Treatment
Nicotine clinical trials
We’re tracking 139 recruiting studies that include Nicotine, each written for real people, not researchers, below.
Recruiting studies
- NCT05932745Recruiting
Test of new e-cig ingredients in current adult users
This study tests how new e-cigarette ingredients affect adults who already use e-cigarettes. You may be asked to avoid tobacco and nicotine briefly before sessions so researchers can measure effects more clearly.
New Haven, ConnecticutAges 18 years+ - NCT05934409Recruiting
Measuring body-fat storage after bariatric surgery
This study looks at how body fat is stored and how that may relate to early improvements in diabetes and heart/liver health after bariatric surgery. It may help researchers understand why some people recover faster and which body changes matter.
Sherbrooke, QuebecAges 18–65 - NCT05852860Enrolling by invitation
Mentoring program for HIV clinicians on tobacco cessation
This study tests a mentoring program to help clinicians who care for HIV patients learn more about helping patients quit smoking. It aims to improve how doctors and nurses support tobacco cessation in HIV care.
Philadelphia, PennsylvaniaAges Any age - NCT05815199Recruiting
E-cigarettes to help smokers with serious mental illness cut down
This study tests whether e-cigarettes can help people who smoke a lot reduce cigarette use (without requiring them to quit completely). It is designed for adults with serious mental illness and focuses on harm reduction and follow-up over time.
New York, New YorkAges 21 years+ - NCT05790486Recruiting
Take a Break program for adult smokers in rural areas
This trial tests a text-based program to help adults who smoke but are not ready to quit yet. It may help you think about quitting when you’re ready, without pushing you to stop right away.
Winston-Salem, North CarolinaAges 18 years+ - NCT05746442Recruiting
Interactive quitting messages for Khmer-speaking people with HIV
This trial tests whether interactive, personalized messages can help people who smoke cigarettes quit. It is designed for Khmer-speaking adults living with HIV and aims to support a quit attempt within about two weeks.
Phnom PenhAges 18 years+ - NCT05766553Recruiting
Virtual reality mindfulness to reduce cigarette cravings
This trial tests whether guided mindfulness meditation in virtual reality can lower cigarette cravings and help people quit smoking. It may help by reducing urges to smoke during stressful moments.
IteuilAges 18–75 - NCT05723588RecruitingPhase 2
TMS brain stimulation to help veterans quit smoking with PTSD
This Phase 2 study tests whether targeted brain stimulation (TMS) can improve smoking quit outcomes in Veterans who also have PTSD. It also uses brain imaging (MRI) to understand what changes in the brain may help people quit.
Durham, North CarolinaAges 18–75 - NCT05722561RecruitingPhase 2
E-cigarettes to reduce smoking in opioid use disorder
This Phase 2 study tests whether e-cigarettes can help people who use opioids (and also smoke cigarettes) cut down on combustible cigarette smoking. It looks at whether switching to e-cigarettes for “harm reduction” is safe and helps you smoke fewer cigarettes without requiring you to quit completely.
New York, New YorkAges 21–75 - NCT05707871RecruitingEarly Phase 1
Testing how low-nicotine cigarettes affect heart measurements
This early study checks whether very low-nicotine cigarettes change heart-related measurements during a lab visit. It may help researchers understand how lowering nicotine could affect cardiovascular (heart and blood vessel) function.
Winston-Salem, North CarolinaAges 21 years+ - NCT05630781Recruiting
Orexin's role in the neurobiology of addiction
This study looks at how a brain chemical called orexin affects addiction. Researchers will give a medication that blocks orexin to see if it helps reduce cravings or use. It might help people who smoke or vape regularly.
Baltimore, MarylandAges 18–60 - NCT05628389Recruiting
Phone-based help to quit smoking or waterpipe
This study offers phone support to help people quit smoking cigarettes and/or waterpipe. It may help you build a quit plan and get regular encouragement and coaching from a distance.
BeirutAges 18 years+ - NCT05447325Recruiting
Brain scans to study vaping to smoking risk
This study uses brain imaging to better predict who might start smoking cigarettes and who might increase nicotine use among young adult e-cigarette (vaping) users. It may help researchers find early warning signals so support can be targeted sooner.
Athens, GeorgiaAges 18–29 - NCT05276050Recruiting
Brain-circuit treatment to help people with schizophrenia quit smoking
This study tests a circuitry-guided approach to help people with schizophrenia quit smoking. It may help reduce cravings and improve quitting, while also watching for safety issues.
Houston, TexasAges 22–65 - NCT05181891RecruitingPhase 2
Trial uses enhanced cues to reduce alcohol and smoking
This Phase 2 study tests a program designed to help people cut down or stop heavy alcohol use and daily smoking at the same time. It will check your alcohol level at the start and uses urine tests during a short induction phase to confirm recent alcohol and ongoing smoking.
Spokane, WashingtonAges 18 years+ - NCT03540758RecruitingPhase 2
Study of how brain sugar control channels affect blood sugar
This Phase 2 study tests how certain channels in the brain help control how your body makes and releases sugar (glucose). It may help explain blood sugar problems in people with type 2 diabetes and healthy volunteers.
The Bronx, New YorkAges 21–70 - NCT03506867Enrolling by invitation
Test program to help recent smokers in Ottawa or Toronto
This trial offers a health program for people age 16+ who smoked recently and live in Ottawa or Toronto. It aims to help with quitting and follow-up over one year, especially for people facing financial hardship or housing instability.
Ottawa, OntarioAges 16 years+ - NCT03294460RecruitingPhase 1
Genetic study of smoking and alcohol response in healthy adults
This Phase 1 study tests whether certain genes linked to nicotine receptors affect how people feel and respond to alcohol. It also compares alcohol responses in smokers versus non-smokers using brain imaging (MRI) and alcohol-earning/reward tasks, aiming to better understand why some people may crave alcohol more than others.
Bethesda, MarylandAges 21–60 - NCT01036581Recruiting
Brain MRI study to improve brain imaging for drug research
This study uses advanced MRI brain scans to better show how the brain responds to medicines (drug-related effects). You may also do extra safety screening and non-invasive brain stimulation for some parts of the research.
Baltimore, MarylandAges 18–80
Common questions
- Are there clinical trials studying Nicotine?
- Yes. Clin2 currently lists 139 recruiting studies that include Nicotine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Nicotine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Nicotine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Nicotine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.