Whole-brain radiation with a targeted drug plan for brain mets
Treatments studied
Part of Brain & nervous system, Cancer clinical trials.
This Phase 2 study tests a treatment plan that combines whole-brain radiation therapy with an additional approach to help people with brain metastases. It aims to improve outcomes while also tracking brain function and memory over time.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 or older and have a solid cancer that has spread to the brain (brain metastases) needing whole-brain radiation
- You can have brain MRI scans with contrast dye (gadolinium)
- Your day-to-day function is good enough (Karnofsky score 70 or higher) and you should be expected to live more than 6 months
- You do not already have “leptomeningeal disease” (cancer affecting the membranes around the brain/spinal fluid)
- You have never had whole-brain radiation before and you are not taking memantine or other NMDA-blocking drugs
- You can understand English, complete questionnaires/testing, and come back for follow-up visits up to 2 years
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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