Treatment
Nicotine clinical trials
We’re tracking 146 recruiting studies that include Nicotine, each written for real people, not researchers, below.
Recruiting studies
- NCT07142668Recruiting
How cigarette cost and availability affect tobacco buying
This study looks at how changing cigarette prices and availability affects what and how much tobacco people buy. It may help inform future policies that aim to reduce smoking.
Buffalo, New YorkAges 21 years+ - NCT06077240Recruiting
E-cigarettes vs pouches for quitting smoking
This study compares the effects of e-cigarettes and nicotine pouches on smoking habits and addiction. The goal is to see which method helps people smoke less and reduces their dependence on cigarettes.
New Haven, ConnecticutAges 21 years+ - NCT07348224Recruiting
Nicotine and nicotine-like products study
This trial tests how your body processes synthetic nicotine and nicotine-like substances when used in e-cigarettes. The goal is to understand how they work and how long they stay in your system.
BernAges 18 years+ - NCT06832098RecruitingPhase 3
Nicotine patch plus spray vs reducing nicotine to quit vaping
This study tests two ways to help you stop vaping: using a nicotine patch and mouth spray, or slowly lowering the nicotine in your vape. If you live in New Zealand, vape regularly, and are ready to quit, this trial may help you find the best method.
AucklandAges 16 years+ - NCT05962229RecruitingPhase 1
Testing how synthetic nicotine is processed in regular e-cig users
This Phase 1 study tests how a synthetic nicotine product is absorbed and how the body responds (so researchers can better understand nicotine effects and handling). You may be able to join if you’re generally healthy and regularly use e-cigarettes, but you’ll need to avoid certain medicines and nicotine products during the study.
San Francisco, CaliforniaAges 21–65 - NCT06043362Recruiting
Nicotine pouches for daily smokers
This study tests if nicotine pouches can help daily smokers reduce how many cigarettes they smoke. You'll try nicotine pouches, and researchers will track your progress.
Hershey, PennsylvaniaAges 21–70 - NCT06678789Recruiting
Testing low vs high nicotine pouches for smokers
This study compares how low and high nicotine pouches affect adult smokers who want to try a tobacco-free option. You'll attend two visits in Charleston to check health markers.
Charleston, South CarolinaAges 21 years+ - NCT06763536Recruiting
Comparing nicotine pouches vs. nicotine patches or gum to help smokers in rural Appalachia quit
This study tests if oral nicotine pouches work better than nicotine patches or gum to help you smoke less. You’ll use one of these products for a while and check in with the study team. This is for adults who live in rural Appalachian counties and smoke at least 5 cigarettes a day.
Columbus, OhioAges 21 years+ - NCT06254001RecruitingPhase 4
Combined tobacco treatment for hospitalized smokers
This trial tests a combination of treatments to help hospitalized smokers quit. If you are a smoker currently in the hospital, you may be able to join and get support to stop smoking.
Mexico CityAges 18 years+ - NCT07128329RecruitingPhase 1
Acute effects of oral nicotine pouches
This study tests how oral nicotine pouches affect the body, including heart rate and blood pressure, in both daily smokers and people who have used very little nicotine. It helps researchers understand the immediate effects of these pouches.
Baltimore, MarylandAges 21 years+ - NCT07466875Recruiting
Ear stimulation for nicotine withdrawal in psychiatric patients
This trial tests whether gentle electrical stimulation on the ear can help relieve nicotine withdrawal symptoms for smokers who are in a psychiatric hospital and must stop smoking. It is added on top of standard nicotine replacement therapy.
Nantou CityAges 18–65 - NCT06234722Enrolling by invitation
How Prices Affect Tobacco Use in Appalachia
This study looks at how the price of different tobacco and nicotine products might change how much people in Appalachia buy or use them. If you use nicotine or tobacco daily and don't plan to quit soon, you may be able to join.
Lexington, KentuckyAges 21 years+ - NCT06072547Recruiting
Can flavored nicotine pouches help you smoke less?
