Treatment
Acetaminophen clinical trials
We’re tracking 65 recruiting studies that include Acetaminophen, each written for real people, not researchers, below.
Recruiting studies
- NCT06997016Enrolling by invitationPhase 4
Recovery program for living donor kidney transplant
This trial tests a special recovery program (ERAS) for people who get a kidney from a living donor. The program aims to help you heal faster and feel better after surgery.
Fort Worth, TexasAges 18 years+ - NCT06994442RecruitingPhase 3
Best pain relief for children on a breathing tube
This study tests adding extra pain medicines (acetaminophen or an NSAID) to usual opioid pain treatment for children on a breathing machine. The goal is to find the safest and most effective way to manage pain.
Little Rock, ArkansasAges 2 months–17 years - NCT06878014RecruitingPhase 4
Morphine for pain relief after hip replacement surgery
This trial tests different doses of morphine given during spinal anesthesia to find the safest and most effective way to control pain after hip replacement surgery. If you are having a total hip replacement, you may be able to join.
Sosnowiec, Silesian VoivodeshipAges 18–75 - NCT06863636RecruitingPhase 3
Combination painkiller vs celecoxib for osteoarthritis flare-ups
This study tests whether a combination of two pain relievers (celecoxib and acetaminophen) works better than celecoxib alone for sudden, severe osteoarthritis pain in the knee or hip.
Mexico CityAges 40 years+ - NCT06861920RecruitingPhase 4
NSAID use for painful periods to prevent chronic pelvic pain
This study tests whether using NSAIDs (like naproxen) for painful periods can help prevent chronic pelvic pain later on. It's for people with regular, painful periods who are otherwise healthy.
Evanston, IllinoisAges 18–35 - NCT06434233RecruitingPhase 4
Opioid use after fallopian tube removal surgery
This study looks at how much opioid pain medicine people need after having their fallopian tubes removed through small incisions (laparoscopic or robotic salpingectomy). It aims to see if the usual pain medicine can be reduced to decrease opioid use.
Baltimore, MarylandAges 18 years+ - NCT06824467RecruitingPhase 3
Maintenance Therapy Study for Recurrent Ovarian Cancer
This study tests a new maintenance treatment (sacituzumab tirumotecan) versus standard care for people with ovarian cancer that has come back after responding to platinum-based chemotherapy. The goal is to see if it can keep the cancer from growing longer and improve quality of life.
Birmingham, AlabamaAges 18 years+ - NCT06671002RecruitingPhase 4
Pain medicine safety study for kids having surgery
This study compares different pain medicines to see which works best and is safest for children after surgery for tonsil removal, gallbladder removal, or knee arthroscopy. It aims to help find the most effective and least risky pain control option.
Los Angeles, CaliforniaAges 12–20 - NCT04676802RecruitingPhase 2
Pain relief after thumb joint surgery: ibuprofen and acetaminophen versus oxycodone
This study compares two ways to manage pain after thumb joint removal surgery: one using over-the-counter pain relievers (ibuprofen and acetaminophen) and the other using a prescription opioid (oxycodone). The goal is to see if the non-opioid option works just as well with fewer side effects.
Redwood City, CaliforniaAges 45 years+ - NCT06379425RecruitingPhase 4
Can pain meds without opioids help you pee sooner after surgery?
This study looks at whether giving a mix of pain medicines (without opioids) before surgery can help you recover faster and avoid needing a catheter after a vaginal repair or sling procedure. It enrolls women having minor gynecologic surgery at the South Shore Surgery Center in New York.
Bay Shore, New YorkAges Any age - NCT06373978RecruitingPhase 4
Non-narcotic pain relief after elbow needle procedure
This study tests non-narcotic pain medicine after a needle procedure for chronic elbow tendon pain. It compares different pain-relief options to find what works best without opioids.
Coral Springs, FloridaAges 18–65 - NCT06356571RecruitingPhase 2
Isatuximab with carfilzomib and dexamethasone for multiple myeloma
This trial tests a new combination of drugs (isatuximab, carfilzomib, and dexamethasone) given as shots under the skin for people whose multiple myeloma has come back or stopped responding to treatment. It aims to see if this mix works better than previous options.
Phoenix, ArizonaAges 18 years+ - NCT06275191Enrolling by invitation
Testing non-opioid pain relief after tooth extraction
This trial tests whether alternative pain treatments can replace opioid painkillers after wisdom tooth or other tooth removal in teens and young adults. It aims to find safer ways to manage dental pain without relying on opioids.
