Clinical trials
Total Knee Replacement clinical trials
Below are recruiting total knee replacement clinical trials, each written for real people, not researchers. We’re tracking 122 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06670651Enrolling by invitation
Study of a new total knee replacement system
This trial is testing a new knee replacement system called LinkSymphoKnee. It is for people needing a first-time total knee replacement to help reduce pain and improve function.
Birmingham, AlabamaAges 18–79 - NCT06643845Recruiting
Can medical treatments delay or avoid knee replacement?
This trial tests whether a combination of non-surgical treatments can help people with knee osteoarthritis avoid or delay total knee replacement surgery. It may be an option if you are considering knee replacement but want to explore medical alternatives first.
AmiensAges 18–90 - NCT06596031Enrolling by invitation
Health coaching for people waiting for hip or knee replacement
This study tests whether health coaching can help people who are waiting for hip or knee replacement surgery. It aims to improve your health and wellbeing while you wait for your operation.
SheffieldAges 18 years+ - NCT06581965RecruitingPhase 4
Personalized blood clot prevention for hip or knee replacement
This trial compares a personalized approach to preventing blood clots after hip or knee replacement surgery with the standard one-size-fits-all method. The goal is to see if tailoring prevention to each patient works better and is safer.
Apeldoorn, GelderlandAges 18 years+ - NCT06447922Enrolling by invitation
Metal Levels After Knee Replacement
This study measures metal levels in the blood after knee replacement surgery. It may help researchers understand how metal from the new joint affects the body.
Rochester, MinnesotaAges 18–100 - NCT06290336Recruiting
Exercise and education before knee replacement surgery
This study tests if exercise therapy and patient education before total knee replacement can improve recovery. It may help people waiting for their first knee replacement due to osteoarthritis.
Linköping, Östergötland CountyAges 40–85 - NCT06234631RecruitingPhase 2
CBD to reduce opioids after knee replacement
This study tests if a daily CBD capsule can help reduce the need for opioid pain pills after a first-time total knee replacement. It is for people with osteoarthritis who are having surgery and are willing to avoid cannabis for a short time before and after.
Ann Arbor, MichiganAges 18–80 - NCT06203756Enrolling by invitation
Robotic-Assisted Knee Replacement Outcomes Study
This study tests a robotic-assisted system for knee replacement surgery. It aims to see how well patients do with the robotic help.
Flagstaff, ArizonaAges Any age - NCT06122727Recruiting
Custom vs standard knee replacement for better fit
This trial compares custom-made knee replacements (built to fit your unique knee shape) with standard, off-the-shelf knee replacements. It aims to see if a custom implant leads to better function and satisfaction after surgery.
BolognaAges 40–70 - NCT05966519Recruiting
Study testing flexible planning for knee replacement with ROSA
This study looks at how flexible pre-op planning can be when you get a total knee replacement using the ROSA system. It may help doctors fine-tune surgery planning while keeping outcomes safe and effective.
Fukuoka, FukuokaAges 20 years+ - NCT05736549RecruitingPhase 2
Tested stronger pain-blocking shot for knee replacement surgery
This Phase 2 study compares two ways to reduce pain after total knee replacement (TKA): a steroid-enhanced nerve block versus a numbing shot called Exparel. It aims to see which option improves comfort and recovery after surgery done with spinal anesthesia.
New Haven, ConnecticutAges 18 years+ - NCT05642260Recruiting
Fall-prevention program after knee replacement for older women
This trial tests whether a structured fall-prevention program can reduce the number of falls in older women after total knee replacement surgery. It may help you stay safer as you recover and move around.
Kuwait CityAges 60 years+ - NCT05487053Recruiting
Nerve block type test after knee replacement
This study compares two pain-control methods for the leg after a total knee replacement: a single injection versus a continuous nerve-block catheter. It aims to see which option helps people recover and do rehab better.
MoscowAges 18 years+ - NCT05488093Recruiting
Testing knee movement in severe knee arthritis before replacement surgery
This study checks how well your knee moves and how that relates to pain and function in people with severe knee arthritis who are about to get total knee replacement. It may help doctors better plan and evaluate treatment before surgery.
MontpellierAges 60 years+ - NCT05279092RecruitingPhase 2
Testing two pain-control injections for knee replacement surgery
This Phase 2 study compares two ways of reducing nerve pain after knee replacement surgery (total knee arthroplasty). It looks at whether steroid-enhanced pain medicine works better than a different numbing injection to improve recovery and comfort.
New Haven, ConnecticutAges 18 years+ - NCT05290818Recruiting
Robotic vs standard knee replacement for inner-joint wear
This trial compares robotic-assisted knee replacement with the usual (non-robotic) approach for people with severe arthritis on the inner (medial) side of the knee. It aims to see which method works better for pain and function while matching the right knee anatomy for certain implant types.
Edinburgh, LothianAges 50–75 - NCT04432012RecruitingPhase 4
Compare steroid shots versus other delivery after knee replacement
This study compares different ways of giving steroid medicine after a total knee replacement to see which approach works best and is well-tolerated. You may qualify if you’re getting a first (not repeat) knee implant and can follow the study steps.
LuganoAges 50–85 - NCT07696650Recruiting
Choose to Move Replacement Ready study
This study looks at a program called Choose to Move Replacement Ready (CTM-RR) for older adults and the people who help them get active. It tests how well the program works for activity coaches, participants, and healthcare referral partners.
Vancouver, British ColumbiaAges 50 years+ - NCT07539467Enrolling by invitation
Nerve Block and Tourniquet for Knee Surgery Pain Relief
This trial tests whether a nerve block (numbing injection near the thigh) combined with a tourniquet (pressure cuff) after knee replacement surgery reduces pain better than standard care. If it works, it could help patients recover more comfortably with less need for strong pain medications.
AnkaraAges 40–85 - NCT06251869Recruiting
Electrocautery vs. Scalpel in Joint Replacement Surgery
This trial compares two surgical tools—electrocautery and a cold knife (scalpel)—to see which works better during joint replacement surgery. It aims to find the best way to make incisions, which could mean less bleeding and faster healing.
Cluj-Napoca, ClujAges 18–90 - NCT07110324Recruiting
Understanding long-term pain after hip or knee replacement
This study looks at people who still have moderate to severe pain months after a hip or knee replacement. The goal is to learn more about what causes this pain and how it feels, which could help improve future treatments.
Østerbro, København ØAges 18 years+ - NCT07069179Recruiting
Choose to Move replacement study for older adults
This study tests a program called Choose to Move Replacement Ready (CTM-RR) designed for older adults. It looks at how well activity coaches and healthcare referral partners can help people get active.
Vancouver, British ColumbiaAges 50 years+ - NCT06603103Recruiting
Comparing two knee implants in total knee replacement
This study compares two types of knee implants (SpheriKA and Origin) used in total knee replacement surgery with a specific alignment technique. The goal is to see which one may lead to better outcomes for patients needing a first knee replacement.
MérignacAges 18 years+ - NCT05120492Recruiting
Program for severe knee arthritis and extreme weight
This feasibility study tests a practical approach to help people with very severe knee arthritis and very high body weight. It aims to find an effective and safe way to manage both conditions together in real-world care.
Halifax, Nova ScotiaAges 18–65
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Common questions
- Are there clinical trials for total knee replacement?
- Yes. Clin2 currently lists 122 recruiting total knee replacement studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a total knee replacement trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a total knee replacement trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.