Treatment
Opioid clinical trials
We’re tracking 430 recruiting studies that include Opioid, each written for real people, not researchers, below.
Recruiting studies
- NCT06416020Recruiting
Support for starting addiction treatment in community settings
This study looks at ways to help people who have just started taking buprenorphine for opioid use disorder stick with their treatment. It tests extra support outside of a clinic to help you stay on track and feel better.
Washington D.C., District of ColumbiaAges 16 years+ - NCT04979338RecruitingPhase 3
Opioid-sparing pain control for gender-affirming surgery
This Phase 3 study tests ways to manage pain during and after gender-affirming surgery while using less opioid medicine. It may help improve comfort after surgery and reduce opioid-related side effects.
Los Angeles, CaliforniaAges 18 years+ - NCT06379984RecruitingPhase 2
Quick-start buprenorphine for opioid addiction with fentanyl use
This trial tests a way to quickly start buprenorphine (a medication for opioid addiction) in an outpatient clinic for people who use fentanyl. It aims to make starting treatment easier and faster, without needing to go through full withdrawal first.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06379425RecruitingPhase 4
Can pain meds without opioids help you pee sooner after surgery?
This study looks at whether giving a mix of pain medicines (without opioids) before surgery can help you recover faster and avoid needing a catheter after a vaginal repair or sling procedure. It enrolls women having minor gynecologic surgery at the South Shore Surgery Center in New York.
Bay Shore, New YorkAges Any age - NCT06370481Recruiting
HIV and addiction training program for Alabama clinics
This study tests a program to help people living with HIV in Alabama who also struggle with opioid or stimulant use. It takes place at your HIV clinic and checks whether a new approach to addiction care can improve your health.
Birmingham, AlabamaAges 18 years+ - NCT06350786Recruiting
Using a placebo to help reduce opioid pain medication
This trial tests whether a special placebo pill, given with your knowledge, can help you reduce your opioid pain medication. You'll work with your own doctor to safely lower your dose while taking the placebo.
Zurich, Canton of ZurichAges 18 years+ - NCT06338280RecruitingPhase 2
Observing methadone treatment remotely
This study tests if using a smartphone app to watch you take your methadone works as well as going to a clinic every day. It might make treatment easier for you.
Chicago, IllinoisAges 18–64 - NCT06320015Recruiting
Peer support for recovery after an emergency visit
This trial tests whether a peer recovery worker can help adults who came to the emergency room for a drug- or alcohol-related problem stay engaged in recovery. If you join, you'll get extra support from someone who has been through similar experiences.
Providence, Rhode IslandAges 18 years+ - NCT06323837RecruitingPhase 2
Testing mirtazapine for methamphetamine use in people on opioid treatment
This trial tests whether the antidepressant mirtazapine can help reduce methamphetamine use in people who are already receiving medication for opioid use disorder. It aims to see if adding this medication improves outcomes for those struggling with both conditions.
Spokane, WashingtonAges 18 years+ - NCT06297200Recruiting
Ultrasound treatment for complex back pain patients
This study tests a new, non-invasive ultrasound treatment for people with long-term back pain who also have opioid use disorder and anxiety. It aims to see if this gentle brain stimulation can reduce pain and improve quality of life.
Roanoke, VirginiaAges 18–65 - NCT06306443RecruitingPhase 3
Buprenorphine treatment for people leaving jail
This trial offers buprenorphine (a medication for opioid use disorder) to people in jail who are soon to be released. It helps you start treatment while incarcerated and continue it after you return to the community, aiming to reduce overdose and improve recovery.
Baltimore, MarylandAges 18 years+ - NCT06288711Recruiting
Video therapy for PTSD in people taking opioid medication
This trial tests a therapy called prolonged exposure (a type of talk therapy) delivered via video calls to help people with both opioid use disorder and PTSD. It aims to see if this approach can reduce PTSD symptoms.
