Clinical trials · California
Type 2 diabetes clinical trials in California
We’re tracking 105 recruiting type 2 diabetes studies with a site in California — including Phase 1/Phase 2, Phase 2 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in California
- NCT07260110Recruiting
Study of teplizumab vs. no treatment in stage 2 type 1 diabetes
This study watches people with stage 2 type 1 diabetes who either get teplizumab or not, to compare their real-world experiences. It helps researchers learn how the drug affects daily life.
San Francisco, CaliforniaAges 8 years+ - NCT07296484RecruitingPhase 2
Clofutriben for hard-to-control type 2 diabetes
This trial tests a new medication, clofutriben, for people with hard-to-control type 2 diabetes who might also have mild excess of a stress hormone called cortisol. It aims to see if the drug can help lower blood sugar and improve diabetes management.
Northridge, CaliforniaAges 18 years+ - NCT07355270Recruiting
Radiofrequency vapor ablation for type 2 diabetes
This trial tests a new device that uses radiofrequency energy to treat the lining of the upper small intestine in people with type 2 diabetes. The goal is to see if this treatment is safe and helps improve blood sugar control.
Newport Beach, CaliforniaAges 22–65 - NCT07386340Recruiting
Testing a new continuous glucose monitor with flash readings
This study tests a new sensor system that tracks glucose levels continuously and can give a quick reading when you wave a device over it. It aims to see if it's safe and accurate for people with diabetes.
Escondido, CaliforniaAges 18 years+ - NCT07415954RecruitingPhase 2
Testing a new diabetes medicine for blood sugar control
This study tests a new medicine, NNC0662-0419, in people with type 2 diabetes. You must be willing to lose a lot of weight (more than a quarter of your current weight) as part of the study to see if the medicine helps lower blood sugar.
Lancaster, CaliforniaAges 18–75 - NCT07502508RecruitingPhase 2
Icovamenib for type 2 diabetes with Ozempic
This trial tests an investigational pill called icovamenib for people with type 2 diabetes who are already on Ozempic but still have high blood sugar. The goal is to see if adding icovamenib helps lower blood sugar more safely.
Montclair, CaliforniaAges 18–70 - NCT07518004Recruiting
ROME GS System Study for diabetes glucose monitoring
This study tests the ROME GS System, a glucose monitoring device that measures blood sugar levels. The system includes a sensor placed under the skin and a transmitter worn on the body. If you have diabetes and want to help evaluate a new way to track your blood sugar, this trial may be for you.
Walnut Creek, CaliforniaAges 18 years+ - NCT07533175RecruitingPhase 3
Testing a new weight-loss medicine for type 2 diabetes
This study tests whether a new medicine called NNC0487-0111 helps people with type 2 diabetes and excess weight lose weight. You'll take the medicine along with your current diabetes care to see if it works better than standard treatment.
Escondido, CaliforniaAges 18 years+ - NCT07546929RecruitingPhase 2
HP-211 Safety Study for Type 2 Diabetes Treatment
This study tests a new medicine called HP-211 in people with early-stage type 2 diabetes to see if it's safe and helps control blood sugar. You'd take the study drug along with your current diabetes management.
Canoga Park, CaliforniaAges 18 years+ - NCT07564414RecruitingPhase 3
Weight Loss Study Comparing Two Doses of CagriSema
This study tests whether a new combination medication called CagriSema (in two different doses) helps people with obesity lose weight. You may qualify if you're 18 or older, have a BMI of 35 or higher, and either don't have type 2 diabetes or have it well-controlled.
Escondido, CaliforniaAges 18 years+ - NCT07598773Enrolling by invitation
Continuous glucose monitoring study for prediabetes and type 2 diabetes
This study asks you to wear a glucose monitor and smart ring for several months to help researchers understand how blood sugar changes throughout the day in people with prediabetes or type 2 diabetes. The goal is to learn how lifestyle and medications affect blood sugar control.
San Francisco, CaliforniaAges 18 years+ - NCT07019649Enrolling by invitation
AYUDA program for younger Latinx adults with type 2 diabetes
This study tests a program called AYUDA, which sends helpful text messages and support to younger Latinx adults (ages 18–44) who were recently diagnosed with type 2 diabetes and are raising children. The goal is to see if this program helps manage diabetes better.
Pleasanton, CaliforniaAges 18–44 - NCT06906653Enrolling by invitation
Proactive care for newly diagnosed type 2 diabetes
This trial tests a new, proactive approach to help people newly diagnosed with type 2 diabetes manage their condition through better initial care and support. If you’re a Kaiser Permanente Northern California member, you may get extra resources and guidance right from the start.
