Clin2
NCT03223220Possibly a fitNot yet recruiting

Ketamine for acute ischemic stroke

Acute Ischemic Stroke

Treatments studied

Part of Brain & nervous system, Heart & circulation clinical trials.

This trial tests whether a single dose of ketamine, given within 24 hours of a stroke, can reduce brain damage and improve recovery. It is designed for people who had a recent ischemic stroke and who are not eligible for standard clot-busting or clot-removal treatments.

Summary written for real people, not researchers, by Clin2.

Phase
Phase 2/Phase 3
Enrollment
120 people
Ages
18 years and older
Study type
Interventional

Who can take part

  • You must be 18 years or older.
  • You must have had an ischemic stroke (a blockage in a blood vessel in the brain) within the last 24 hours.
  • You must have had a stroke confirmed by an MRI scan.
  • Before the stroke, you must have been able to take care of yourself (modified Rankin score 0–2).
  • You must not be eligible for standard treatments like IV Alteplase (a clot-busting drug) or mechanical thrombectomy (clot removal).
  • You must be willing to provide written consent (or have a family member/caregiver do so).

View the official record on ClinicalTrials.gov

Quick eligibility check

Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.

Similar studies

Other trials that look related to this one.

NCT06994975Recruiting· Phase 3
Stroke drug test for patients who missed the 4.5 hour window

This trial tests a clot-busting drug for people who had a stroke more than 4.5 hours ago. It uses a special CT scan to see if the treatment can still help them.

Shanghai, Shanghai Municipality
NCT06137300Not yet recruiting
Study of a new drug for acute stroke from narrowed brain arteries

This trial tests whether a drug called urinary kallidinogenase can help people who have had a stroke caused by a blocked artery in the brain. The drug is given within 48 hours of the stroke, and the study hopes to see if it improves recovery and reduces disability.

Changchun, Jilin
NCT04916197Recruiting· Phase 4
Dexmedetomidine sedation after stroke clot removal

This Phase 4 study tests whether using a specific calming medicine (dexmedetomidine) for a longer period after a successful clot-removal procedure helps people do better in the long term. It may help improve outcomes after ischemic stroke where the clot is successfully treated.

Beijing, Beijing Municipality
NCT07475949Recruiting· Phase 3
Stroke treatment for unknown wake-up time

This trial tests a clot-busting drug for people who had a stroke but don't know when it started, like waking up with symptoms. It may help reduce disability if given soon after noticing symptoms.

Xiamen, Fujian
NCT06788249Recruiting· Early Phase 1
Ketamine for treatment-resistant depression brain study

This trial tests whether a single dose of ketamine can quickly improve depression by studying brain chemical changes using MRI. It's for people with treatment-resistant depression who haven't used ketamine before.

Philadelphia, Pennsylvania
NCT07177235Not yet recruiting· Phase 4
Ketamine for seizures that won't stop

This study tests whether ketamine can help stop seizures that haven't responded to standard treatments. It's for people with a serious condition called status epilepticus, where seizures don't stop on their own.

Philadelphia, Pennsylvania

Hear when a new Acute Ischemic Stroke trial opens

We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.