Lexington, KentuckyAges 12–25 - NCT07632274RecruitingPhase 1
Testing a pain reliever liquid for children ages 6–11
This study tests a new liquid medicine that combines ibuprofen and acetaminophen (two common over-the-counter pain relievers) in children aged 6 to 11. Researchers want to see how well the medicine works and how safe it is for mild to moderate pain, such as headaches, toothaches, or pain after dental work or vaccines.
Salt Lake City, UtahAges 6–11 - NCT06043323RecruitingPhase 2
CAR T cells plus radiation for follicular lymphoma
This trial tests a combination of a CAR T-cell therapy (Axicabtagene Ciloleucel) with radiation therapy for people with follicular lymphoma that has come back or not responded to multiple treatments. The goal is to see if adding radiation can make the CAR T cells work better.
Houston, TexasAges 18 years+ - NCT05919745RecruitingPhase 4
Ibuprofen before mouth surgery to reduce pain sensing
This trial studies whether taking ibuprofen before tooth extraction and bone graft surgery can lower how much pain you feel afterward. It may help by changing the body’s pain response during healing.
Milwaukee, WisconsinAges 18 years+ - NCT05896228RecruitingPhase 2
Combination therapy for relapsed multiple myeloma to target MRD
This Phase 2 trial tests iberdomide plus daratumumab, carfilzomib, and dexamethasone in people whose multiple myeloma has come back or not responded. The goal is to increase how often patients reach “MRD-negative” status, meaning very small amounts of cancer cells are not detectable, which may help improve outcomes.
Miami, FloridaAges 18–75 - NCT05842044RecruitingPhase 2
NSAID pain medicine after robotic kidney-sparing surgery
This Phase 2 study looks at whether taking an anti-inflammatory pain medicine (an NSAID) after robotic partial nephrectomy is safe and helpful. It may reduce pain while checking for stomach, bleeding, and heart-related side effects after kidney-sparing surgery.
Miami, FloridaAges 18–99 - NCT05722002RecruitingPhase 4
Compare pain-med plans after low-risk surgery
This study tests which pain-medication plan works best and has the fewest side effects after certain low-risk surgeries. You may be assigned to receive opioid-based, NSAID-based, or acetaminophen-based pain control depending on your situation.
Ann Arbor, MichiganAges 18 years+ - NCT05674643Recruiting
Gastric testing during children’s surgery
This trial studies how the stomach is working in children around the time of surgery. It may help improve how doctors assess and manage stomach function to make surgery safer and more comfortable.
Boston, MassachusettsAges 2–18 - NCT05557448RecruitingPhase 2
N-Acetylcysteine treatment for serious acetaminophen overdose
This Phase 2 trial studies whether TYNADOTE® can treat people who have taken a harmful acetaminophen (Tylenol) overdose while checking safety. It may be considered if your overdose is high enough to put you at risk for liver injury and you can follow the treatment and follow-up visits.
Taipei, Beitou DistrictAges 20 years+ - NCT05319730RecruitingPhase 1/Phase 2
Testing new drugs, with or without pembrolizumab, for advanced esophageal cancer
This trial studies investigational cancer medicines, either alone or along with pembrolizumab, for people with advanced esophageal squamous cell cancer whose cancer has grown despite prior immune and platinum-based treatment. It may offer a new option after standard therapy has not worked.
Tucson, ArizonaAges 18 years+ - NCT04964310Recruiting
Testing genetic risk for acetaminophen-related liver injury
This study looks at whether certain genes can predict who is more likely to get liver injury after taking acetaminophen (also found in some cold/flu medicines). By comparing people who were affected with people who were not, it may help doctors identify higher-risk patients in the future.
Nanjing, JiangsuAges 14 years+ - NCT04224558RecruitingPhase 1/Phase 2
Stem cell transplant for hard-to-control Crohn’s disease
This early-phase study tests whether a stem cell transplant can improve Crohn’s disease in teens and young adults whose disease is active and not responding to standard medicines. It may help some people who are not doing well despite several prior treatments, but it also involves intensive study procedures and safety checks.
Los Angeles, CaliforniaAges 13–28
Common questions
- Are there clinical trials studying Acetaminophen?
- Yes. Clin2 currently lists 65 recruiting studies that include Acetaminophen, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Acetaminophen trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Acetaminophen an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Acetaminophen or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.