Ibuprofen plus acetaminophen for a heart condition in very premature babies
Treatments studied
Part of Genetic & congenital, Heart & circulation clinical trials.
This Phase 2 study tests whether giving ibuprofen together with acetaminophen improves outcomes for an important heart connection (PDA) in extremely premature infants. It compares how this medicine approach affects the baby’s heart-related measurements and short-term progress.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Your baby was born before 27 weeks of pregnancy
- The baby has a PDA seen on an ultrasound/echo, with mostly left-to-right blood flow
- Your care team plans to start the first course of ibuprofen by IV or by mouth
- Your baby’s kidneys are working well (urine output and blood tests are above set limits)
- Your baby’s liver blood tests are not too high
- The baby’s platelet count is high enough (not too low)
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies whether giving medicine soon can help preterm babies with a patent ductus arteriosus (a temporary leaking blood vessel in the heart). It aims to see if early treatment improves outcomes for very early gestational age infants.
This study tests a personalized way to give ibuprofen to very premature babies with a heart condition called PDA. It aims to see if adjusting the dose can help close the heart opening more safely.
This trial tests a personalized approach for treating a heart duct problem (PDA) in very premature babies (born before 32 weeks). It uses special markers and drug delivery systems to find the best treatment for each baby.
This trial measures a substance called prostaglandin E2 (PGE2) in preterm babies to see if it can predict whether a heart blood vessel (ductus arteriosus) will close on its own or need treatment. This could help doctors decide when to use medication to close the vessel.
This trial compares an early procedure to close a heart vessel called the ductus arteriosus versus careful observation alone in very low-birth-weight preterm infants. It aims to see whether closing the vessel early can improve outcomes and be done safely.
This trial tests whether giving an omega-3 fat medicine through an IV (along with standard care) improves breathing and blood-flow problems in newborns with congenital diaphragmatic hernia and persistent pulmonary hypertension. It may help reduce strain on the lungs and heart by targeting inflammation and blood-vessel changes.
Hear when a new Patent Ductus Arteriosus After Premature Birth trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.