Clinical trials
Tuberous Sclerosis clinical trials
Below are recruiting tuberous sclerosis clinical trials, each written for real people, not researchers. We’re tracking 24 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06764602Recruiting
Kidney health in kids with tuberous sclerosis
This study looks back at medical records to see how many children with tuberous sclerosis complex (TSC) have kidney problems. It may help doctors understand how common kidney issues are in kids with TSC.
BolognaAges Up to 17 years - NCT00001975Recruiting
Skin Tumors and Tuberous Sclerosis Study
This study looks at skin growths that develop in people with tuberous sclerosis (a genetic condition affecting multiple organs). Researchers want to understand these skin changes better and may test new treatments to help manage them.
Bethesda, MarylandAges 18–90 - NCT05534672RecruitingPhase 3
Rapamycin for drug-resistant seizures in tuberous sclerosis
This trial tests whether rapamycin (compared with a placebo) can reduce seizures caused by tuberous sclerosis complex (TSC) that have not been controlled by usual medicines. If you qualify, you may be helping doctors find a safer and more effective option for seizure control.
LodzAges 3 months–50 years - NCT07403266RecruitingPhase 3
Full-spectrum cannabis oil for seizures in tuberous sclerosis
This trial tests a full-spectrum cannabis extract to see if it reduces seizures in people with tuberous sclerosis complex (TSC) whose seizures have not been controlled by other treatments. If it works, it could offer a new option for managing hard-to-treat epilepsy.
MadridAges 2–65 - NCT07287202RecruitingPhase 1/Phase 2
A study of SVG103 for people with certain brain conditions and seizures
This trial tests a drug called SVG103 (Paxalisib) in adults with brain conditions that cause hard-to-control seizures: Focal Cortical Dysplasia Type II, Tuberous Sclerosis Complex, or Hemimegalencephaly. The goal is to see if SVG103 is safe and helps reduce seizures.
Heidelberg, VictoriaAges 18–65 - NCT06160310Recruiting
TSC & LAM Pregnancy Registry Study
This study is a registry that gathers information from pregnant women with Tuberous Sclerosis Complex (TSC) or Lymphangioleiomyomatosis (LAM), as well as infants born to them. The goal is to better understand how these conditions affect pregnancy and the baby's health.
Cincinnati, OhioAges Any age - NCT05676099Recruiting
TSC or LAM blood and health information registry
This study sets up a database and collection of “biosamples” (like blood or other body samples) from people with tuberous sclerosis complex (TSC) or sporadic lymphangioleiomyomatosis (LAM). The goal is to better understand how these conditions change over time and support future research.
Birmingham, AlabamaAges Any age - NCT06105736Recruiting
Online behavior program for children with tuberous sclerosis
This study tests a program called 'Regulating Together' for children with tuberous sclerosis complex who have behavior challenges. The program is done online with your child and you, and may help improve self-control and reduce outbursts.
Carrboro, North CarolinaAges 8–17 - NCT06081348RecruitingPhase 2
Sertraline vs. placebo for anxiety in kids with developmental disorders
This trial compares sertraline (a common antidepressant) to a placebo (a pill with no medicine) to see which better reduces anxiety in children and teens who also have a neurodevelopmental disorder like autism, ADHD, or Tourette's. The goal is to help you and your child understand if this treatment might offer relief from anxiety.
Calgary, AlbertaAges 8–17 - NCT03050268Recruiting
Study of childhood cancer risk in families
This study looks at inherited (family) risk for childhood cancers, including families with early cancers or known cancer risk conditions. It may help researchers understand why some children get cancer and improve future risk detection and care.
Memphis, TennesseeAges Any age - NCT04463316Recruiting
Clinic study for people with rare genetic conditions
This study is for people who have a rare syndrome or rare congenital condition and are seen at a rare-disease clinic. It aims to better understand these conditions and how care works in a team setting, which may help guide future treatment decisions.
Rotterdam, South HollandAges 18 years+ - NCT05104983RecruitingPhase 2
Sirolimus to prevent first seizures in babies with TSC
This Phase 2 study tests whether sirolimus (a targeted medicine) can stop or slow the start of seizures in very young babies diagnosed with tuberous sclerosis complex (TSC). If seizures are prevented early, it may also help protect early brain development.