This study tests if flavored nicotine pouches can help adults who smoke at least 5 cigarettes a day switch away from smoking. You'll use the pouches instead of cigarettes, and researchers will track your smoking habits.
Raleigh, North CarolinaAges 22–65 - NCT05660525Recruiting
Helping rural smokers quit with pharmacist support and nicotine replacement
This study tests a smoking-cessation program delivered through community pharmacies in rural Appalachia. It may help people quit smoking using nicotine replacement (patch or lozenges) plus support from pharmacists.
Charlottesville, VirginiaAges 18 years+ - NCT05513872RecruitingPhase 1/Phase 2
Help to quit smoking using nicotine replacement while not quitting yet
This early-stage study tests ways to help adults who currently smoke daily start making progress toward quitting (or changing smoking habits) over the next 6 months. You may use nicotine replacement, and the study checks safety for people who can use it.
Chicago, IllinoisAges 18 years+ - NCT05515354RecruitingPhase 4
Smoking quit plan matched to your menstrual cycle phase
This Phase 4 study tests a smoking-quit treatment plan timed to your menstrual cycle. It may help you quit smoking and learn how quitting support works for people who menstruate regularly.
Toronto, OntarioAges 18–40 - NCT07165808Recruiting
Nicotine pouch abuse liability study
This study looks at how different nicotine pouch products affect people's desire to use them. It may help if you currently use nicotine pouches and are not planning to quit.
Atlanta, GeorgiaAges 21–35 - NCT07286747RecruitingPhase 2
Nicotinic Acid for Reversing Prediabetes
This trial tests whether a controlled-release form of nicotinic acid (a type of vitamin B3) can help people with prediabetes get their blood sugar back to normal. It also looks at how the treatment affects liver health.
KielAges 18–79 - NCT05154669RecruitingPhase 3
Coaching for quitting smoking and handling money worries
This Phase 3 study tests whether combining smoking-quit coaching with financial coaching helps people stop smoking and improve their finances. It may help if you smoke daily and also want support with money stress, while also checking that nicotine patch is safe for you.
New York, New YorkAges 18–100 - NCT07585006RecruitingPhase 1
How nicotine affects the body: comparing e-cigarette liquids
This study compares different nicotine products to understand how they affect your body. Researchers will measure your heart rate, breathing, and blood samples during three short lab visits. The results may help scientists better understand nicotine's effects.
Columbus, OhioAges 21 years+ - NCT06630728RecruitingPhase 4
How Addictive Are Very Low Nicotine Little Cigars?
This study is testing whether little cigars with very low nicotine are less addictive than regular ones. Researchers want to see how smoking these affects your mood, cravings, and smoking behavior.
Columbus, OhioAges 21–75 - NCT07625956Enrolling by invitationPhase 4
Nicotine Pouches as a Smoking Substitute Study
This study tests whether nicotine pouches (small pouches you place in your mouth) can help smokers quit or reduce combustible cigarettes. You'll use the pouches as a substitute and attend visits in Charleston, SC to see if this approach works better with new support strategies.
Charleston, South CarolinaAges 21 years+ - NCT06988371Enrolling by invitation
Study on smoking habits in a simulated tobacco marketplace
This study looks at how people who smoke occasionally or daily choose and use cigarettes in a simulated online marketplace. It may help researchers understand buying and smoking behaviors better.
Lexington, KentuckyAges 18 years+ - NCT04163081Recruiting
Help to quit smoking started from the emergency department
This study tests a program to help people who smoke quit, beginning when they are seen in the emergency department. It aims to see if starting nicotine-cessation support right away improves quitting over the next year.
Ottawa, OntarioAges 18 years+
What Nicotine is being studied for
Conditions with recruiting Nicotine studies.
Common questions
- Are there clinical trials studying Nicotine?
- Yes. Clin2 currently lists 146 recruiting studies that include Nicotine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Nicotine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Nicotine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Nicotine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.