Study of a new drug combo before stem cell transplant for leukemia
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a combination of two drugs (SHR2554 and azacitidine) given before a stem cell transplant for people with high-risk or relapsed leukemia or MDS. The goal is to see if this approach can help make the transplant more effective and reduce the chance of the disease coming back.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are between 15 and 60 years old.
- You have been diagnosed with AML, ALL, or MDS that is high-risk or has come back after treatment.
- You are planning to receive a stem cell transplant and have a matched donor available.
- You are in generally good health, with your heart, lungs, liver, and kidneys working adequately.
- You have not had a prior stem cell transplant or taken certain investigational drugs (EZH2 inhibitors).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This trial tests a combination of a new drug (SHR2554) with another medication (azacitidine) and a conditioning regimen before a stem cell transplant. It aims to improve outcomes for high-risk or relapsed leukemia and MDS patients.
This trial tests a combination of three drugs (venetoclax, azacitidine, and homoharringtonine) followed by a donor stem cell transplant for people with intermediate- or high-risk acute myeloid leukemia (AML). The goal is to see if this approach can improve outcomes for patients who have not been treated before.
This clinical trial tests a new combination of chemotherapy drugs (called TmBU) before a stem cell transplant for people with high-risk or relapsed acute leukemia. The goal is to see if this conditioning regimen works better and is safe for patients who need a transplant.
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This trial tests a special combination of chemotherapy drugs (called a conditioning regimen) given before a half-matched stem cell transplant for older adults with acute myeloid leukemia (AML) in their first remission. The goal is to make the transplant safer and more effective for people aged 55 to 75.
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