Clinical trials · Massachusetts
Type 2 diabetes clinical trials in Massachusetts
We’re tracking 45 recruiting type 2 diabetes studies with a site in Massachusetts — including Phase 1/Phase 2, Phase 2, Phase 3 and Phase 4 studies, each written for real people, not researchers.
Recruiting studies in Massachusetts
- NCT06783309RecruitingPhase 1/Phase 2
Testing CNP-103 for newly diagnosed type 1 diabetes
This trial tests a new study drug called CNP-103 for people ages 12-35 who were recently diagnosed (within 6 months) with stage 3 type 1 diabetes. The goal is to see if the drug can help preserve the body's ability to make some insulin, potentially slowing the need for more insulin shots.
Boston, MassachusettsAges 12–35 - NCT07064473RecruitingPhase 3
Testing vicadrostat plus empagliflozin for diabetes, high blood pressure, and heart disease
This study tests a new pill called vicadrostat taken with another medicine (empagliflozin) to see if it helps people with type 2 diabetes, high blood pressure, and heart disease. It may reduce the risk of heart problems, but you must not have had heart failure or use certain other heart medications.
Malden, MassachusettsAges 18 years+ - NCT07340320RecruitingPhase 2
CX11 tablets for type 2 diabetes
This trial tests an experimental drug called CX11 to see if it helps control blood sugar in people with type 2 diabetes who are already taking metformin. It may be an option for you if your blood sugar is not well controlled and you meet the health requirements.
Springfield, MassachusettsAges 18–75 - NCT07448974RecruitingPhase 3
Vitamin D for Preventing Type 2 Diabetes
This study tests if taking extra vitamin D can help people with prediabetes keep their blood sugar in a healthy range and lower the chance of developing type 2 diabetes. Participants will take high-dose or standard vitamin D and be monitored for about 2 years.
Boston, MassachusettsAges 30–74 - NCT07197788Enrolling by invitation
Continued access to the Endogenex device study for type 2 diabetes
This trial offers continued access to the Endogenex system for people who were in the sham (placebo) group of the ReCET study and have completed their 12-month visit. It tests a device that treats the duodenum to improve blood sugar control.
Quincy, MassachusettsAges 22 years+ - NCT05390892RecruitingPhase 4
Preventing kidney and heart damage in type 2 diabetes
This study tests whether diabetes medicines can help prevent worsening heart and kidney problems in people with type 2 diabetes. You’ll be assigned by chance to one of these medicine types, and your other care will be adjusted for safety.
Worcester, MassachusettsAges 40–80 - NCT07662109RecruitingPhase 3
Testing a new combo pill for type 2 diabetes
This study tests if a new medicine (elecoglipron) combined with dapagliflozin is safe and works better for adults with type 2 diabetes that isn't well controlled by diet or other medications.
Boston, MassachusettsAges 18 years+ - NCT07662135RecruitingPhase 3
A study of elecoglipron for type 2 diabetes with kidney problems
This trial tests a new medicine called elecoglipron to see if it helps control blood sugar in people with type 2 diabetes who also have reduced kidney function. You would continue taking your current SGLT2i medication (like dapagliflozin).
Braintree, MassachusettsAges 18 years+ - NCT07579702Recruiting
Omnipod 6 Versus Omnipod 5 Insulin Pump System
This study compares two versions of the Omnipod insulin pump system to see if the newer Omnipod 6 works better at managing blood sugar than the current Omnipod 5. You'll wear one of these systems for several months and share data about how well it helps control your diabetes.
Boston, MassachusettsAges 14–75 - NCT07521475Recruiting
Fully Closed Loop Insulin Pump for Type 2 Diabetes
This study tests a new automated insulin pump system (Omnipod) that adjusts insulin doses on its own throughout the day for people with type 2 diabetes. The goal is to see if it helps keep blood sugar levels more stable while reducing the burden of manual insulin management.
Boston, MassachusettsAges 18–75 - NCT05420051Recruiting
Program to boost happiness and emotional well-being in type 2 diabetes
This trial tests whether a support program using messages and coaching can improve emotional well-being and happiness for people with type 2 diabetes. It may also encourage healthier activity, especially if you’re currently not very active.
Boston, MassachusettsAges 18 years+ - NCT06138821Recruiting
Endoscopic sleeve gastroplasty for obesity and MASH
This study tests if a procedure called endoscopic sleeve gastroplasty helps people with obesity and a liver condition called MASH lose weight and improve their liver health. It might be an option if you have both obesity and MASH and haven't had weight-loss surgery before.
