Clinical trials · California
Total Knee Arthroplasty clinical trials in California
We’re tracking 9 recruiting total knee arthroplasty studies with a site in California — including Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07584915Enrolling by invitationPhase 4
Pain Relief Method Comparison for Knee Replacement Surgery
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Los Angeles, CaliforniaAges 18 years+ - NCT07767097Recruiting
Low-dose radiation after revision knee replacement for stiffness
This study tests whether a single low dose of radiation after revision knee replacement surgery can help reduce stiffness and improve knee movement in people who had a stiff knee after their first replacement. The radiation is given along with usual care after surgery.
Los Angeles, CaliforniaAges 18 years+ - NCT07213778RecruitingPhase 3
Comparing a new drug to aspirin for blood clot prevention after knee replacement
This trial tests a new medicine called REGN7508 against aspirin to prevent blood clots after total knee replacement surgery. It may help if you are having a planned knee replacement and are in good health.
La Mesa, CaliforniaAges 18 years+ - NCT06080152Recruiting
Wheeled device use after knee replacement
This study observes how people use wheeled devices (like walkers) after a total knee replacement. It helps doctors understand what patients need during recovery.
Redwood City, CaliforniaAges 18–99 - NCT07282782RecruitingPhase 4
Vancomycin for knee replacement surgery
This trial is testing the antibiotic vancomycin to prevent infections after total knee replacement. It may help if you are having your first knee replacement and are not severely overweight or diabetic.
San Diego, CaliforniaAges 18 years+ - NCT04336579Recruiting
Breathing exercises during knee replacement care
This study tests whether practicing diaphragmatic (belly/chest-breathing) exercises during total knee replacement with a nerve pain catheter is helpful for comfort or recovery. You may qualify if you are having knee replacement and have the specific type of nerve catheter, and you’re willing to learn and follow the breathing routine.
Los Angeles, CaliforniaAges 50–90 - NCT07015905RecruitingPhase 3
Study of REGN7508 vs. standard blood thinners after knee replacement
This trial compares a new blood thinner called REGN7508 to two standard blood thinners (apixaban and enoxaparin) to prevent blood clots after total knee replacement surgery. The goal is to see which is safer and more effective.
Riverside, CaliforniaAges 18 years+ - NCT06784882RecruitingPhase 4
Continuous vs. single-injection nerve block for outpatient knee replacement
This trial compares two types of nerve blocks for pain control after total knee replacement. You will receive either a one-time injection or a continuous block that delivers medication through a small tube. The goal is to see which method provides better pain relief while allowing you to go home the same day.
La Jolla, CaliforniaAges 18 years+ - NCT03275610Enrolling by invitation
Genetic study in people with past lung blood clots after knee or hip surgery
This study looks at genetic (inherited DNA) markers in people who have had a lung blood clot (pulmonary embolism) after having a hip or knee replacement. The goal is to understand why blood clots may happen again and help improve future risk prediction and care.
Los Angeles, CaliforniaAges 18–70
Where these studies are running in California
Institutions with a site for the recruiting total knee arthroplasty studies listed above.
- University of Southern California · 2 studies
- 450 Broadway
- CARI Clinical Trials
- Cedars-Sinai Medical Center
- Eisenhower Medical Center
- Horizon Clinical Research
- Keck Medicine of USC
- University of California San Diego
What taking part in a total knee arthroplasty study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Total Knee Arthroplasty trials in other states
Common questions
- Are there total knee arthroplasty clinical trials in California?
- Yes. We're currently tracking 9 recruiting total knee arthroplasty studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a total knee arthroplasty study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a total knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New total knee arthroplasty studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.