Testing early argipressin for shock not helped by norepinephrine
Part of Blood & lymphatic, Heart & circulation clinical trials.
This trial tests a medicine called argipressin for people in the ICU with vasoplegic shock (very low blood pressure due to widened blood vessels) that isn't improving with high doses of the usual medicine, norepinephrine. The goal is to see if adding argipressin early helps raise blood pressure and improves outcomes.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have vasoplegic shock (wide blood vessels) confirmed by tests showing high heart output and high lactate in your blood.
- The shock is caused by an infection, surgery, bleeding, inflammation, allergic reaction, liver failure, or another similar cause.
- You need a high dose of the blood pressure medicine norepinephrine (0.25 mcg/kg/min or more) to maintain your blood pressure.
- You have had this condition for less than 12 hours.
- You or a family member can give consent, and you have French national health insurance.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial studies whether “blood pressure–supporting” medicines (given through a central line) work well and safely for adults in the ICU who have shock. Your team may use the results to improve care for people with low blood pressure and poor blood flow to organs.
This trial is testing a new system called Argos to see if it can measure how much blood your heart pumps more easily than current methods. It is for patients already in the ICU who need a quick change in fluids or blood pressure medicine.
This trial tests whether giving a second medicine called vasopressin early (along with norepinephrine) helps people with sepsis and low blood pressure better than waiting to use vasopressin only if norepinephrine doesn't work. It may improve blood pressure control and reduce the need for strong medicines.
This trial tests whether adding vasopressin (a hormone that narrows blood vessels) to usual care can improve recovery in patients with septic shock (a severe infection causing very low blood pressure). If you are already on a strong blood pressure medication, this study may help stabilize your condition.
This Phase 3 study tests whether starting a blood-pressure medicine earlier in the emergency room can improve outcomes for people with low blood pressure or shock. It focuses on patients who have already received enough IV fluids and meet specific blood pressure and lab findings.
This trial tests a medicine called angiotensin II to see how well it helps people whose blood pressure stays dangerously low after standard treatments for vasoplegic shock, a condition where blood vessels relax too much. If it works, it might help raise blood pressure and improve blood flow to vital organs.
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