Boston, MassachusettsAges 18 years+ - NCT06236607Recruiting
Artificial pancreas trial for adults with type 1 diabetes
This trial tests a hybrid closed-loop system that automatically adjusts insulin delivery. It may help you manage your blood sugar more easily if you currently give yourself daily insulin shots.
Boston, MassachusettsAges 18–75 - NCT06251323Recruiting
Better diabetes care with team support and technology
This study tests a new way to help adults with type 2 diabetes get better care. It includes a team of healthcare providers and uses technology to support your treatment.
Boston, MassachusettsAges 18 years+ - NCT06525259Recruiting
Study on risk factors for type 2 diabetes in youth
This study looks for children and teens who are at high risk of developing type 2 diabetes to understand what factors lead to it. If your child is overweight, has slightly high blood sugar, and is in early to mid-puberty, they may be able to join.
Boston, MassachusettsAges 8–15 - NCT07011147Recruiting
Real-world test of automated insulin delivery in primary care
This study tests if an automated insulin delivery system (the iLet bionic pancreas) works well in real-world primary care settings for people with type 1 or type 2 diabetes. It aims to see if this technology can help manage blood sugar more easily.
Boston, MassachusettsAges 18–89 - NCT07271043Recruiting
High-protein drink for weight loss in type 2 diabetes
This study tests if a high-protein diabetes shake can help people with type 2 diabetes who are starting a new class of diabetes medications (GLP-1 or GIP receptor agonists) lose weight and improve body composition. Participants will either take the shake or a placebo drink for several weeks.
Boston, MassachusettsAges 18–75 - NCT07296484RecruitingPhase 2
Clofutriben for hard-to-control type 2 diabetes
This trial tests a new medication, clofutriben, for people with hard-to-control type 2 diabetes who might also have mild excess of a stress hormone called cortisol. It aims to see if the drug can help lower blood sugar and improve diabetes management.
Springfield, MassachusettsAges 18 years+ - NCT07197775Enrolling by invitation
Endogenex PULSE Registry: Tracking long-term outcomes
This registry collects information from people with type 2 diabetes who have already been treated with the Endogenex System. It helps researchers learn how the treatment works over time.
Quincy, MassachusettsAges 18 years+ - NCT07415954RecruitingPhase 2
Testing a new diabetes medicine for blood sugar control
This study tests a new medicine, NNC0662-0419, in people with type 2 diabetes. You must be willing to lose a lot of weight (more than a quarter of your current weight) as part of the study to see if the medicine helps lower blood sugar.
Boston, MassachusettsAges 18–75 - NCT07468188Recruiting
Diabetes Body Project: Body image support for women with type 2 diabetes
This study tests a program to help women with type 2 diabetes feel better about their body image. You'll attend group sessions that focus on improving how you see and feel about your body.
Boston, MassachusettsAges 18–40 - NCT06869057Recruiting
Improving diabetes care after hospital discharge
This study tests a redesigned discharge process to help people with type 2 diabetes manage their health after leaving the hospital. It focuses on patients who also have unmet social needs, like food or housing issues.
Worcester, MassachusettsAges 18 years+ - NCT05911256Enrolling by invitation
Community health coach plus pharmacist to improve diabetes sugars
This study tests whether a team of community health worker and pharmacist can help improve blood sugar control in people with type 2 diabetes. You may be asked to use a continuous glucose monitor (a sensor that tracks sugar levels) and take part in support visits.
Worcester, MassachusettsAges 25–75 - NCT07224321RecruitingPhase 2
Inhaled insulin for youth with newly diagnosed type 1 diabetes
This study tests an inhaled insulin called Afrezza for teenagers and children who have just been diagnosed with type 1 diabetes. It aims to see if this new way of taking insulin can help manage blood sugar and fit into their lives.
Boston, MassachusettsAges 6–17
Type 2 diabetes trials by city in Massachusetts
Where these studies are running in Massachusetts
Institutions with a site for the recruiting type 2 diabetes studies listed above.
- Joslin Diabetes Center · 6 studies
- Brigham and Women's Hospital · 3 studies
- Care Access · 2 studies
- Elixia Health · 2 studies
- Massachusetts General Hospital · 2 studies
- Research Site · 2 studies
- University of Massachusetts Chan Medical School · 2 studies
- ActivMed Practices and Research
What taking part in a type 2 diabetes study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Type 2 diabetes trials in other states
Common questions
- Are there type 2 diabetes clinical trials in Massachusetts?
- Yes. We're currently tracking 45 recruiting type 2 diabetes studies with a site in Massachusetts, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a type 2 diabetes study in Massachusetts?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Massachusetts to take part?
- Not necessarily. These studies have a site in Massachusetts, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a type 2 diabetes trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New type 2 diabetes studies open in Massachusetts regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.