Clinical trials
Ulcerative Colitis clinical trials
Below are recruiting ulcerative colitis clinical trials, each written for real people, not researchers. We’re tracking 293 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03804931RecruitingPhase 2/Phase 3
Stool transplant for moderate to severe ulcerative colitis
This trial tests whether transplanting stool bacteria into the colon (fecal microbiota transplantation) can improve ulcerative colitis symptoms in people with active, moderate to severe disease. If you qualify, the study team will also check that it’s safe for you and that you can safely undergo a scope exam.
Guangzhou, GuangdongAges 18–65 - NCT04121806Recruiting
Diet plan for active ulcerative colitis flare-ups
This trial studies whether a specific diet can improve symptoms and reduce inflammation during an active flare of ulcerative colitis. You may be eligible if you have documented active disease and can follow the study diet and medication rules.
Toronto, OntarioAges 18–75 - NCT04314375RecruitingPhase 4
Budesonide tablets for children with mild to moderate ulcerative colitis
This trial studies whether budesonide extended-release tablets are safe and effective for improving symptoms in children ages 5–17 with active, mild to moderate ulcerative colitis. It also measures how the medicine moves through the body.
Garden Grove, CaliforniaAges 5–17 - NCT04743518RecruitingPhase 4
How ulcerative colitis medicines affect blood vessel stiffness
This study looks at how common ulcerative colitis treatments (anti-TNF medicines, vedolizumab, or tofacitinib) change the health of your blood vessels. It may help doctors better understand cardiovascular risk in people with ulcerative colitis.
AmiensAges 18 years+ - NCT04844606RecruitingPhase 3
Mirikizumab for kids with ulcerative colitis or Crohn’s
This study checks whether continuing mirikizumab (a medicine that calms gut inflammation) helps children with ulcerative colitis or Crohn’s disease after prior study treatment. It aims to see if staying on the medicine is beneficial and safe over time.
San Francisco, CaliforniaAges 2–19 - NCT04999228RecruitingPhase 4
Top-down versus step-up treatment for pediatric ulcerative colitis
This trial compares two treatment approaches for children newly diagnosed with ulcerative colitis: starting with stronger medicines right away versus beginning simpler and stepping up if needed. It may help your child learn which strategy controls symptoms better with fewer flare-ups.
Shanghai, Shanghai MunicipalityAges 6–18 - NCT05076175RecruitingPhase 2/Phase 3
Oral ozanimod for children with moderate to severe ulcerative colitis
This trial tests whether an oral medicine called ozanimod can improve ulcerative colitis (UC) in children whose disease is moderate to severe. It’s meant for kids who didn’t fully respond—or couldn’t tolerate—standard UC treatments.
Phoenix, ArizonaAges 2–17 - NCT05218850RecruitingPhase 2
Butyrate treatment for kids with mild-to-moderate ulcerative colitis
This trial tests whether butyrate can help children and teens with mild-to-moderate ulcerative colitis (a long-term bowel inflammation condition). You may be able to join if your symptoms fit the study level and you haven’t recently started other specific ulcerative colitis treatments right before the study begins.
Los Angeles, CaliforniaAges 7–21 - NCT05327790RecruitingPhase 2
Fecal transplant to boost new biologic treatment for ulcerative colitis
This trial tests whether fecal microbiota transfer (a stool-based therapy) can improve outcomes when added to starting a new biologic medicine for ulcerative colitis. It compares fecal transplant versus placebo (a sham treatment) to see if symptoms and inflammation improve faster or more strongly.
Edmonton, AlbertaAges 18–75 - NCT05456412Recruiting
JAK medicine for active ulcerative colitis
This study tests whether a JAK-inhibitor medicine can improve symptoms in people with active ulcerative colitis. If you’re currently flaring, it may help calm inflammation and reduce symptoms.
Leiden, South HollandAges 16–65 - NCT05481619RecruitingPhase 4
Vedolizumab study for ulcerative colitis and gut changes
This trial tests whether vedolizumab helps people with moderate-to-severe ulcerative colitis and what changes happen in the gut microbiome (the community of helpful bacteria in your intestines). You may be able to join if you’re an adult with ulcerative colitis who has not used vedolizumab before and haven’t taken certain gut-affecting medicines recently.
