Clip repair for leaky mitral valve in ATTR-CM
Treatments studied
Part of Heart & circulation clinical trials.
This trial tests a minimally invasive procedure to fix a leaky mitral valve in people with ATTR-CM. The procedure, called edge-to-edge repair, uses a catheter to clip the valve, which may improve symptoms and quality of life.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must have a confirmed diagnosis of ATTR-CM (a specific type of heart muscle disease caused by protein buildup).
- You must have severe mitral regurgitation (leaky heart valve) — your doctor will check if it's 3+ or 4+.
- You should have symptoms like shortness of breath or fatigue, even with mild activity (NYHA class II, III, or IV).
- Your heart's pumping function must be at least 20% (a measure called ejection fraction).
- You must be 18 years or older.
- Your heart team must have decided that mitral valve surgery is not right for you, so this trial offers a less invasive option.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a clip-based procedure (TEER) to fix a severe leak in the mitral valve for people who have symptoms or heart changes but are at low to medium risk for surgery. The goal is to see if this less invasive option works well and is safe.
This trial tests a catheter-based procedure to repair a leaking mitral valve in people who are in severe heart shock and need medication support. The goal is to reduce the valve leak and see if it helps patients stabilize and recover.
This trial compares repairing both the mitral and tricuspid valves in one procedure versus repairing only the mitral valve, for people with severe leakage in both valves. The goal is to see if fixing both valves together improves symptoms and heart function better than fixing just one.
This study tests a new clip procedure (CardioClip) to repair a leaky mitral valve in people with heart failure. It aims to see if the clip can improve symptoms and heart function.
This trial tests a new device called the Capstan system to fix a leaky mitral valve (mitral regurgitation) without open-heart surgery. It may help people whose valve leak is moderate to severe and still have symptoms despite medicines.
This trial tests a minimally invasive procedure to repair a leaky mitral valve in people with a specific type of heart failure. The goal is to see if the procedure, called transcatheter edge-to-edge repair (TEER), is safe and effective in reducing symptoms and improving heart function.
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