–90 - NCT07469085RecruitingPhase 1
Safety study of SV003 in healthy volunteers
This trial tests a new medication called SV003 in healthy people to see if it's safe and how the body processes it. You may be able to join if you are in good health and meet certain weight and lifestyle requirements.
ShanghaiAges 18–45 - NCT07470593Recruiting
Monitoring glucose to detect early pancreatic islet graft loss
This study uses a continuous glucose monitor (CGM) to watch for early signs that a transplanted pancreatic islet graft may be losing function. The goal is to catch problems sooner and help keep the transplant working well.
StrasbourgAges 18 years+ - NCT07474545RecruitingPhase 1
Safety study of KL0011034 injection in healthy volunteers
This trial tests a new injection called KL0011034 to see if it is safe and how the body processes it. Healthy volunteers aged 18–45 who meet specific health and lifestyle criteria can join.
Changsha, HunanAges 18–45 - NCT07476586RecruitingPhase 1
Study of GenSci161 safety in healthy adults
This trial tests a new medicine called GenSci161 to see if it is safe and how the body handles it. It is for healthy volunteers aged 18 to 45 who are willing to follow study rules and use birth control.
Shanghai, Shanghai MunicipalityAges 18–45 - NCT07477119RecruitingPhase 4
Personalized linezolid dosing for drug-resistant TB treatment
This trial tests whether adjusting the dose of linezolid based on regular blood tests can help people with multidrug-resistant tuberculosis (MDR-TB) tolerate the medication better while on the BPaL or BPaL-M regimen. It aims to reduce side effects and improve treatment success.
ConakryAges 15 years+ - NCT07477587RecruitingPhase 1
Comparing two myeloma treatments for new patients
This trial tests a new drug combination (HLX15-SC) against an approved treatment (DARZALEX FASPRO) along with lenalidomide and dexamethasone for people newly diagnosed with multiple myeloma who cannot have a stem cell transplant.
Springdale, ArkansasAges 18 years+ - NCT07478744RecruitingPhase 2
Study for generalized anxiety disorder with SYT-510
This trial tests a new medicine called SYT-510 for adults with generalized anxiety disorder who are not currently taking medication. It aims to see if the drug reduces anxiety and is safe.
LondonAges 18–55 - NCT07486115RecruitingPhase 1
Testing safety of BI 3814916 in healthy volunteers
This trial tests how safe and tolerable different doses of the study drug BI 3814916 are in healthy adults. It helps find the right dose for future studies.
EdegemAges 18–65 - NCT07673809RecruitingPhase 1/Phase 2
Gene therapy trial for Duchenne muscular dystrophy in young boys
This trial tests a gene therapy called GNR-097 for boys with Duchenne muscular dystrophy (DMD). The therapy aims to help improve muscle function, and the study will check how safe and effective it is.
MinskAges 4–9 - NCT07672756RecruitingPhase 1
Testing PL54 injection for adults with PKU
This study tests a new injection called PL54 to see if it is safe and tolerable for adults with phenylketonuria (PKU), a condition where the body cannot break down an amino acid called phenylalanine. It is designed for people with high blood phenylalanine levels and may offer a new treatment option.
Hefei, AnhuiAges 18–55 - NCT06674694RecruitingPhase 1
Testing brexpiprazole long-acting shot for schizophrenia
This study tests an injectable form of brexpiprazole that stays in the body for a long time. It aims to see if the shot is safe and tolerable for healthy volunteers and people with schizophrenia, and how the body processes it.
Beijing, Beijing MunicipalityAges 18–65 - NCT07660731RecruitingPhase 1
Testing a new asthma medicine in healthy people and those with asthma
This study tests different doses of a new medicine (PF-08103402) to see how well it is tolerated and how it works in both healthy adults and adults with mild to moderate asthma. It helps researchers find the right dose for future studies.
New Haven, ConnecticutAges 18–65 - NCT07486817RecruitingPhase 2
Testing zongertinib with chemo and immunotherapy for advanced lung cancer
This trial tests a new drug called zongertinib combined with chemotherapy, with or without pembrolizumab (an immunotherapy), for people with advanced non-small cell lung cancer that has a specific change in the HER2 gene. The goal is to see how safe and well-tolerated the combination is.
St Leonards, New South WalesAges 18 years+ - NCT07487376RecruitingPhase 1
A single-dose study of IBIO-600 in healthy overweight or obese adults
This trial tests a single dose of an experimental treatment called IBIO-600 to see if it's safe and how it works in overweight or obese adults. It's for people who are generally healthy and have a stable weight, without diabetes.
Bayswater, VictoriaAges 18–65 - NCT07495215RecruitingPhase 1/Phase 2
Personalized mRNA vaccine plus immunotherapy for liver cancer after surgery
This trial tests a personalized mRNA vaccine (iNeo-Vac-R01) combined with a PD-1 inhibitor to prevent liver cancer from coming back after surgery. It is for people with early-stage liver cancer who have a high risk of recurrence.
Hangzhou, ZhejiangAges 18–75 - NCT07500181RecruitingPhase 1
Testing the safety of a new antibiotic in healthy adults
This trial tests an investigational antibiotic called BAL2420 to see if it is safe and how the body processes it. Healthy volunteers are needed to help determine the right dose before it can be studied in people with infections.
GroningenAges 18–55
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Common questions
- Are there clinical trials for tolerance?
- Yes. Clin2 currently lists 952 recruiting tolerance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tolerance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tolerance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.