Clinical trials · Colorado
Total Knee Arthroplasty clinical trials in Colorado
We’re tracking 8 recruiting total knee arthroplasty studies with a site in Colorado — including Phase 1/Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Colorado
- NCT07286513Enrolling by invitation
Study of a new knee replacement implant
This study follows patients who receive a specific type of knee replacement implant called the Persona® SoluTion® PPS, to see how well it works over time. If your surgeon recommends this implant and you meet standard health requirements, you may be able to join.
Denver, ColoradoAges 18 years+ - NCT06108063RecruitingPhase 1/Phase 2
Losartan to prevent knee stiffness after replacement
This study tests whether losartan, a blood pressure medicine, can prevent excessive scar tissue (arthrofibrosis) after a total knee replacement. Participants receive losartan or a placebo for 6 months after surgery to see if it improves knee motion and reduces stiffness.
Vail, ColoradoAges 18 years+ - NCT05288803Recruiting
Personalized rehab plans for veterans after knee replacement
This study tests whether customizing a recovery plan (“trajectory”) can improve rehabilitation for veterans after total knee replacement surgery. You may be eligible if you start outpatient rehab soon after surgery at participating clinics.
Aurora, ColoradoAges 40–90 - NCT05653102Recruiting
Collecting data on a knee replacement system after surgery
This study collects real-world health and surgery records to better understand how the Truliant total knee replacement performs. It may help doctors and patients by improving future guidance on this knee system’s safety and effectiveness.
Aurora, ColoradoAges 18 years+ - NCT06953375Recruiting
Electrical stimulation for faster recovery after knee replacement
This study tests if adding a gentle electrical stimulation (called NMES) to standard physical therapy helps people recover strength faster after knee replacement surgery. It is for patients who go to specific UCHealth or Intermountain Health therapy clinics after their first total knee replacement.
Aurora, ColoradoAges 18 years+ - NCT07485803RecruitingPhase 4
Methadone for pain after knee replacement
This study tests whether methadone, a type of pain medicine, helps control pain better after knee replacement surgery. It is for people who have not used narcotics recently and are otherwise healthy.
Denver, ColoradoAges 21–75 - NCT07213778RecruitingPhase 3
Comparing a new drug to aspirin for blood clot prevention after knee replacement
This trial tests a new medicine called REGN7508 against aspirin to prevent blood clots after total knee replacement surgery. It may help if you are having a planned knee replacement and are in good health.
Lone Tree, ColoradoAges 18 years+ - NCT07015905RecruitingPhase 3
Study of REGN7508 vs. standard blood thinners after knee replacement
This trial compares a new blood thinner called REGN7508 to two standard blood thinners (apixaban and enoxaparin) to prevent blood clots after total knee replacement surgery. The goal is to see which is safer and more effective.
Englewood, ColoradoAges 18 years+
Total Knee Arthroplasty trials by city in Colorado
Where these studies are running in Colorado
Institutions with a site for the recruiting total knee arthroplasty studies listed above.
- AdventHealth Porter
- Denver Hip and Knee, Inc.
- Denver Metro Orthopedics, P.C.
- Rocky Mountain Regional VA Medical Center
- Sky Ridge Medical Center
- Steadman Philippon Research Institute
- UCHealth
- UCHealth University of Colorado Hospital
What taking part in a total knee arthroplasty study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Total Knee Arthroplasty trials in other states
Common questions
- Are there total knee arthroplasty clinical trials in Colorado?
- Yes. We're currently tracking 8 recruiting total knee arthroplasty studies with a site in Colorado, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a total knee arthroplasty study in Colorado?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Colorado to take part?
- Not necessarily. These studies have a site in Colorado, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a total knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New total knee arthroplasty studies open in Colorado regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.