Clinical trials
Large Vessel Occlusion clinical trials
Below are recruiting large vessel occlusion clinical trials, each written for real people, not researchers. We’re tracking 55 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05659160Recruiting
Triage approach for certain strokes from blocked large brain arteries
This trial studies a way to sort and treat people with a specific type of acute ischemic stroke (caused by a blockage in a large brain artery). It may help doctors choose the best next steps—either a procedure or medication—faster and more appropriately.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06200753Recruiting
Late stroke treatment study for large vessel blockages
This study looks at patients who had an ischemic stroke (a type of stroke caused by a blood clot) more than 24 hours ago and have a blockage in a large brain artery. It compares outcomes for those who get a procedure to remove the clot versus those who get only medical treatment.
Tianjin, Tianjin MunicipalityAges Any age - NCT06654375Recruiting
Late stroke treatment with clot removal or medication
This trial compares a procedure to remove a large blood clot from the brain (thrombectomy) with standard medical care for people who had a stroke 24 to 72 hours ago but still have some blood flow around the clot. It aims to see if the procedure can help improve recovery even when started later than usual.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT07594314RecruitingPhase 2/Phase 3
Minocycline after stroke clot removal surgery
This trial tests whether minocycline, an antibiotic, can reduce brain damage when given after successful clot removal surgery for acute stroke. The goal is to see if this medication helps patients recover better.
Wuhan, HubeiAges 18 years+ - NCT06727006Recruiting
Rescue stenting and clot-dissolving medicine for severe stroke
This trial tests whether using a stent plus a clot-dissolving drug can improve outcomes for people with a large-vessel stroke who are having a procedure to remove the clot. It is designed for patients who can receive treatment within 24 hours of their first symptoms.
Bergamo, ItalyAges 18 years+ - NCT07552610Recruiting
Sivelestat sodium added to clot removal surgery for stroke
This trial tests whether adding a medication called sivelestat sodium to emergency clot removal surgery (mechanical thrombectomy) can improve outcomes in patients with a specific type of stroke caused by a large blood clot in the front part of the brain. The goal is to see if this combination treatment leads to better recovery.
Weifang, ShandongAges 18–80 - NCT07231380Recruiting
Comparing two ways to remove clots in stroke
This study tests two methods of removing a large blood clot from a brain artery during stroke. The goal is to see which method helps restore blood flow faster and more safely.
Nashville, TennesseeAges 18 years+ - NCT06963489Recruiting
Stroke biobank study for large vessel blockage
This study collects blood and tissue samples from people who had a stroke caused by a blockage in a large artery in the brain. The goal is to learn more about the condition by studying these samples over time.
Wuhu, AnhuiAges Any age - NCT07090941Recruiting
Clot removal for severe basilar artery stroke
This trial tests a procedure to remove a blood clot from the main artery at the back of the brain (basilar artery) in people who have a large stroke. The goal is to see if this treatment can improve recovery even when the stroke damage is bigger than usual.
Hefei, AnhuiAges 18 years+ - NCT06210633Recruiting
Clot removal trial for very large strokes
This trial tests a procedure called endovascular thrombectomy (clot removal through a catheter) for people with very large strokes. It aims to see if removing the clot can help even when a large part of the brain is already damaged.
Xiangtan, HunanAges 18 years+ - NCT07740018Recruiting
Stroke treatment study for blocked brain arteries
This study looks at how well a procedure to remove blood clots from blocked brain arteries works for people who have had a stroke. It aims to see what factors help people recover better, which could help guide treatment decisions.
SohagAges 18–80 - NCT07727395RecruitingPhase 3
Clot-busting drug after successful clot removal for stroke
This trial tests whether giving a clot-busting drug (alteplase) directly into the brain artery after a successful clot removal improves recovery in people with severe stroke. It is for patients who have had a thrombectomy and still have a large blocked artery in the front of the brain.
An GiangAges 18 years+ - NCT06633809Recruiting
Treating minor stroke with large artery blockage
This study tests whether a specific treatment (likely endovascular therapy) helps people who have a minor stroke caused by a blockage in a large brain artery. If you are eligible, you may receive this treatment within 24 hours of your stroke to try to improve your recovery.