Pleasanton, CaliforniaAges 18–74 - NCT06002048Enrolling by invitation
AI Study for Diabetes Insights
This study uses artificial intelligence to better understand type 2 diabetes. It is open to adults with or without type 2 diabetes, and aims to improve care for everyone.
San Diego, CaliforniaAges 40–85 - NCT06296550Recruiting
Digital diabetes education with real-time CGM
This study tests whether a digital diabetes education program plus a continuous glucose monitor (CGM) helps people with type 2 diabetes manage their blood sugar better. You'll get the CGM and educational messages on your phone, and researchers will see if it improves your health.
San Diego, CaliforniaAges 18 years+ - NCT07061574RecruitingPhase 1/Phase 2
Study of immune-modulating drugs for new-onset type 1 diabetes
This study tests two different medications (Anti-Thymocyte Globulin and Adalimumab or Verapamil) to see if they can slow down the loss of insulin production in people with newly diagnosed type 1 diabetes. Participants will be randomly assigned to receive one of the treatments and will be followed for about a year to see how well their bodies still make insulin.
San Francisco, CaliforniaAges 9–20 - NCT05762107RecruitingPhase 2
Drug ZT-01 to reduce low blood sugar at night
This Phase 2 study tests ZT-01 to help prevent night-time low blood sugar (hypoglycemia) in people with type 1 diabetes. It may help if you’ve had low blood sugar during sleep or are at high risk based on recent glucose monitoring.
San Carlos, CaliforniaAges 18–75 - NCT07224321RecruitingPhase 2
Inhaled insulin for youth with newly diagnosed type 1 diabetes
This study tests an inhaled insulin called Afrezza for teenagers and children who have just been diagnosed with type 1 diabetes. It aims to see if this new way of taking insulin can help manage blood sugar and fit into their lives.
Los Angeles, CaliforniaAges 6–17 - NCT07088068RecruitingPhase 3
Teplizumab for newly diagnosed type 1 diabetes
This study tests whether teplizumab can help keep the body making insulin in people recently diagnosed with type 1 diabetes. It is for children and young adults aged 1 to 25, and compares the drug against a placebo.
Huntington Beach, CaliforniaAges 1–25 - NCT03746769RecruitingPhase 1/Phase 2
Testing gastrin to improve results of islet cell transplant
This trial looks at whether adding gastrin can improve outcomes after an islet cell transplant for people with type 1 diabetes. It may help some participants achieve better blood sugar control, but it also requires close follow-up and immune-suppressing medications to protect the new cells.
Duarte, CaliforniaAges 18–68 - NCT04428658Recruiting
Telehealth coaching for kids to improve blood sugar control
This trial tests whether extra diabetes coaching delivered through online video and online messages can lower blood sugar levels in children with type 1 diabetes. It may help your child improve diabetes control by combining real-time and non-real-time support.
Sacramento, CaliforniaAges 5–18 - NCT06524960RecruitingPhase 1/Phase 2
Denosumab for Preserving Insulin in Type 1 Diabetes
This study tests if denosumab, a drug normally used for bone health, can help preserve your body's own insulin production in type 1 diabetes. It might slow the loss of insulin-making cells, helping you maintain better blood sugar control over time.
Duarte, CaliforniaAges 18–50 - NCT06860516Recruiting
HLA Demographics Study in Adults With Type 1 Diabetes
This study (NCT06860516) is an observational trial of adults aged 18-55 with type 1 diabetes diagnosed within 6 months. It aims to collect demographic and HLA data.
San Francisco, CaliforniaAges 18–55 - NCT07187531RecruitingPhase 2
Testing a new drug to slow type 1 diabetes progression
This trial tests an experimental drug called SAB-142 to see if it can slow down or stop the progression of type 1 diabetes. It is designed for people who were recently diagnosed and still produce some insulin on their own.
San Francisco, CaliforniaAges 5–40
Type 2 diabetes trials by city in California
Where these studies are running in California
Institutions with a site for the recruiting type 2 diabetes studies listed above.
- Headlands Research - AMCR Institute · 5 studies
- Diablo Clinical Research · 4 studies
- University of California, San Francisco · 4 studies
- Ark Clinical Research · 3 studies
- City of Hope Comprehensive Cancer Center · 2 studies
- Kaiser Permanente Northern California · 2 studies
- Pacific Clinical Studies · 2 studies
- Torrance Clinical Research Institute, Inc. · 2 studies
What taking part in a type 2 diabetes study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Type 2 diabetes trials in other states
Common questions
- Are there type 2 diabetes clinical trials in California?
- Yes. We're currently tracking 105 recruiting type 2 diabetes studies with a site in California, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a type 2 diabetes study in California?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in California to take part?
- Not necessarily. These studies have a site in California, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a type 2 diabetes trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New type 2 diabetes studies open in California regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.