Testing early argipressin for shock not helped by norepinephrine
This trial tests a medicine called argipressin for people in the ICU with vasoplegic shock (very low blood pressure due to widened blood vessels) that isn't improving with high doses of the usual medicine, norepinephrine. The goal is to see if adding argipressin early helps raise blood pressure and improves outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have vasoplegic shock (wide blood vessels) confirmed by tests showing high heart output and high lactate in your blood.
- The shock is caused by an infection, surgery, bleeding, inflammation, allergic reaction, liver failure, or another similar cause.
- You need a high dose of the blood pressure medicine norepinephrine (0.25 mcg/kg/min or more) to maintain your blood pressure.
- You have had this condition for less than 12 hours.
- You or a family member can give consent, and you have French national health insurance.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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