Treatment
Nicotine clinical trials
We’re tracking 139 recruiting studies that include Nicotine, each written for real people, not researchers, below.
Recruiting studies
- NCT06909500Recruiting
Vaping cessation app for young adults
This trial tests a smartphone app called ACT on Vaping to help young adults quit vaping. It may help you if you are ready to stop using e-cigarettes and want support through a digital tool.
Seattle, WashingtonAges 18–30 - NCT06837220Recruiting
Smoking cessation program for people in community behavioral health
This study tests a smoking cessation program designed for people who receive care at community behavioral health centers in Chicago. If you're a daily smoker interested in quitting, you may be able to join and get support to help you stop.
Chicago, IllinoisAges 18–26 - NCT06787937Recruiting
Study on reducing nicotine in cigarettes
This study tests cigarettes that have less nicotine to see how people react to them. You may be able to join if you are a regular adult smoker interested in trying reduced-nicotine cigarettes.
Atlanta, GeorgiaAges 21 years+ - NCT05505188Recruiting
Predicting long-term pain after head and neck radiotherapy
This study looks for ways to predict and improve pain you may have months after radiotherapy for first head and neck cancer. It may help doctors better anticipate pain and support patients during recovery.
CaenAges 18 years+ - NCT06765291Recruiting
Help for teens to quit or reduce vaping
This program is for teens aged 14 to 19 who vape at least once a week and want to quit or cut back. It tests a behavioral support approach to help them stop using nicotine vapes.
Boston, MassachusettsAges 14–19 - NCT06695884Recruiting
Finding the best TMS pulse pattern to boost brain reward activity
This study tests different pulse patterns of transcranial magnetic stimulation (TMS), a noninvasive brain stimulation, to see which one best increases activity in brain reward circuits. It may help people who are dependent on nicotine.
Newark, New JerseyAges 18–55 - NCT06688539RecruitingPhase 4
Quitting e-cigarettes in adults who also use cannabis
This trial tests if varenicline, a stop-smoking medication, can help people ages 18 to 40 quit e-cigarettes while also using cannabis. It's designed for regular e-cigarette users who want to quit and who use cannabis at least 10 days per month.
Charleston, South CarolinaAges 18–40 - NCT05233228RecruitingPhase 2
Phone-based coaching to help you quit smoking in Laos
This study tests a mobile phone program that gives personalized help to support quitting smoking. If you’re eligible, it may help you plan a quit date and stick with quitting using the app.
ChampasakAges 18–65 - NCT06662305RecruitingPhase 2
KickNic! App to Help Teens Quit Vaping
This study tests a new smartphone app called KickNic! to help teens quit vaping. If you're a regular vaper aged 12-19 and want to stop, the app might give you the support you need.
New Haven, ConnecticutAges 12–19 - NCT06582888RecruitingEarly Phase 1
VR attention test for smoking cravings
This study tests whether a virtual reality (VR) program can measure how your brain pays attention to smoking cues. It also involves taking a medication called varenicline (Chantix) to see if it reduces cravings. You may be eligible if you are a daily smoker, have been smoking for at least 3 years, and are not ready to quit in the next month.
San Diego, CaliforniaAges 22 years+ - NCT06582706RecruitingPhase 1/Phase 2
Vitamin B3 (niacin) for Alzheimer's disease
This study tests if nicotinic acid (a form of vitamin B3) can help people with mild to moderate Alzheimer's disease. It involves taking a daily pill, having a lumbar puncture, and regular check-ups to see if the vitamin improves thinking and memory.
Indianapolis, IndianaAges 60–85 - NCT06556238Recruiting
Smoking cessation trial for Alaska Native people
This study tests a personalized approach to help Alaska Native and American Indian people quit smoking. You will get treatment based on a blood test, and the study will see if this approach works better than standard care.
Anchorage, AlaskaAges 18 years+ - NCT06474299RecruitingPhase 4
Quitting cigarettes and vaping with medication support
This study tests whether using two quit-smoking medicines together helps people stop both cigarettes and vaping. It may offer extra support to help you quit.
Madison, WisconsinAges 21 years+ - NCT06448351Recruiting
Changing nicotine in e-cigarettes to reduce harm
This study tests how changing the amount of nicotine in e-cigarettes affects people's behavior. It looks at two groups: young adults who already vape and older adult smokers who want to try vaping, to see if different nicotine levels can help reduce smoking or make vaping safer.
Columbus, OhioAges 21–65 - NCT06395415Recruiting
Mobile health program for young adult e-cigarette users
This study tests a mobile health program to help young adults ages 18–26 who use e-cigarettes regularly to reduce or quit. It uses text messages to support you, and you'll need to be interested in changing your vaping habits.
Chicago, IllinoisAges 18–26 - NCT06290869RecruitingPhase 3
Tobacco education and lung scan study
This study tests whether a special health education program, along with a free lung scan, can help long-term smokers quit. You may be able to join if you are a current smoker between 50 and 80 years old and have never had lung cancer.
Washington D.C., District of ColumbiaAges 50–80 - NCT06260683Recruiting
Comparing tobacco vs. non-tobacco flavored e-cigarettes for quitting smoking
This study tests whether using e-cigarettes with a tobacco flavor or a non-tobacco flavor helps people who smoke switch away from regular cigarettes. Participants will use either e-cigarettes or nicotine replacement therapy for a period of time, and researchers will track their smoking behavior.
Columbus, OhioAges 21 years+ - NCT06239350Recruiting
Young adult tobacco and cannabis co-use study
This study tests a program to help young adults who use both nicotine and cannabis products reduce or quit nicotine use. If you are between 18 and 25, use nicotine products at least 20 days a month and cannabis at least 10 days a month, and want to quit nicotine, you may be eligible.
Charleston, South CarolinaAges 18–25 - NCT06249984Recruiting
Comparing moist snuff products for adult users in rural areas
This study compares different types of moist snuff to understand how they affect users. It may help find ways to reduce harm for people who use smokeless tobacco.
Columbus, OhioAges 21 years+ - NCT06232447Recruiting
Menthol smoking and inflammation study
This study looks at how menthol cigarettes affect inflammation and smoking habits. It uses a smartphone app to track your experiences and may help find better ways to help people quit.
North Chicago, IllinoisAges 21–85 - NCT06192316Recruiting
Testing how nicotine product claims affect appeal and use
This study looks at how different claims about nicotine products affect people's interest and use. It involves both young adults who don't use tobacco and adult tobacco users, but all must not have used oral nicotine pouches recently.
Columbus, OhioAges 18–65 - NCT06127589Recruiting
Quit for Kids: help parents quit smoking and protect children
This study offers a program to help parents who smoke quit for good, while protecting their young children from secondhand smoke. It uses text messaging and support to make quitting easier.
Hong KongAges 18 years+ - NCT05766254Recruiting
Brain stimulation study for nicotine dependence and reward activity
This trial tests different targets for repetitive transcranial magnetic stimulation (rTMS)—a non-surgical brain stimulation—to change brain “reward” activity in people who are nicotine dependent. If you qualify, you may receive sessions of brain stimulation as the researchers look for the best brain target.
Newark, New JerseyAges 18–55 - NCT05999383RecruitingPhase 2
Marijuana and tobacco use study
This trial looks at how marijuana and tobacco work together in your body. If you regularly use both cannabis and tobacco, you may help researchers understand their combined effects.
San Francisco, CaliforniaAges 21–65
Common questions
- Are there clinical trials studying Nicotine?
- Yes. Clin2 currently lists 139 recruiting studies that include Nicotine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Nicotine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Nicotine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Nicotine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.