Birmingham, AlabamaAges 1 day–6 months - NCT06065852Recruiting
National registry for rare kidney diseases
This study creates a registry to collect health information from people with rare kidney diseases. It aims to improve understanding and future treatments by tracking patient experiences.
Bristol, South WestAges Any age - NCT06330350Recruiting
Talking about family planning for genetic skin conditions
This study interviews people with inherited skin conditions (genodermatoses) who want to have children, and the doctors who care for them. The goal is to learn how to better support family planning decisions, like counseling about genetics and pregnancy risks.
Maastricht, LimburgAges Any age - NCT06523582Recruiting
Genetic study of neuroendocrine tumors in Mexican patients
This study aims to find genetic causes of neuroendocrine tumors in Mexican patients. By understanding your DNA, researchers hope to improve diagnosis and treatment for people with these rare conditions.
Mexico City, Mexico CityAges 18 years+ - NCT07304856Recruiting
Studying lung involvement in women with LAM or TSC
This trial examines tiny particles called extracellular vesicles from your blood to see if they can help doctors understand lung problems in women with lymphangioleiomyomatosis (LAM) or tuberous sclerosis complex (TSC). It may help find new ways to track the disease without invasive tests.
Milan, MilanoAges 18–80 - NCT07369505RecruitingPhase 1
A study of Sapu003 for advanced tumors sensitive to mTOR
This trial tests a new drug, Sapu003, in people with certain advanced cancers that may respond to mTOR-targeted therapy. It is looking at two groups: postmenopausal women with a type of breast cancer (HR+/HER2-), and adults with kidney, liver, neuroendocrine, or TSC-related tumors. The goal is to see if Sapu003 is safe and effective.
AdelaideAges 18 years+ - NCT00001465Recruiting
Understanding how lymphangioleiomyomatosis affects the lungs
This research study examines how a rare lung disease called lymphangioleiomyomatosis (LAM) develops and progresses. Researchers will study patients with LAM and healthy volunteers to better understand the disease and potentially improve treatment options.
Bethesda, MarylandAges 16–100 - NCT00001532Recruiting
How Genes Affect Lung Disease Development
This research study examines how genetic factors contribute to various lung diseases, including alpha-1 antitrypsin deficiency, cystic fibrosis, and chronic obstructive pulmonary disease. Researchers want to understand why some people develop lung disease and how genetics plays a role, which may help improve treatment in the future.
Bethesda, MarylandAges 2–90 - NCT07561957Recruiting
Smartphone app to help manage chronic kidney disease
This study tests a smartphone app designed to help people with chronic kidney disease (CKD)—a condition where the kidneys don't filter blood as well as they should—follow the latest medical guidelines. The app aims to make it easier for younger adults to stay on top of their kidney health and treatment.
DublinAges 16–30 - NCT07575347Recruiting
Gum Disease and Rare Kidney Disorders Study
This study explores whether people with certain rare kidney diseases or chronic kidney problems have more gum disease than others. Researchers will examine your teeth and gums to understand the connection and help improve care for people with kidney conditions.
BucharestAges 18 years+ - NCT06879665Enrolling by invitation
Tandem trial for caregivers of TSC patients
This trial aims to improve access to interventions for Tuberous Sclerosis Complex (TSC)-related issues by working with adult caregivers. If you are an adult caring for someone with TSC, this study may help close the gap to better support and treatments.
Silver Spring, MarylandAges 18 years+ - NCT06330324Enrolling by invitation
Reproductive choices for genetic skin conditions
This study looks at the choices families have when they carry a genetic skin condition. It aims to learn more about how prenatal testing and IVF with genetic testing can help.
Maastricht, LimburgAges Any age - NCT03836300Enrolling by invitation
Parent-infant coaching for families with young diagnoses
This study tests a parent-and-infant coaching program for babies and caregivers. It aims to see whether the program helps after an early diagnosis when English is used at home.
Research Triangle Park, North CarolinaAges Up to 99 years
Hear when a new Tuberous Sclerosis trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.
Tuberous Sclerosis trials by city
Studies with a site in or near these metro areas.
Tuberous Sclerosis trials by state
Studies with a site anywhere in these states.
Common questions
- Are there clinical trials for tuberous sclerosis?
- Yes. Clin2 currently lists 24 recruiting tuberous sclerosis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a tuberous sclerosis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a tuberous sclerosis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.