Clinical trials
Total Knee Arthroplasty clinical trials
Below are recruiting total knee arthroplasty clinical trials, each written for real people, not researchers. We’re tracking 227 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06309433Recruiting
Bone density after different knee replacement designs
This study looks at how bone density around a new knee replacement changes over time, comparing two different types of knee implants. It may help your surgeon choose the best option for you.
Bologna, ItaliaAges 45 years+ - NCT07313449Recruiting
Knee replacement study: 1-year results for a specific prosthesis
This study looks at how well a certain type of cemented total knee replacement works after at least one year. It may help doctors understand long-term outcomes for this specific knee implant.
StrasbourgAges 18 years+ - NCT05216666Recruiting
Surgery type and leftover limping after hip replacement
This study looks at whether the kind of hip surgery approach affects how much limping remains after a total hip replacement. You may benefit by helping researchers find the approach that leads to better walking after surgery.
MölndalAges 40–80 - NCT05898581Recruiting
Compare two pain block methods for hip replacement surgery
This trial studies whether one type of numbing injection (a PENG block) works better than another method (local anesthetic injected into the surgical area) to control pain during and after total hip replacement. It may help choose the best pain plan for people having a specific surgical approach.
London, OntarioAges 19 years+ - NCT07506330Enrolling by invitation
Surgical environment and surgeon stress study
This study looks at how different surgical environments affect the stress levels of orthopaedic surgeons. It compares doing joint replacements the traditional way versus using a robot, to see which approach might be easier on the surgeon.
LondonAges 18–65 - NCT04210284Recruiting
Oral nutrition support before hip or knee replacement
This trial tests whether an oral nutrition plan given before elective hip or knee replacement can help people with low nutrition (“malnutrition”) do better after surgery. If you’re a candidate for surgery and meet lab signs of poor nutrition, you may be asked to take an oral supplement by mouth.
New York, New YorkAges 55 years+ - NCT04295486RecruitingPhase 2
Low-dose aspirin to prevent blood clots after hip or knee surgery
This Phase 2 study tests the best dose of low-dose aspirin to help prevent dangerous blood clots after total hip or knee replacement surgery. If you’re at lower clot risk and can safely take aspirin, it may help reduce clot risk while you recover.
Miami, FloridaAges 19 years+ - NCT06902285RecruitingPhase 4
Magnesium supplement for better sleep after joint replacement
This study tests whether taking magnesium L-threonate can improve sleep quality after total knee or hip replacement surgery. It may help you sleep better during recovery.
Miami, FloridaAges 18 years+ - NCT03275610Enrolling by invitation
Genetic study in people with past lung blood clots after knee or hip surgery
This study looks at genetic (inherited DNA) markers in people who have had a lung blood clot (pulmonary embolism) after having a hip or knee replacement. The goal is to understand why blood clots may happen again and help improve future risk prediction and care.
Los Angeles, CaliforniaAges 18–70 - NCT06469177Enrolling by invitation
Pain management app study for joint replacement recovery
This study tests a smartphone tool to help manage pain after hip, knee, or shoulder replacement. It aims to see if using the tool improves your recovery compared to standard care.
Dartmouth, Nova ScotiaAges 19 years+ - NCT06563531Recruiting
Do compression stockings help after hip or knee replacement?
This trial looks at whether compression stockings are still needed for people who have a new hip or knee joint and are following a modern "fast-track" recovery program. It aims to find out if these stockings are necessary to prevent blood clots when people are up and moving quickly after surgery.
BrestAges 18 years+
Hear when a new Total Knee Arthroplasty trial opens
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Common questions
- Are there clinical trials for total knee arthroplasty?
- Yes. Clin2 currently lists 227 recruiting total knee arthroplasty studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee arthroplasty trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee arthroplasty trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.