Hangzhou, ZhejiangAges 18 years+ - NCT06457217Recruiting
MRSI for minor stroke with large artery blockage
This study uses a special MRI technique (called MRSI) to look at brain chemistry in people who have had a minor stroke due to a blocked large artery. The goal is to see if the scan can help doctors better understand the stroke and guide treatment decisions.
Shanghai, Shanghai MunicipalityAges 18–100 - NCT07626450Recruiting
Hyperbaric oxygen after stroke clot removal treatment
This study tests whether hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) can help recovery after emergency clot-removal surgery for large blood vessel strokes. The goal is to see if extra oxygen can reduce brain damage and improve outcomes.
Beijing, Beijing MunicipalityAges 18–80 - NCT06211712Recruiting
Drug plus clot removal for large vessel stroke
This study tests whether adding a drug called human urinary kallidinogenase to standard clot-removal therapy helps people recover better after a large-vessel stroke. If you qualify, you would receive the drug or a placebo by IV along with the procedure, and doctors will monitor your recovery.
ShanghaiAges 18 years+ - NCT06559475Recruiting
Testing a new aspiration catheter for large vessel stroke
This trial tests a new catheter (Super-Bore 8/7F) to remove blood clots in people having a major stroke caused by a blocked large artery in the brain. The goal is to see if it is safe and effective at restoring blood flow when used within 24 hours of stroke symptoms starting.
Hefei, AnhuiAges 18 years+ - NCT07550296RecruitingPhase 2
Second IV Clot-Dissolving Treatment for Major Stroke
This trial tests giving a second dose of an IV clot-dissolving medicine (prourokinase) to patients who had a stroke from a large clot but didn't improve enough after the first dose. The goal is to see if a second dose within 6 hours of stroke onset can help more patients recover.
Shenyang, None SelectedAges 18–80 - NCT07516522RecruitingPhase 2
Steroid injection during stroke clot removal surgery
This trial tests whether injecting a steroid (methylprednisolone) directly into brain blood vessels after removing a stroke clot helps reduce brain swelling and improve recovery. You would be eligible if you had a large clot stroke in the front part of your brain that was successfully removed within the past 24 hours.
Xi'an, ShaanxiAges 18–80 - NCT07519044RecruitingPhase 4
GM1 drug added to clot removal for acute stroke
This study tests whether adding a medicine called GM1 to emergency clot-removal surgery helps people recover better from sudden strokes caused by blood clots in major brain arteries. GM1 may protect brain cells from damage during and after the stroke.
Beijing, Beijing MunicipalityAges 18–80 - NCT06301412RecruitingPhase 3
Cooling plus clot removal for acute stroke
This trial tests whether cooling the body down (hypothermia) combined with a clot removal procedure (thrombectomy) helps people recover better from a large-artery stroke. You may be eligible if you have a moderate-to-severe stroke and can be treated within 24 hours of when you were last seen well.
Freiburg im BreisgauAges 18 years+ - NCT07509645RecruitingPhase 3
Testing a new drug with clot removal for severe back-of-the-brain stroke
This trial checks if adding an interleukin-6 receptor inhibitor (a drug that reduces inflammation) to standard emergency clot removal can improve recovery for people with a severe stroke affecting the back part of the brain (posterior circulation). It is for patients who need urgent treatment within 24 hours of symptom onset.
Huaibei, AnhuiAges 18 years+ - NCT05864638Recruiting
Registry study of clot-removal treatment for acute stroke
This study records outcomes for people having an acute ischemic stroke treated with an endovascular (catheter-based) procedure. It may help doctors understand how clot-removal treatment works in different patients and hospitals.
ShanghaiAges Any age - NCT07404852Recruiting
Vagus nerve stimulation for reducing inflammation after stroke
This trial tests whether a non-invasive device that stimulates the vagus nerve can reduce inflammation and brain injury after a stroke caused by a large blood clot.
St Louis, MissouriAges 18–99
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Common questions
- Are there clinical trials for large vessel occlusion?
- Yes. Clin2 currently lists 55 recruiting large vessel occlusion studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a large vessel occlusion trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a large vessel occlusion trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.