Treatment
Nicotinamide clinical trials
We’re tracking 51 recruiting studies that include Nicotinamide, each written for real people, not researchers, below.
Recruiting studies
- NCT06882096RecruitingPhase 1
How the body processes NAD+ boosters in healthy adults
This study looks at how the body uses NAD+ precursors (nutrients that help cells produce energy) after taking them by mouth. Healthy volunteers will help researchers understand how these supplements are processed, which may guide future treatments for aging and disease.
Boston, MassachusettsAges 18 years+ - NCT07024966Recruiting
A study of supplements for oxidative stress in runners
This study tests whether a combination of three natural supplements (pterostilbene, silybin, and nicotinamide riboside) can reduce exercise-related oxidative stress in amateur runners. If it works, these supplements might help protect your body's cells during intense running.
Reus, TarragonaAges 18–50 - NCT07144527Recruiting
NMN supplement for exercise in healthy older adults
This trial tests whether a supplement called nicotinamide mononucleotide (NMN) can help healthy adults aged 60 to 80 improve their exercise tolerance. You'll take the supplement and do supervised cycling sessions to see if it boosts your stamina.
Beverly Hills, CaliforniaAges 60–80 - NCT07563322Recruiting
Nicotinamide Riboside for Combined Pulmonary Hypertension
This study tests whether nicotinamide riboside (a B-vitamin supplement) can help people with combined pulmonary hypertension—a condition where blood pressure in the lungs is too high. The researchers want to understand how this supplement affects the body's energy metabolism and whether it might reduce symptoms and improve heart function.
Nashville, TennesseeAges 18–85 - NCT07579429RecruitingPhase 2
Nicotinamide Riboside Supplement for MDS
This trial tests whether a supplement called nicotinamide riboside can help people with a blood disorder called MDS (myelodysplastic syndrome) or early warning signs of it. The supplement is meant to support your bone marrow's ability to make healthy blood cells.
Aurora, ColoradoAges 18 years+ - NCT07703137Enrolling by invitation
NAD Supplement for Parkinson's Disease Study
This study tests whether a supplement called NAD (a natural substance that helps cells produce energy) can improve symptoms in people with Parkinson's disease. You would take the supplement daily for several weeks, and researchers will check your movement, thinking, and overall well-being.
Oklahoma City, OklahomaAges 55–85 - NCT07073352Recruiting
Childhood stress and blood vessel aging in young adults
This study looks at how childhood stress might affect blood vessels and aging in young adults. It tests if a certain protein (SIRT1) is linked to early blood vessel aging.
Iowa City, IowaAges 18–30 - NCT04913805RecruitingPhase 2
Study for HFpEF using heart pressure and energy signals
This Phase 2 study tests how matching heart “filling pressure” and heart muscle “energy use” may improve understanding or treatment of HFpEF, a type of heart failure with preserved pumping strength. You may be asked to have heart scans/tests and follow a study plan if your symptoms and test results fit.
Philadelphia, PennsylvaniaAges 18 years+ - NCT05483465RecruitingPhase 4
NAD supplement trial for brain blood vessel health in aging
This trial studies whether taking an NAD supplement can support brain blood vessel health as people age. Participants will be tested for brain and health changes and may help researchers understand how to keep the brain’s blood vessels healthier over time.
Oklahoma City, OklahomaAges 60–85 - NCT06345443Enrolling by invitation
Nicotinamide riboside for blood vessel health
This trial tests a nutritional supplement (nicotinamide riboside) to see how it affects blood flow in healthy adults. It may help understand how to support vascular health as we age.
Rochester, MinnesotaAges 35–70 - NCT07585006RecruitingPhase 1
How nicotine affects the body: comparing e-cigarette liquids
This study compares different nicotine products to understand how they affect your body. Researchers will measure your heart rate, breathing, and blood samples during three short lab visits. The results may help scientists better understand nicotine's effects.
Columbus, OhioAges 21 years+ - NCT06907329Recruiting
NMN supplement trial for middle-aged adults with metabolic issues
This trial tests whether a sustained-release nicotinamide mononucleotide (NMN) supplement can improve immune aging and metabolism in people aged 50-70 who are overweight or have fatty liver, pre-diabetes, or mild type 2 diabetes.