Burlington, VermontAges 18 years+ - NCT04512144Recruiting
Mindfulness coaching for endometrial or cervical cancer patients
This study tests a mindfulness program (using an app) for people newly diagnosed with endometrial cancer surgery or cervical cancer treated with chemo-sensitizing radiation. It may help improve how you cope during treatment.
St Louis, MissouriAges 18–90 - NCT06234631RecruitingPhase 2
CBD to reduce opioids after knee replacement
This study tests if a daily CBD capsule can help reduce the need for opioid pain pills after a first-time total knee replacement. It is for people with osteoarthritis who are having surgery and are willing to avoid cannabis for a short time before and after.
Ann Arbor, MichiganAges 18–80 - NCT06223503Recruiting
Pain support service study for veterans after surgery
This study tests a telehealth pain support program for veterans having orthopedic surgery. It aims to help manage pain after surgery and reduce the need for long-term opioid use.
Salt Lake City, UtahAges 18 years+ - NCT06015711Recruiting
Does a pre-surgery painkiller reduce strong IV pain meds needed?
This trial tests if taking Maxigesic® (a combination of two pain relievers) before surgery can lower the amount of a strong IV pain medicine called remifentanil needed during anesthesia. It may help patients have a smoother recovery with fewer side effects.
Suwon, Gyeonggi-doAges 19–60 - NCT06157840Recruiting
Sleep program for people on buprenorphine treatment
This trial tests a mobile health sleep program for people who are on buprenorphine for opioid use disorder and have trouble sleeping. It aims to help improve sleep and support your recovery journey.
Charleston, South CarolinaAges 18 years+ - NCT05642026RecruitingPhase 4
Continuous nerve block for pain from multiple broken ribs
This study tests a continuous nerve block—a numbing medicine delivered near the nerves—to reduce pain from rib fractures. It may help people with two or more broken ribs manage pain more effectively while recovering.
Lexington, KentuckyAges 18 years+ - NCT06136247Recruiting
Brain & thinking tests in opioid use disorder
This study tests whether brain scans and thinking tests can help understand opioid use disorder. It is for people on stable buprenorphine or methadone treatment.
Philadelphia, PennsylvaniaAges 18–60 - NCT06113211RecruitingPhase 4
Non-opioid pain control after fracture surgery
This trial tests a combination of non-opioid medications to manage pain after surgery for a broken bone, aiming to reduce or avoid the use of opioids. It may help you control pain without the risks of strong painkillers.
Detroit, MichiganAges 18–80 - NCT06103370Recruiting
HIV prevention via telemedicine and peer networks
This study tests how well a program combining telemedicine (virtual doctor visits) and peer support can help prevent HIV among people who inject drugs. You'd get trained, attend weekly group sessions, and invite a friend or partner to also take part.
Baltimore, MarylandAges 18 years+ - NCT06100172Recruiting
Ear Stimulation After Back Surgery
This study tests whether a gentle electrical stimulation placed on the ear (tAuricular Neurostimulation) can help reduce pain and improve recovery after lumbar spine surgery. It is for people who are already scheduled for a lumbar fusion or laminectomy and want to see if this non-invasive approach can ease their post-surgery discomfort.
Dallas, TexasAges 18–85 - NCT06084221Enrolling by invitation
Studying overdose review teams to improve surveillance
This study looks at how local overdose fatality review (OFR) teams work and how they can help track and prevent overdoses better. Researchers will also use anonymous administrative data to understand overdose patterns in Indiana. The goal is to make our surveillance systems stronger and save lives.
Indianapolis, IndianaAges Any age - NCT04724252RecruitingPhase 2/Phase 3
Gabapentin to help children use less opioid after surgery
This study tests whether gabapentin can reduce how much opioid pain medicine children need after certain major chest or heart surgeries. If it works, it may lower opioid-related side effects while still helping with postoperative pain.
Sacramento, CaliforniaAges Up to 17 years
Common questions
- Are there clinical trials studying Opioid?
- Yes. Clin2 currently lists 430 recruiting studies that include Opioid, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Opioid trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Opioid an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Opioid or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.