Calming medicines for ICU patients on a breathing machine
Treatments studied
Part of Brain & nervous system, Mental health clinical trials.
This study tests a combination of two medicines (dexmedetomidine and esketamine) to help ICU patients who are on a breathing machine feel calm and have less pain. The goal is to find a safe and effective way to keep patients comfortable while they recover.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be an adult (18 years or older).
- You must be in the intensive care unit (ICU) and need a breathing machine (ventilator) for at least 24 hours.
- You must need medication to keep you calm and comfortable while on the ventilator.
- You cannot be pregnant or breastfeeding.
- You cannot have certain brain conditions (like schizophrenia, epilepsy, or Parkinson's disease) or serious heart rhythm problems.
- You cannot be allergic to the study drugs (dexmedetomidine or esketamine).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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