Treatment
Psilocybin clinical trials
We’re tracking 104 recruiting studies that include Psilocybin, each written for real people, not researchers, below.
Recruiting studies
- NCT07610369RecruitingPhase 2
Psilocybin therapy for depression in Parkinson's disease
This study tests whether psilocybin (a psychedelic compound) combined with therapy can reduce depression in people with Parkinson's disease. If you have moderate-to-severe depression and Parkinson's, this trial may offer a new treatment option.
New Haven, ConnecticutAges 40–80 - NCT07610135RecruitingPhase 1/Phase 2
Psilocybin with or without pimavanserin pretreatment
This trial tests whether taking pimavanserin before psilocybin changes the drug's effects in healthy volunteers who have never used psychedelics. It aims to understand how to make psychedelic therapy safer and more predictable.
Baltimore, MarylandAges 21–65 - NCT07607938RecruitingPhase 1
Psilocybin for Depression With Loss of Interest or Pleasure
This study tests whether psilocybin, a naturally occurring psychedelic compound, can help people with depression who experience anhedonia—a loss of interest or pleasure in activities. Researchers will monitor your brain activity and mood changes over time to see if this treatment is safe and helpful.
New York, New YorkAges 18–65 - NCT07565493RecruitingEarly Phase 1
Psilocybin with a serotonin blocker in healthy adults
This early-stage research study tests how psilocybin (a naturally occurring compound from certain mushrooms) works when combined with a medication that blocks a specific serotonin pathway in the brain. Researchers want to understand how these two substances interact in healthy volunteers to inform future psychiatric treatment studies.
Baltimore, MarylandAges 21–60 - NCT07516405RecruitingPhase 1
Psilocybin Safety Study in Older Adults
This research tests whether psilocybin (a psychoactive compound from certain mushrooms) is safe and well-tolerated in healthy people aged 65–85. Researchers want to understand how older adults respond to this substance and whether it could be useful for future treatments.
San Francisco, CaliforniaAges 65–85 - NCT07506395RecruitingPhase 1
Psilocybin group therapy for PTSD
This study tests if psilocybin-assisted group therapy can help people with moderate to severe PTSD. It is for veterans, first responders, female survivors of sexual violence, or Indigenous individuals.
Albuquerque, New MexicoAges 18–89 - NCT07490353RecruitingPhase 1
Can psilocybin help treat loss of pleasure?
This trial tests if psilocybin, a psychedelic substance, can improve the ability to feel pleasure (anhedonia) in people with depression who are not taking antidepressants. It also includes healthy volunteers as a comparison group.
Vienna, State of ViennaAges 18–55 - NCT07332143RecruitingPhase 2
Psilocybin-assisted therapy for PTSD in military members
This study tests whether a drug called psilocybin (the active ingredient in 'magic mushrooms') combined with therapy can help treat PTSD in military personnel and veterans. You'll receive the drug during a supervised session, along with talk therapy, to see if it reduces PTSD symptoms.
Atlanta, GeorgiaAges 18 years+ - NCT07281352RecruitingPhase 1/Phase 2
Psilocybin therapy for depression
This study tests if psilocybin (a psychedelic) combined with cognitive behavioral therapy (CBT) can help people with major depression. You would receive the psilocybin in a supervised setting and have talk therapy before and after.
Los Angeles, CaliforniaAges 21–60 - NCT06899334RecruitingPhase 1
Comparing LSD, psilocybin, and DMT in healthy volunteers
This study compares how three different psychedelic substances affect your state of mind. The goal is to better understand these altered states, which may help develop future treatments.
BaselAges 25 years+ - NCT07251491RecruitingPhase 1/Phase 2
Psilocybin for depression after spinal cord injury
This trial tests whether psilocybin (a substance found in certain mushrooms) can help treat depression in people with a spinal cord injury. You would receive the study drug in a controlled setting, and your progress would be monitored closely.
The Bronx, New YorkAges 22 years+ - NCT06731335RecruitingPhase 2
Psilocybin for chronic nerve pain that hasn't improved with other treatments
This study tests whether psilocybin (a compound found in certain mushrooms) can help reduce chronic nerve pain that has not responded well to standard medications. You will receive study treatment plus psychotherapy to see if it improves your pain.
