Radioimmunotherapy then CD19 CAR T for hard-to-treat blood cancers
Treatments studied
Part of Blood & lymphatic, Cancer, Digestive system, Immune system & allergy clinical trials.
This early-phase study tests a two-step treatment: first a targeted radioactive antibody (131-I apamistamab) and then CD19 CAR T-cell therapy. It is for adults with relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL) or diffuse large B-cell lymphoma (DLBCL) that is not responding or has come back, aiming to shrink cancer using engineered immune cells.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be age 18 or older
- Have B-ALL (or B lymphoblastic lymphoma) or DLBCL/high-grade B-cell lymphoma that has relapsed or is refractory (not improving within 6 months of last treatment)
- Have enough cancer evidence to test for both steps: at leukapheresis you must have CD19-positive cancer, and right before CAR T you must still have measurable “residual” cancer
- Have at least one measurable lesion on PET scan (FDG-avid) for DLBCL or B-ALL criteria (your team will confirm)
- Be well enough to tolerate treatment: ECOG performance status 0–2 and adequate blood counts, kidney, liver, and lung function
- Be able to have treatment safely: no pregnancy or breastfeeding, and you must use effective contraception during treatment and for 1 year after
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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