Treatment
Clozapine clinical trials
We’re tracking 16 recruiting studies that include Clozapine, each written for real people, not researchers, below.
Recruiting studies
- NCT02639702RecruitingPhase 4
Switching from twice-daily to once-daily clozapine for schizophrenia
This trial tests whether taking clozapine once a day (instead of twice a day) works safely for people with schizophrenia. It may help by simplifying your dosing schedule while closely monitoring your wellbeing.
Toronto, OntarioAges 18 years+ - NCT04580134RecruitingPhase 4
Clozapine study for people with a specific schizophrenia or bipolar type
This trial tests whether clozapine works better for people whose illness fits a specific “biotype-1” pattern. It may help reduce ongoing symptoms, but it also requires close safety monitoring.
Hartford, ConnecticutAges 18–60 - NCT05208190RecruitingPhase 4
Clozapine to prevent violence in schizophrenia
This trial tests whether clozapine can reduce repeat violent behavior in people with schizophrenia or schizoaffective disorder. Participants are randomly assigned to clozapine or usual care to see which approach works better for preventing violence.
Los Angeles, CaliforniaAges 18–65 - NCT05316883RecruitingPhase 4
Testing blood markers in people on clozapine for schizophrenia
This study looks at “biomarkers,” or blood measures, in people with schizophrenia who respond to clozapine. It may help researchers understand who benefits from clozapine and why, by linking test results to symptom changes.
Glostrup Municipality, DenmarkAges 18–64 - NCT06505668Recruiting
Comparing two heart rate medicines for clozapine users
This study compares two medications (atenolol and ivabradine) to see which one better controls a fast heart rate (tachycardia) in people with treatment-resistant schizophrenia who are taking clozapine. The goal is to find a safer way to manage this side effect.
Bhubaneswar, OdishaAges 18–60 - NCT06573320Recruiting
Exercise for schizophrenia patients on clozapine
This trial tests whether a regular exercise program can help improve symptoms, thinking, and quality of life for people with schizophrenia who take a specific medication called clozapine.
IstanbulAges 18–65 - NCT06634641RecruitingPhase 4
Clozapine and immune function in Parkinson's disease
This trial tests whether clozapine, a medication for psychosis in Parkinson's disease, affects the immune system. It involves regular blood monitoring to help keep patients safe.
SalouëlAges 18 years+ - NCT06011460Enrolling by invitation
Observing clozapine safety for bipolar depression
This study is testing whether clozapine, a medication usually used for schizophrenia, is safe for treating hard-to-treat depression in people with bipolar disorder. It may help if you have not found relief from other treatments.
Gdansk, Pomeranian VoivodeshipAges 18–65 - NCT06596681RecruitingEarly Phase 1
Study of GA for hard-to-treat nerve pain
This early-phase trial tests a new treatment called GA for people with hard-to-treat neuropathic pain that hasn't improved with standard therapies. The goal is to see if it is safe and tolerable.
Beijing, Beijing MunicipalityAges 18–65 - NCT06969755RecruitingPhase 4
Brain scans and genetics to guide early schizophrenia treatment
This study tests whether using brain scans and genetic tests can help choose the best treatment for people early in their schizophrenia. It will check if these biomarkers can predict who will respond better to medication.
Birmingham, AlabamaAges 18–35 - NCT03094429RecruitingPhase 2/Phase 3
Testing NaBen add-on to clozapine for tough schizophrenia symptoms
This trial tests whether adding NaBen (a supplement-like medicine) to clozapine can improve “residual” symptoms in adults with difficult-to-treat schizophrenia. The study also checks safety and the best dose, using a placebo (inactive pill) for comparison.
Pasadena, CaliforniaAges 18–55 - NCT05603104RecruitingPhase 3
Medication intensification after first treatment failure in mood and psychosis
This Phase 3 study tests a stronger medication approach after your first current treatment hasn’t worked well enough. It targets people with schizophrenia, major depressive disorder, or bipolar depression who still have significant symptoms and life impact.
Ramat GanAges 18–70 - NCT05958875RecruitingPhase 4
Six-week medicine switch for schizophrenia after first treatment failure
This trial tests whether a more intensive medication approach for schizophrenia (or related conditions) helps people who didn’t improve on their first tried medicine. Participants will usually switch medicines and be compared against “treatment as usual.”
InnsbruckAges 18–70 - NCT06174116RecruitingPhase 4
Adding lumateperone to clozapine for schizophrenia
This trial tests whether adding lumateperone, an antipsychotic medication, to clozapine can improve metabolic health in people with schizophrenia. It aims to see if this combination helps with weight, blood sugar, and cholesterol levels.
Worcester, MassachusettsAges 18–65 - NCT06456983Recruiting
Maintenance ECT for hard-to-treat schizophrenia
This trial tests if regular electroconvulsive therapy (ECT) can help people whose schizophrenia has not improved with clozapine or who cannot take clozapine. Researchers will see if maintenance ECT helps prevent symptoms from returning.
AachenAges 18–75 - NCT07606014RecruitingPhase 2/Phase 3
Probiotics to Support Mental Health Treatment
This study tests whether taking special probiotics (beneficial bacteria) can help prevent weight gain and metabolic changes when starting antipsychotic medications for psychosis. You'd take probiotics daily while beginning or recently starting one of four common antipsychotic drugs.
Leeuwarden, Provincie FrieslandAges 18–65
What Clozapine is being studied for
Conditions with recruiting Clozapine studies.
Common questions
- Are there clinical trials studying Clozapine?
- Yes. Clin2 currently lists 16 recruiting studies that include Clozapine, drawn from the U.S. registry and rewritten for real people so you can see what each is testing and who it's for.
- How do I know if I qualify for a Clozapine trial?
- Each study lists its own eligibility criteria — rules about condition, age, and prior treatments. On every Clin2 trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Is Clozapine an approved treatment?
- A drug being studied in a trial may be investigational (still being tested) or already approved and being studied for a new use. Each study page explains what phase it's in. Clin2 does not provide medical advice — talk with your doctor about whether Clozapine or a specific trial is right for you.
Related treatments
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. A drug appearing here is being studied in a trial and may be investigational. Talk with your doctor about whether a specific treatment or trial is right for you.