Toronto, OntarioAges 18–65 - NCT07226232RecruitingPhase 3
Psilocybin for veterans with treatment-resistant depression
This study tests whether psilocybin (a psychedelic substance) can help veterans with depression that hasn't improved with standard treatments.
Birmingham, AlabamaAges 18–75 - NCT07216404RecruitingPhase 2
Psilocybin therapy for depression in lung cancer patients
This trial tests whether a psychedelic-assisted therapy can help treat major depression in people with non-small cell lung cancer. If you have moderate to severe depression and are receiving cancer treatment, you may be able to join.
Columbus, OhioAges 18 years+ - NCT07183748RecruitingPhase 2
Psilocybin microdosing plus therapy for hard-to-treat depression
This trial tests whether taking very small, repeated doses of psilocybin (a substance found in magic mushrooms) along with talk therapy can help people with depression that hasn't gotten better with other treatments. You'll need to stop your current depression medications and avoid drugs or alcohol for the study period.
BeershebaAges 18–65 - NCT07169747RecruitingPhase 2
Psilocybin with therapy for young adults with anorexia
This study tests two different doses of psilocybin, a substance that may help change thinking patterns, given alongside psychological support to young adults with anorexia nervosa. It aims to see if it is safe and helpful for weight recovery and mental health.
LundAges 16–35 - NCT07118332RecruitingEarly Phase 1
Psilocybin for chronic pain in veterans who smoke
This trial tests if psilocybin can help veterans with chronic pain who also smoke cigarettes. You will take psilocybin in a controlled setting to see if it reduces pain and helps with smoking.
West Haven, ConnecticutAges 21–65 - NCT07079930RecruitingPhase 1
Study on psilocybin and D-serine safety in healthy volunteers
This trial tests whether a combination of psilocybin and D-serine is safe and affects mood and thinking. It's for healthy people who want to help research on psychedelics.
JerusalemAges 25–60 - NCT07072728RecruitingPhase 2
Psilocybin therapy for anxiety in cancer patients
This trial tests whether psilocybin (a psychedelic drug given with talk therapy) can help people with cancer who have adjustment disorder—a condition where a cancer diagnosis causes severe anxiety or stress. It focuses on reducing anxiety and improving emotional well-being.
Abbotsford, VictoriaAges 18–80 - NCT07063862RecruitingPhase 3
Psychedelic microdose for emotional distress in advanced illness
This trial tests whether very low doses of psilocybin (a psychedelic substance) can help reduce emotional distress in people with a life-limiting illness. If you are receiving palliative care and feeling anxious or depressed, this study might offer a way to explore a new treatment option.
Brampton, OntarioAges 18 years+ - NCT07048743RecruitingPhase 2
Psilocybin therapy for caregivers of advanced cancer patients
This trial tests whether psilocybin-assisted therapy can help caregivers of people with advanced cancer who feel anxious or depressed. It focuses on improving emotional well-being and relationships.
Toronto, OntarioAges 18 years+ - NCT06989957RecruitingPhase 1
Psilocybin and MDMA therapy for PTSD in veterans
This study tests whether a combination of two investigational drugs, psilocybin and MDMA, can help veterans with post-traumatic stress disorder (PTSD). You would receive the drugs in a controlled setting and be monitored closely.
Baltimore, MarylandAges 21 years+ - NCT06988319RecruitingPhase 1
Psilocybin for chronic pelvic pain in women: a pilot study
This trial tests whether psilocybin (a psychedelic drug) can help women with long-term pelvic pain that hasn't gotten better with standard treatments. The goal is to see if it's possible and safe to use this approach in a future larger study.
Portland, OregonAges 18–45 - NCT06969170RecruitingPhase 2
Psilocybin oral solution for generalized anxiety disorder trial
This study tests a psilocybin oral solution in adults with generalized anxiety disorder (GAD). It aims to see if the drug is safe, tolerable, and helpful for reducing anxiety symptoms.
Kingston, OntarioAges 18–60
Common questions
- Are there clinical trials studying Psilocybin?
- Yes. Clin2 currently lists 104 recruiting studies that include Psilocybin, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Psilocybin trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Psilocybin an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Psilocybin or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.