Clinical trials
Total Knee Replacement clinical trials
Below are recruiting total knee replacement clinical trials, each written for real people, not researchers. We’re tracking 116 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07356323Recruiting
Study on antibacterial drape for hip or knee replacement
This trial tests if a special antibacterial drape reduces contamination during hip or knee replacement surgery. The drape is placed over the skin to help prevent infection.
Fishers, IndianaAges 22 years+ - NCT06839807Recruiting
Testing a new device for knee replacement loosening
This study tests a new device (AtMoves Knee System) to help diagnose if a knee replacement is loose. It is for people who have had a knee replacement and have symptoms that might mean the implant is loose, but standard tests have not given a clear answer.
Nijmegen, GelderlandAges 18 years+ - NCT07584915Enrolling by invitationPhase 4
Pain Relief Method Comparison for Knee Replacement Surgery
This study tests a new way to deliver pain medication during and after knee replacement surgery. Researchers compare injecting a long-acting numbing medicine (EXPAREL) directly into the knee joint versus spreading it through the surgical area, to see which method works better for pain control.
Los Angeles, CaliforniaAges 18 years+ - NCT07275983Recruiting
Knee replacement recovery: spinal vs. general anesthesia
This study looks at recovery after total knee replacement surgery. It compares people who had spinal anesthesia (numbing the lower body) to those who had general anesthesia (being fully asleep) to see which group recovers better.
StrasbourgAges 18 years+ - NCT07319546Recruiting
Faster recovery after first knee replacement
This study tests a faster, more active recovery program for people having their first total knee replacement. It may help you get back to daily activities sooner after surgery.
Dali, YunnanAges 50–80 - NCT07003932Recruiting
Remote monitoring after knee replacement surgery
This trial tests a remote monitoring program for people having knee replacement surgery. It uses a smartphone app to track your recovery, so you can stay in touch with your care team without needing extra clinic visits.
Oslo, Please SelectAges 50 years+ - NCT07371390Recruiting
Minimal sedation for knee replacement surgery
This trial tests whether less sedation during knee replacement surgery can improve recovery. It may help you if you are having your first total knee replacement and can have spinal anesthesia.
Rochester, MinnesotaAges 18 years+ - NCT06596031Enrolling by invitation
Health coaching for people waiting for hip or knee replacement
This study tests whether health coaching can help people who are waiting for hip or knee replacement surgery. It aims to improve your health and wellbeing while you wait for your operation.
SheffieldAges 18 years+ - NCT03048201Recruiting
Total Knee Replacement Registry Study for a Specific Knee Implant
This study tracks outcomes for people getting a total knee replacement using a specific knee implant system. It may help doctors understand which patients do best and how the implant performs over time.
Rancho Mirage, CaliforniaAges 22 years+ - NCT04275362Recruiting
Walking analysis after a specific knee replacement design
This study looks at how people walk after receiving a particular total knee replacement design. It compares movement patterns (gait analysis) to help understand how well the knee works in real life.
Phoenix, ArizonaAges 50 years+ - NCT04732962Recruiting
Special shoes to help knee osteoarthritis symptoms without surgery
This study tests whether custom biomechanical footwear can reduce pain and improve function in people with knee osteoarthritis. It may help as a non-surgical option to ease symptoms while you’re considering or preparing for care.
Danville, PennsylvaniaAges 45–80 - NCT04858347Recruiting
Study of a specific knee implant and recovery outcomes
This trial looks at how well a particular knee replacement (a GEMINI SL fixed-bearing prosthesis) works and how people function after surgery. It may help doctors learn what to expect for recovery and long-term results with this implant.
Cali, Valle del Cauca DepartmentAges 18–80 - NCT05487053Recruiting
Nerve block type test after knee replacement
This study compares two pain-control methods for the leg after a total knee replacement: a single injection versus a continuous nerve-block catheter. It aims to see which option helps people recover and do rehab better.
MoscowAges 18 years+ - NCT05488093Recruiting
Testing knee movement in severe knee arthritis before replacement surgery
This study checks how well your knee moves and how that relates to pain and function in people with severe knee arthritis who are about to get total knee replacement. It may help doctors better plan and evaluate treatment before surgery.
MontpellierAges 60 years+ - NCT05842538Recruiting
Robotic surgery for total knee replacement in arthritis
This trial studies whether robotic-assisted surgery can improve or standardize outcomes for people getting a total knee replacement for severe arthritis. It may help by using a robot to assist during the knee operation, but you must meet specific knee and health criteria.
GothenburgAges 18–80 - NCT05966519Recruiting
Study testing flexible planning for knee replacement with ROSA
This study looks at how flexible pre-op planning can be when you get a total knee replacement using the ROSA system. It may help doctors fine-tune surgery planning while keeping outcomes safe and effective.
Fukuoka, FukuokaAges 20 years+ - NCT06122727Recruiting
Custom vs standard knee replacement for better fit
This trial compares custom-made knee replacements (built to fit your unique knee shape) with standard, off-the-shelf knee replacements. It aims to see if a custom implant leads to better function and satisfaction after surgery.
BolognaAges 40–70 - NCT06234631RecruitingPhase 2
CBD to reduce opioids after knee replacement
This study tests if a daily CBD capsule can help reduce the need for opioid pain pills after a first-time total knee replacement. It is for people with osteoarthritis who are having surgery and are willing to avoid cannabis for a short time before and after.
Ann Arbor, MichiganAges 18–80 - NCT06280352Recruiting
Robotic vs custom knee replacement trial
This study compares two modern ways of doing knee replacement: robot-assisted surgery versus a custom-made implant tailored to your knee shape. It aims to see which approach leads to better recovery and function for people with osteoarthritis.
Graz, StyriaAges 40–90 - NCT06290336Recruiting
Exercise and education before knee replacement surgery
This study tests if exercise therapy and patient education before total knee replacement can improve recovery. It may help people waiting for their first knee replacement due to osteoarthritis.
Linköping, Östergötland CountyAges 40–85 - NCT06507046Recruiting
Personalized total knee replacement study in Norway
This trial is studying a more personalized approach to total knee replacement surgery. It is for people with moderate to severe knee arthritis who are already scheduled for a knee replacement at Kristiansund Hospital in Norway.
Kristiansund, Møre and RomsdalAges 18–80 - NCT06514365Recruiting
Comparing nerve blocks for pain after knee replacement
This trial compares two different ways of numbing the leg to provide better pain relief after total knee replacement surgery. It tests whether adding a popliteal sciatic nerve block (behind the knee) to a saphenous block (inner thigh) works better than adding an IPACK block (back of the knee).
Badalona, BarcelonaAges 18 years+ - NCT06522087Recruiting
40 Hz brain stimulation to prevent confusion after hip or knee replacement
This trial tests if a non-invasive 40 Hz brain stimulation can prevent delirium (sudden confusion) in older adults after hip or knee replacement surgery. Delirium is common after surgery in elderly patients, and this treatment aims to lower that risk.
Zhengzhou, HenanAges 65–85 - NCT06581965RecruitingPhase 4
Personalized blood clot prevention for hip or knee replacement
This trial compares a personalized approach to preventing blood clots after hip or knee replacement surgery with the standard one-size-fits-all method. The goal is to see if tailoring prevention to each patient works better and is safer.
Apeldoorn, GelderlandAges 18 years+
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Common questions
- Are there clinical trials for total knee replacement?
- Yes. Clin2 currently lists 116 recruiting total knee replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.