Nitric oxide gas for adults with severe breathing failure
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This study tests whether breathing in a special gas called nitric oxide can help people with moderate to severe ARDS (a severe form of lung failure that makes it hard to breathe). The gas is used to improve oxygen levels and may help patients on a ventilator recover.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Aged 18 years or older
- Diagnosed with moderate to severe ARDS (a serious lung condition causing rapid breathing and low oxygen)
- No known allergy to inhaled nitric oxide
- No history of congenital methemoglobinemia (a rare blood disorder)
- No advanced chronic lung disease (such as lung cancer, previous lung removal or lung transplant)
- No shock (very low blood pressure requiring strong medicines for more than 6 hours) or high blood pressure in the lungs
- No severe kidney problems (serum creatinine above 2.5 mg/dL)
- No major bleeding or very low platelet count (below 20,000 per microliter)
- Expected to need intensive care and a breathing machine for at least 24 hours
- No use of ECMO (heart-lung bypass) before entering the trial
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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