Comparing two medicines for calming ICU patients with brain injury
Treatments studied
Part of Brain & nervous system, Injuries & trauma, Mental health clinical trials.
This study tests two medications, haloperidol and dexmedetomidine, to see which works better for reducing confusion and agitation in patients who are on a breathing machine after a traumatic brain injury. If you or a loved one is in the ICU with a brain injury and is restless or confused, this trial may help find better ways to manage those symptoms.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older
- You have a confirmed traumatic brain injury
- You are currently in the intensive care unit (ICU)
- You are on a breathing machine (mechanical ventilation)
- At least 48 hours have passed since you were admitted to the ICU
- You do not have a history of certain mental health conditions (like schizophrenia or bipolar disorder)
- You are not allergic to haloperidol or dexmedetomidine
- You do not have severe liver or kidney problems
- You are not pregnant or breastfeeding
- You do not have a history of heart rhythm problems (like prolonged QT interval)
- You were not taking long-term antipsychotic or sedative medications before coming to the ICU
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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