Medication intensification after first treatment failure in mood and psychosis
Treatments studied
Part of Mental health clinical trials.
This Phase 3 study tests a stronger medication approach after your first current treatment hasn’t worked well enough. It targets people with schizophrenia, major depressive disorder, or bipolar depression who still have significant symptoms and life impact.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Be 18–70 years old for schizophrenia, up to 65 for major depression, and no upper age limit for bipolar depression
- Have a confirmed diagnosis of schizophrenia (or related conditions), major depression without hallucinations, or bipolar depression during a depressive episode
- Have a clear “treatment failure” right now (your current medicine didn’t control symptoms as expected, even after at least 4 weeks at a proper dose)
- Have moderate-or-worse symptoms and noticeable daily functioning problems
- If you can become pregnant, use effective birth control; if you use valproate during the study, use effective birth control measures
- Be willing to sign written consent before any study procedures
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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