Clinical trials
Moderate to Severe Traumatic Brain Injury clinical trials
Below are recruiting moderate to severe traumatic brain injury clinical trials, each written for real people, not researchers. We’re tracking 99 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05236010Recruiting
Brain stimulation plus cognitive training for mild TBI memory and thinking
This trial studies whether brain stimulation through the scalp can improve cognitive (thinking and memory) training in people with chronic mild traumatic brain injury (TBI). Participants train on thinking tasks while receiving a targeted “control network neuromodulation” approach to see if it enhances training results.
Minneapolis, MinnesotaAges 18–59 - NCT06065046RecruitingPhase 2
Baricitinib for traumatic brain bleeding
This trial tests if baricitinib, an anti-inflammatory drug, can help people with bleeding in the brain from a head injury. It is for adults with moderate to severe traumatic brain injury who are not immediately having surgery.
Xi'an, ShaanxiAges 18–80 - NCT05647044RecruitingPhase 1
Brain stimulation to reduce impulsivity and suicidal thoughts after mild TBI
This early-stage study tests whether a noninvasive brain stimulation treatment (called iTBS) can reduce impulsivity and suicidal thoughts in Veterans who have had a mild traumatic brain injury (mTBI) and recent suicidal thinking. If you qualify, you may be offered a monitored treatment plan and assessments for safety and symptom changes.
Hines, IllinoisAges 22–65 - NCT07404761Recruiting
Moving your arm after stroke or TBI
This study tests a device that uses mild electrical pulses and augmented reality (a computer overlay on real life) to help people who have arm or hand weakness after a recent stroke or brain injury regain movement.
HaifaAges 18 years+ - NCT07357090Recruiting
Carbon dioxide and brain waste clearance trial
This trial tests if breathing in carbon dioxide helps the brain clear waste. It may show how the brain heals after a traumatic brain injury (TBI).
Albuquerque, New MexicoAges 18–82 - NCT07356167Recruiting
Neurosensory training for mild brain injury symptoms
This study tests a special training program that uses sound and head movements to help people with long-lasting symptoms after a mild brain injury or sudden sensory event. The goal is to see if this 'neurosensory' training can reduce problems like dizziness, headache, and brain fog.
Miami, FloridaAges 18 years+ - NCT06958406Recruiting
Brain-heart connection after head injury
This study uses brain scans (MRI) to understand how a traumatic brain injury can affect the heart. It may help find better ways to treat the brain-heart connection after a head injury.
ShanghaiAges 18–80 - NCT06866691RecruitingPhase 4
Seizure prevention after traumatic brain injury
This trial tests two medicines, levetiracetam and lacosamide, to see which works better at preventing seizures in people who have had a traumatic brain injury. The goal is to find the safest and most effective way to protect your brain after injury.
Winston-Salem, North CarolinaAges 18 years+ - NCT07269457RecruitingPhase 2
Vitamin D3 for recovery after mild to moderate brain injury
This trial tests if taking vitamin D3 can help reduce swelling and speed up recovery after a mild to moderate traumatic brain injury. It is for people who have low vitamin D levels.
LagosAges 18–65 - NCT04349852Recruiting
Memory and attention training for adults after brain injury
This trial tests a therapy that helps improve verbal working memory and attention in adults who had a traumatic brain injury (TBI). It may help by training thinking skills that are often affected after an injury, but it’s only for people who meet timing and mental health substance-use requirements.
New York, New YorkAges 18 years+ - NCT05682677Recruiting
Brain stimulation plus cognitive training for depression after mild head injury
This study tests whether a combination of brain stimulation and cognitive training can reduce depression symptoms in people who have ongoing mild traumatic brain injury (TBI). It may help by targeting both mood and thinking/processing skills affected after mTBI.
La Jolla, CaliforniaAges 18–65 - NCT07230002Recruiting
Navigating in virtual worlds after brain injury
This study looks at how people who had a moderate or severe traumatic brain injury at least 3 months ago walk and navigate in complex virtual environments. Participants will use virtual reality to test their movement strategies.
