Lung scans to see if biologic therapy reverses asthma damage
Treatments studied
Part of Blood & lymphatic, Lungs & breathing clinical trials.
This study looks at how lungs change in people with severe asthma after they start a new type of medicine called a biologic. It uses scans (MRI and CT) to see if these medicines can reverse damage in the airways and blood vessels. Healthy volunteers are also needed for comparison.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 to 80 years old.
- You have severe asthma and are about to start a biologic therapy (like Xolair, Nucala, Fasenra, Dupixent, or Tezspire) OR you are a healthy volunteer without chronic lung disease.
- If you are healthy, you must have smoked or vaped (including cannabis) for no more than 5 pack-years in your lifetime. (Pack-years = packs per day times years smoked.)
- You must be willing to have an MRI and CT scan, and be able to hold your breath during them.
- You must not have any metal in your body that can't be removed (like a pacemaker or implant).
- If you are a woman who can have children, you must agree to use effective birth control and have a negative pregnancy test. If you are a man who is sexually active, you must agree to use a condom plus another barrier method.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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