Dexmedetomidine for agitation during breathing tube removal
Treatments studied
Part of Brain & nervous system, Lungs & breathing, Mental health clinical trials.
This trial tests whether a sedative called dexmedetomidine can reduce agitation in ICU patients when they are being weaned off a breathing tube. If you experience restlessness or agitation during the weaning process, this medication might help you stay calm.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older and in the ICU.
- You have been on a breathing machine for at least 24 hours, and for at least 4 days but not more than 2 weeks.
- Your doctor says you are ready to start weaning from the breathing machine.
- During the weaning trial, you have an agitation score of +1 or higher on the Richmond Agitation-Sedation Scale (RASS).
- You are not allergic to dexmedetomidine.
- You do not have a very slow heart rate (below 50 beats per minute) or low blood pressure (mean arterial pressure below 60 mmHg).
- You do not have a brain or nerve condition that affects your awareness.
- You are not pregnant or breastfeeding.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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