Treating early stage 1 type 1 diabetes in children with cell therapy and antibody
Part of Hormones & metabolism, Immune system & allergy clinical trials.
This trial tests a new combination treatment for children who have been diagnosed with stage 1 type 1 diabetes, meaning they have some markers but do not yet need insulin. The treatment uses special immune cells (Treg cells) and an antibody (anti-CD20) to try to preserve the body's ability to make insulin.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Child must be between 3 and 18 years old and weigh at least 44 pounds (20 kg).
- Must have positive antibodies (at least two different types) that show the immune system is attacking the pancreas.
- Must still produce a normal amount of insulin (fasting C-peptide at least 1.0 ng/mL) and have normal blood sugar levels.
- Cannot have used any diabetes medications, including insulin, in the past 4 weeks.
- Child must not have any other autoimmune diseases, like Hashimoto's or celiac disease.
- Must be able to come to appointments and receive intravenous treatments.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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