SHR2554 plus chemotherapy for high-risk blood cancers before stem cell transplant
Part of Blood & lymphatic, Cancer, Immune system & allergy clinical trials.
This trial tests a new drug combination (SHR2554 and azacitidine) given before a stem cell transplant to treat aggressive leukemias, lymphomas, or bone marrow disorders. The goal is to improve survival and reduce cancer recurrence in patients with high-risk or hard-to-treat disease.
Summary written for real people, not researchers, by Clin2.
Who can take part
- Age 15–60 years old
- Diagnosed with AML (acute myeloid leukemia), ALL (acute lymphoblastic leukemia), T-ALL, or MDS (bone marrow disorder) that is high-risk or has not responded to standard treatment
- Have an HLA-matched donor available for stem cell transplant (usually a sibling or matched unrelated donor)
- Healthy enough to tolerate intense chemotherapy (good heart, lung, liver, and kidney function)
- Never had a previous stem cell transplant or treatment with an EZH2 inhibitor drug
- No active infection or recent heart attack
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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