Clinical trials
Tolerance clinical trials
Below are recruiting tolerance clinical trials, each written for real people, not researchers. We’re tracking 952 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07500506RecruitingPhase 3
Safety of a fifth dose of the Lyme disease vaccine
This study is for people who have already received four doses of the Lyme vaccine (VLA15) in a previous study. It tests whether a fifth dose is safe and helps the body build more protection against Lyme disease.
Bangor, MaineAges 7 years+ - NCT07501455Recruiting
Studying toothpaste and mouth rinse effects on gum inflammation
This study tests whether using a certain toothpaste and mouth rinse can reduce gum inflammation (gingivitis) better than brushing alone. It is for people with mild to moderate gum disease who have not used tobacco or certain medications recently.
Somerville, MassachusettsAges 18–60 - NCT07510061Recruiting
How your body handles mild heat
This study looks at how your body responds to mild heat depending on where you live and your specific traits. If you are a healthy adult in Denmark or Greece, you may be able to help researchers understand differences in heat resilience.
CopenhagenAges 18–65 - NCT07511205RecruitingPhase 1
Study of AZD1043 for overweight or obesity
This trial tests a new medicine called AZD1043 in healthy adults who are overweight or have obesity. It aims to see if the medicine is safe and how the body handles it.
Glendale, CaliforniaAges 18–65 - NCT07514260RecruitingPhase 1
Safety study of ABBV-295 injections in Japanese adults with overweight
This is an early-stage safety study testing a new injectable medication (ABBV-295) in healthy Japanese adults who are overweight or have obesity. The study measures how well the body tolerates the drug and how it moves through the body.
Anaheim, CaliforniaAges 18–65 - NCT07516405RecruitingPhase 1
Psilocybin Safety Study in Older Adults
This research tests whether psilocybin (a psychoactive compound from certain mushrooms) is safe and well-tolerated in healthy people aged 65–85. Researchers want to understand how older adults respond to this substance and whether it could be useful for future treatments.
San Francisco, CaliforniaAges 65–85 - NCT07521345RecruitingPhase 1
Safety Study of HSK55879 Tablet in Healthy Adults
This early-stage study tests how a new experimental medication (HSK55879) is tolerated and processed by the body in healthy volunteers. Researchers will also check how food affects the drug's absorption to help determine safe dosing for future patient studies.
Hefei, AnhuiAges 18–45 - NCT07522970RecruitingPhase 1
Safety and Tolerability Study of LG-0317 in Healthy Adults
This early-stage study tests a new experimental drug called LG-0317 in healthy volunteers to see if it is safe and how the body processes it. If you are healthy and meet the basic requirements, this trial may help advance a new treatment option.
Shanghai, Shanghai MunicipalityAges 18–45 - NCT07526194RecruitingPhase 1
Testing a New Drug's Safety in Healthy Men
This study tests how well healthy men tolerate different doses of a new experimental medication called BI 3821001. Researchers will monitor your body's response to see if the drug is safe and how your body handles it.
BerlinAges 18–55 - NCT07527221RecruitingPhase 1
Safety study of ZE74-0282 in healthy adults
This is an early-stage safety study testing a new experimental drug called ZE74-0282 in healthy volunteers. Researchers want to learn how safe the drug is and how well people tolerate it before testing it in patients with a disease.
Randwick, New South WalesAges 18–55 - NCT07535099RecruitingPhase 1
Safety study of ICP-538 in healthy volunteers
This trial tests a new drug called ICP-538 in healthy people to see how safe it is and how the body processes it. It is an early-phase study that helps decide if the drug can move to testing in patients with a specific condition.
Beijing, Beijing MunicipalityAges 18–50 - NCT07538128RecruitingEarly Phase 1
New drug YSCH-01 with immunotherapy for recurrent brain cancer
This early-stage trial tests a new drug called YSCH-01, alone or combined with an immunotherapy drug (atezolizumab), for glioblastoma that has come back after previous treatment. The study places a small tube in the brain to deliver the drug directly and monitors safety and how well it works.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT07540910RecruitingPhase 1
Safety study of EDP-978 in healthy adults
This is an early-stage study testing a new experimental drug called EDP-978 in healthy volunteers to see if it is safe and how the body processes it. Researchers will give participants single or multiple doses and monitor for side effects and how the drug moves through the body.