ShanghaiAges 50–70 - NCT04113486Recruiting
NMAP protein in new kidney or liver tumors
This study looks at a protein called NMAP in people who have a new kidney or liver mass that will be surgically removed. It helps researchers understand how this protein relates to cancer and might lead to better tests or treatments in the future.
Shanghai, Shanghai MunicipalityAges 18 years+ - NCT05095571Recruiting
Extension study of vitamin supplements for ALS
This study looks at continuing a nicotinamide/pterostilbene supplement in people with ALS who already finished an earlier related NO-ALS study. It may help researchers learn whether the supplement can be continued safely and potentially benefit longer-term outcomes.
BergenAges 35 years+ - NCT05194397RecruitingPhase 2
Exercise plus NR supplement to boost fitness after stem-cell transplant
This trial tests whether a supervised exercise program, plus an NR supplement, can improve fitness in young people who have had an allogeneic (donor) stem-cell transplant for certain blood cancers or bone marrow conditions. It’s meant to help with energy and physical ability while monitoring safety.
Duarte, CaliforniaAges 10–30 - NCT05245903Recruiting
Test a supplement and track brain changes with wearable sensors
This study tests whether taking nicotinamide riboside (a form of niacin) affects early memory changes in people with mild cognitive impairment (MCI) or mild Alzheimer’s disease (AD). It also uses passive wearable or sensor data (“digital biomarkers”) to measure changes over time.
Belmont, MassachusettsAges 18–89 - NCT05405868RecruitingPhase 3
Nicotinamide for early to moderate open-angle glaucoma
This trial tests whether nicotinamide (a form of vitamin B3) can slow vision changes from open-angle glaucoma. It compares nicotinamide versus a placebo (inactive pill) in adults with early to moderate disease.
Belfast, Northern IrelandAges 18 years+ - NCT06162013RecruitingPhase 2
NAD supplement trial for atypical parkinsonism
This trial tests whether a supplement called nicotinamide riboside (NR) can help people with rare forms of parkinsonism (PSP, MSA, or CBS). It is a double-blind study, meaning neither you nor the doctors will know if you are getting the real supplement or a placebo.
Oslo, OsloAges 30–85 - NCT06488625RecruitingPhase 2/Phase 3
Nicotinamide for mild to moderate ulcerative colitis
This trial tests whether a special oral form of nicotinamide (a type of vitamin B3) can help control mild to moderate ulcerative colitis. The pill is designed to release the medication in the lower part of your gut, where UC often affects. Participation involves taking the study drug and having regular checkups to see how your symptoms and inflammation respond.
Kiel, Schleswig-HolsteinAges 18–80 - NCT06592859Recruiting
NMN supplement study for healthy middle-aged and older adults
This study tests if nicotinamide mononucleotide (NMN), a natural supplement, can help middle-aged and older adults stay healthy. It aims to see if NMN can slow aging-related changes in healthy people between 40-70 years old.
Quzhou, ZhejiangAges 39–70 - NCT06627868Recruiting
NAD+ metabolism in human brown fat
This study explores how the body's natural substance NAD+ works in brown fat, a type of fat that burns calories. It may help researchers understand metabolism and find new ways to treat obesity.
TurkuAges 30–65 - NCT06776510RecruitingPhase 1/Phase 2
NAD for immune thrombocytopenia study
This trial tests if a substance called NAD can help adults with immune thrombocytopenia (ITP) whose platelet levels stay low even after standard treatments. ITP is a condition where the immune system attacks platelets, causing easy bruising and bleeding. The study aims to see if NAD can safely raise platelet counts.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07013591RecruitingPhase 2
NMN supplement before heart bypass surgery
This trial tests whether a supplement called nicotinamide mononucleotide (NMN) can help people recover better after heart bypass surgery. NMN is related to vitamin B3 and may protect the kidneys and heart during surgery.
Boston, MassachusettsAges 18 years+ - NCT07344636Recruiting
NR supplements and zone 2 training for metabolism
This trial tests whether taking nicotinamide riboside (a vitamin-like supplement) helps your body burn fuel better during moderate exercise, known as zone 2 training. It may benefit healthy adults who want to improve their workout efficiency.
Hong Kong, Please SelectAges 18–80
Common questions
- Are there clinical trials studying Nicotinamide?
- Yes. Clin2 currently lists 51 recruiting studies that include Nicotinamide, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Nicotinamide trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Nicotinamide an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Nicotinamide or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.