RennesAges 18–55 - NCT04400266RecruitingPhase 4
Buspirone and melatonin for depression after a brain injury
This trial studies whether the medicines buspirone and melatonin can reduce depression symptoms in people who had a mild or moderate traumatic brain injury (TBI) at least 3 months ago. It may help if you have ongoing depression after TBI and can safely take study medications and attend regular visits, including MRI scans.
Boston, MassachusettsAges 18–64 - NCT07180277RecruitingPhase 4
Steroid treatment for moderate to severe brain injury
This trial tests a steroid medicine called methylprednisolone to see if it can help people who have had a moderate to severe brain injury. It aims to reduce swelling in the brain and possibly improve recovery.
Suzhou, JiangsuAges 18–65 - NCT03819608Recruiting
Brain stimulation and rehab after mild concussion with PTSD or cognitive issues
This trial studies whether brain stimulation plus targeted brain rehabilitation can improve symptoms after a mild concussion (mTBI). You may be invited if your concussion happened at least 3 months ago and your symptoms are affecting thinking or mood, with or without PTSD.
Chicago, IllinoisAges 18–80 - NCT07097792Recruiting
Concussion recovery support program for headaches
This study tests a support program for young people who have had a concussion and are still having headaches. It aims to help them recover and feel better.
Seattle, WashingtonAges 18–29 - NCT07071350RecruitingPhase 2/Phase 3
Optimizing heart rate for persistent concussion symptoms in military veterans
This trial tests a treatment designed to improve heart rate variability, which may help reduce long-term concussion symptoms like headaches, dizziness, and trouble sleeping. It is for military veterans who have had a mild concussion more than a year ago and still have ongoing symptoms.
Richmond, VirginiaAges 18 years+ - NCT05741411Recruiting
Text-and-phone support after concussion for teens
This study tests whether a phone-based (mHealth) handoff and follow-up can help teens after a concussion, especially those at higher risk of long-lasting symptoms. It uses smartphone check-ins and coordination between emergency and specialty care.
Philadelphia, PennsylvaniaAges 13–18 - NCT07606300Recruiting
Light Training to Help Light Sensitivity After Head Injury
This trial tests whether a training program using colored light targets can help reduce light sensitivity (photophobia) that some people experience after a traumatic brain injury. The training involves focusing your eyes on lights during several visits.
Columbus, OhioAges 18–80 - NCT06956404Recruiting
Light therapy for older adults with traumatic brain injury
This study tests whether a painless light therapy applied to the head can help older adults (55-85) who had a moderate or severe traumatic brain injury 1-2 years ago. It aims to see if the treatment improves thinking and memory.
New York, New YorkAges 55–85 - NCT06901310Enrolling by invitation
Hyperbaric oxygen for mild head injuries in combat athletes
This study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a special chamber) helps men recover from mild head injuries better than the current standard care (rest). It is for male unarmed combat athletes who have been suspended for a head injury.
Marshfield, WisconsinAges 18 years+ - NCT06871124Recruiting
Early brain stimulation for traumatic brain injury
This study tests whether early brain stimulation can help recovery after a moderate to severe traumatic brain injury (TBI). It might help improve thinking and awareness in patients who can already speak and follow directions.
Cincinnati, OhioAges 18–80 - NCT06839079Recruiting
Brain training for trauma survivors with head injury
This study tests a cognitive rehabilitation program for people with traumatic brain injury who have also experienced war, violence, or other trauma. It aims to improve memory and thinking skills using exercises and strategies.
Boston, MassachusettsAges 18–65 - NCT06836856RecruitingPhase 1/Phase 2
Beta blockers after traumatic brain injury: a study
This trial tests whether giving a beta blocker drug after a moderate or severe traumatic brain injury can improve recovery. It is for patients who have a brain injury but only minor or no other injuries.
ZagazigAges 18–75
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Common questions
- Are there clinical trials for moderate to severe traumatic brain injury?
- Yes. Clin2 currently lists 99 recruiting moderate to severe traumatic brain injury studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a moderate to severe traumatic brain injury trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a moderate to severe traumatic brain injury trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.