San Antonio, TexasAges 18–65 - NCT07549919RecruitingPhase 1
Food Effects on a New Experimental Drug in Healthy Men
This study tests how food affects how the body absorbs and processes a new experimental drug called AJ201. Researchers will give the drug to healthy men with and without food to see if it makes a difference, and they'll check for any side effects.
Los Alamitos, CaliforniaAges 18–55 - NCT07554222RecruitingPhase 1
Safety study of IBI3013 for vitiligo and hair loss
This is an early-stage safety study of a new drug called IBI3013. The trial tests how safe the drug is and how your body processes it. It enrolls healthy volunteers first, then people with vitiligo (loss of skin color) or severe alopecia areata (patchy hair loss).
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07554287Recruiting
Leg vs. Arm Exercise for Gestational Diabetes Management
This study tests whether exercising with your legs or arms helps manage blood sugar levels during pregnancy if you have gestational diabetes. The goal is to see which type of exercise works better and how it affects your overall health and stress during pregnancy.
Lahore, Punjab ProvinceAges 18–35 - NCT07554365RecruitingPhase 1
Safety Study of AN01 Inhaled Powder in Healthy Adults
This early-stage trial tests whether AN01, a new inhaled powder medication, is safe and well-tolerated in healthy people. Researchers will measure how the body processes the drug and watch for any side effects.
Adelaide, South AustraliaAges 18–60 - NCT07554495RecruitingPhase 3
Filgotinib for moderate to severe polyarticular juvenile arthritis
This trial tests filgotinib, a new medication that may help reduce joint swelling and pain in children and teens (ages 8–17) with polyarticular juvenile idiopathic arthritis—a type of childhood arthritis affecting multiple joints. You're eligible if your current arthritis medicines haven't worked well enough.
LeuvenAges 8–18 - NCT07558538RecruitingEarly Phase 1
Inhaled Growth Factor Treatment for Severe Lung Failure
This early-stage trial tests whether an inhaled medication called recombinant human keratinocyte growth factor-2 (rh-KGF-2) can help patients with acute respiratory distress syndrome (ARDS)—a serious condition where the lungs cannot deliver enough oxygen to the blood. The drug is designed to help repair lung tissue damage.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07560943RecruitingPhase 1
AI-Designed Cancer Vaccine for Advanced Solid Tumors
This trial tests a new mRNA vaccine designed by artificial intelligence to treat advanced cancers that have stopped responding to standard chemotherapy. The vaccine is personalized to each patient's tumor and aims to help the immune system fight remaining cancer cells.
Chengdu, SichuanAges 18–70 - NCT07564739Recruiting
Cold Plasma Treatment for Long-Lasting Wound Healing
This study tests whether a special cold plasma treatment (a type of energized gas) can safely help heal chronic wounds that haven't improved after several weeks. Cold plasma may help clean wounds and reduce bacteria, potentially speeding up healing.
OrléansAges 18 years+ - NCT07570147RecruitingPhase 1
Safety study of ABBV-1451 infusions and injections in healthy adults
This early-stage trial tests how the body handles a new experimental drug called ABBV-1451, given as either an infusion (IV drip) or injection. Researchers want to make sure it's safe and well-tolerated in healthy volunteers before testing it in people with medical conditions.
Grayslake, IllinoisAges 18–60 - NCT07570758RecruitingPhase 2
Testing ERX1000 to Help Adults Manage Obesity
This study tests whether a new medication called ERX1000 is safe and well-tolerated in adults with obesity. The trial will help doctors understand if this treatment could be helpful for weight management.
Louisville, KentuckyAges 18–60 - NCT07572825RecruitingPhase 1
Safety study of NMN supplement for DHDDS-CDG
This trial tests whether a supplement called NMN is safe and well-tolerated in children and adults with a rare genetic condition called DHDDS-CDG. NMN may help support cellular energy and protein production, which are affected by this condition.
New York, New YorkAges 4 years+
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Common questions
- Are there clinical trials for tolerance?
- Yes. Clin2 currently lists 952 recruiting tolerance studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tolerance trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tolerance trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.