Zhengzhou, HangzhouAges 18 years+ - NCT05610956RecruitingEarly Phase 1
Empagliflozin for mild-to-moderate ulcerative colitis
This early trial studies whether empagliflozin can improve ulcerative colitis symptoms and is safe for people with mild to moderate disease. If it works, it may reduce ongoing colon inflammation and help people feel better.
TantaAges 18–70 - NCT05628701Recruiting
Testing two UC surgery reconstructions after colectomy
This trial compares two ways of reconnecting the bowel after subtotal colectomy and ileostomy in people with ulcerative colitis (UC). It may help determine which surgical option works best when the rectum is calm enough to manage with topical mesalazine alone.
GothenburgAges 18–60 - NCT05666960RecruitingPhase 1
Study drug R-3750 for mild to moderate ulcerative colitis
This Phase 1 study tests whether R-3750 is safe in people with mild to moderate ulcerative colitis and looks for early signs it could help. You may be able to join if you have stable treatment, confirmed diagnosis, and meet several health and medication timing rules.
Valencia, CaliforniaAges 18–65 - NCT05791487Recruiting
Diet plus oral budesonide for mild to moderate ulcerative colitis
This trial studies whether combining a specific diet with an oral steroid called budesonide can calm symptoms in people with mild to moderate ulcerative colitis. It may help reduce inflammation in the colon while building on stable current treatments.
AfulaAges 17–65 - NCT05895981Recruiting
Sacral nerve stimulation for ulcerative colitis symptoms
This trial tests whether sacral nerve stimulation—a device that sends small electrical signals near nerves in the lower back—can be safe and helpful for ulcerative colitis. It is meant for people whose ulcerative colitis has not improved enough with medicines.
Xi'an, ShaanxiAges 18 years+ - NCT06029972RecruitingPhase 2
Experimental drug for moderate to severe ulcerative colitis
This trial tests an experimental medication (tilpisertib fosmecarbil) for people with moderate to severe ulcerative colitis who have already tried at least one advanced therapy but it didn't work well enough. The study aims to see if this new drug can help reduce inflammation and improve symptoms.
Sun City, ArizonaAges 18–75 - NCT06067698Recruiting
Alpha lipoic acid for mild to moderate ulcerative colitis
This trial tests whether adding alpha lipoic acid (an antioxidant) to your usual mesalamine treatment helps control mild to moderate ulcerative colitis. It is for people newly diagnosed and not on other UC treatments.
TantaAges 18 years+ - NCT06095596Recruiting
Combining vedolizumab and upadacitinib for ulcerative colitis
This trial tests whether two medications, vedolizumab (a biologic given by IV) and upadacitinib (a pill), work together to help people with moderate to severe ulcerative colitis. The goal is to see if this combination is safe and effective for controlling symptoms and healing the colon.
Guangzhou, GuangdongAges 18 years+ - NCT06213857RecruitingPhase 2
Silymarin for ulcerative colitis
This study tests whether silymarin (an extract from milk thistle) can help treat ulcerative colitis when added to your usual treatment. It may reduce inflammation and oxidative stress in the colon.
AsyutAges 18–65 - NCT06228352Recruiting
Bile acids and gut bacteria in C. difficile with ulcerative colitis
This study looks at how bile acids and gut bacteria relate to C. difficile infection in children with ulcerative colitis. It aims to find better ways to predict and treat these infections.
ParisAges Up to 17 years - NCT06231264Recruiting
Electrical acupressure for mild to moderate colitis
This trial tests whether a gentle electrical stimulation device (like acupuncture without needles) on the skin can help people with mild to moderate ulcerative colitis who haven't gotten better with standard treatments.
Xi'an, ShaanxiAges 18 years+ - NCT06294925Recruiting
Effectiveness of etrasimod in ulcerative colitis
This study looks at how well the daily pill etrasimod works for people with moderate to severe ulcerative colitis. It's for patients whose doctor has already decided to prescribe etrasimod as part of their routine care.
Kelowna, British ColumbiaAges 18–64 - NCT06311123Recruiting
Study of Ozanimod's Effects on Immune Cells in Ulcerative Colitis
This study looks at how the medicine ozanimod works in people with active ulcerative colitis. Researchers will use a special blood test to understand how the drug affects your immune system.
San Diego, CaliforniaAges 18 years+
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Common questions
- Are there clinical trials for ulcerative colitis?
- Yes. Clin2 currently lists 293 recruiting ulcerative colitis studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ulcerative colitis trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ulcerative colitis trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.