Treatment
IV Ketamine clinical trials
We’re tracking 15 recruiting studies that include IV Ketamine, each written for real people, not researchers, below.
Recruiting studies
- NCT07520487Recruiting
Ketamine Plus Spinal Anesthesia for Older Adults Undergoing Leg Surgery
This study tests whether adding ketamine (a type of anesthetic medication) to spinal anesthesia—numbing medication injected near the spine—can make the numbness last longer for older adults having leg surgery. The goal is to see if this combination improves pain control after surgery.
Cairo, Giza GovernorateAges 65 years+ - NCT06488586Recruiting
Ketamine vs Esketamine for treatment-resistant depression
This trial compares two forms of ketamine—given by IV or as a nasal spray—in people with major depression that hasn't improved after trying at least two other antidepressants. The goal is to see which treatment works better.
Kingston, OntarioAges 18–75 - NCT07476482Enrolling by invitation
Shared decision-making during planned C-section under spinal anesthesia
This trial tests whether involving you in decisions during your planned C-section can improve your experience. You will be awake under spinal anesthesia and the study focuses on helping you feel more in control.
AlexandriaAges 18 years+ - NCT06272461Recruiting
Comparing lidocaine vs. ketamine for colorectal surgery pain
This trial compares two pain-relief medicines (lidocaine vs. ketamine) given through an IV during open colorectal surgery. It aims to find which one works better to reduce pain after surgery.
NabeulAges 18–90 - NCT05306899RecruitingPhase 3
IV ketamine for chronic daily headaches
This trial tests whether an IV dose of ketamine can reduce chronic daily headaches and is safe for people with this condition. It may help by lowering headache frequency and severity, but it also has several medicine and health-related safety checks.
Toronto, OntarioAges 18–75 - NCT06366334Recruiting
Ketamine for Teens with Suicidal Thoughts in the ER
This study tests whether a single dose of ketamine, given through an IV, can quickly reduce suicidal thoughts in teenagers who come to the emergency department. It aims to find a faster way to help teens in crisis.
Ottawa, OntarioAges 12–17 - NCT04195256RecruitingPhase 2/Phase 3
Nasal sedation medicine for kids needing a quick procedure
This trial tests whether a nose spray (dexmedetomidine plus ketamine) can safely and effectively sedate children during an ED procedure for certain arm injuries. It may help reduce distress and improve comfort compared with usual care.
Edmonton, AlbertaAges 2–17 - NCT05019885RecruitingPhase 2
IV ketamine for hard-to-treat epilepsy in adults
This Phase 2 study tests whether a low dose of IV ketamine can reduce seizures in adults with drug-resistant epilepsy. It may help people whose seizures continue despite trying at least two appropriate seizure medicines.
New York, New YorkAges 18 years+ - NCT06480500RecruitingPhase 2
Online therapy and IV ketamine for severe depression with suicide risk
This study tests whether adding an online therapy (i-CBT) to intravenous (IV) ketamine is better than IV ketamine alone for people with treatment-resistant depression who are also thinking about suicide. You'll receive either ketamine or a comparison drug (midazolam), plus the online therapy, in a hospital setting.
Toronto, OntarioAges 21–65 - NCT06725277Recruiting
Observing ketamine and Spravato for depression
This study follows people who are already taking or about to start IV ketamine or Spravato® for hard-to-treat depression. Researchers want to learn more about how these treatments work in real life.
Milford, ConnecticutAges Any age - NCT07706478Recruiting
Ketamine and Talk Therapy for Tough Depression
This trial tests whether a combination of ketamine (given through an IV) and talk therapy can help people with depression that hasn't responded to other treatments. If you have tried multiple antidepressants and therapy without success, this study may offer a new option.
Doorn, UtrechtAges 18–70 - NCT07443254RecruitingPhase 1/Phase 2
IR-led deep sedation study for image-guided procedures
This study tests if a radiologist can safely give deep sedation medicine (ketamine) for certain procedures instead of general anesthesia. It might help you avoid general anesthesia while still being comfortable.
Charleston, West VirginiaAges 18 years+ - NCT06722742RecruitingPhase 3
Preventing shivering after spinal anesthesia for cesarean
This trial tests whether two common medicines, tramadol and ketamine, given through an IV, can prevent shivering that sometimes happens after spinal anesthesia for cesarean section. You may be able to join if you are having a planned cesarean and are generally healthy.
Karachi, SindhAges 18–40 - NCT06733129RecruitingPhase 3
Which sleeping medicine is best for emergency intubation?
This trial compares different sleeping medicines (ketamine, propofol, and similar drugs) to see which is safest for people who need a breathing tube placed quickly in the operating room. It focuses on those at risk of stomach contents going into the lungs.
AngersAges 18–80 - NCT07557576Recruiting
Pain management approaches for children having cleft surgery
This study compares two types of anesthesia (with and without opioid painkillers) for children undergoing cleft lip or palate surgery. The goal is to see which approach better controls pain after surgery and reduces agitation as the child wakes up.
ZagrebAges 3 months–7 years
What IV Ketamine is being studied for
Conditions with recruiting IV Ketamine studies.
Common questions
- Are there clinical trials studying IV Ketamine?
- Yes. Clin2 currently lists 15 recruiting studies that include IV Ketamine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a IV Ketamine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is IV Ketamine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether IV Ketamine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.