Mitral valve repair for ATTR heart disease
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests a less invasive procedure (edge-to-edge mitral valve repair) for people with ATTR-CM and a leaky mitral valve. It aims to see if this repair can help improve symptoms compared to standard medical therapy alone.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You have been diagnosed with ATTR-CM (a type of heart disease caused by protein buildup).
- You have moderate to severe or severe mitral regurgitation (a leaky heart valve, grade 3+ or 4+).
- You are being treated for heart failure (e.g., with water pills) and other heart conditions as needed.
- Your heart team has decided that mitral valve surgery is not an option for you.
- Your heart's pumping ability (ejection fraction) is at least 20%.
- You are 18 years or older and willing to be randomly assigned to either the procedure or standard care.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
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This study tests if repairing both the mitral and tricuspid heart valves at the same time (using tiny clips) works better than fixing only the mitral valve. It is for people with severe leaking of both valves who are too high risk for open-heart surgery.
This trial tests a new device called the Capstan system to fix a leaky mitral valve (mitral regurgitation) without open-heart surgery. It may help people whose valve leak is moderate to severe and still have symptoms despite medicines.
This trial tests a minimally invasive procedure to repair a leaky mitral valve (the valve between the upper and lower chambers of your heart) in people with heart failure who haven't improved with medication alone. The procedure uses a catheter-based system inserted through the groin to replace part of the valve, potentially reducing symptoms and improving heart function.
This trial tests a new device called the Tioga TMVR system to treat moderate to severe mitral regurgitation (leaky heart valve). It is for people who cannot have standard surgery or other less invasive treatments.
This trial tests a minimally invasive procedure to repair a leaky mitral valve that only becomes severe during exercise. If you have mild to moderate leakage at rest that gets worse when you are active, this study may help determine if the repair improves your symptoms and heart function.
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