Clinical trials
Large Vessel Occlusion clinical trials
Below are recruiting large vessel occlusion clinical trials, each written for real people, not researchers. We’re tracking 55 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07231380Recruiting
Comparing two ways to remove clots in stroke
This study tests two methods of removing a large blood clot from a brain artery during stroke. The goal is to see which method helps restore blood flow faster and more safely.
Nashville, TennesseeAges 18 years+ - NCT05659160Recruiting
Triage approach for certain strokes from blocked large brain arteries
This trial studies a way to sort and treat people with a specific type of acute ischemic stroke (caused by a blockage in a large brain artery). It may help doctors choose the best next steps—either a procedure or medication—faster and more appropriately.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06200753Recruiting
Late stroke treatment study for large vessel blockages
This study looks at patients who had an ischemic stroke (a type of stroke caused by a blood clot) more than 24 hours ago and have a blockage in a large brain artery. It compares outcomes for those who get a procedure to remove the clot versus those who get only medical treatment.
Tianjin, Tianjin MunicipalityAges Any age - NCT06456437Recruiting
Testing a new technique after clot removal for stroke
This trial tests if a special technique called 'ischemic post-conditioning' can improve recovery after a large vessel stroke. It is for people who have had a major blockage in a brain artery that was successfully opened with a clot retrieval procedure.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06654375Recruiting
Late stroke treatment with clot removal or medication
This trial compares a procedure to remove a large blood clot from the brain (thrombectomy) with standard medical care for people who had a stroke 24 to 72 hours ago but still have some blood flow around the clot. It aims to see if the procedure can help improve recovery even when started later than usual.
Tianjin, Tianjin MunicipalityAges 18 years+ - NCT06727006Recruiting
Rescue stenting and clot-dissolving medicine for severe stroke
This trial tests whether using a stent plus a clot-dissolving drug can improve outcomes for people with a large-vessel stroke who are having a procedure to remove the clot. It is designed for patients who can receive treatment within 24 hours of their first symptoms.
Bergamo, ItalyAges 18 years+ - NCT06963489Recruiting
Stroke biobank study for large vessel blockage
This study collects blood and tissue samples from people who had a stroke caused by a blockage in a large artery in the brain. The goal is to learn more about the condition by studying these samples over time.
Wuhu, AnhuiAges Any age - NCT07552610Recruiting
Sivelestat sodium added to clot removal surgery for stroke
This trial tests whether adding a medication called sivelestat sodium to emergency clot removal surgery (mechanical thrombectomy) can improve outcomes in patients with a specific type of stroke caused by a large blood clot in the front part of the brain. The goal is to see if this combination treatment leads to better recovery.
Weifang, ShandongAges 18–80 - NCT07594314RecruitingPhase 2/Phase 3
Minocycline after stroke clot removal surgery
This trial tests whether minocycline, an antibiotic, can reduce brain damage when given after successful clot removal surgery for acute stroke. The goal is to see if this medication helps patients recover better.
Wuhan, HubeiAges 18 years+ - NCT07090941Recruiting
Clot removal for severe basilar artery stroke
This trial tests a procedure to remove a blood clot from the main artery at the back of the brain (basilar artery) in people who have a large stroke. The goal is to see if this treatment can improve recovery even when the stroke damage is bigger than usual.
Haikou, HainanAges 18 years+ - NCT06210633Recruiting
Clot removal trial for very large strokes
This trial tests a procedure called endovascular thrombectomy (clot removal through a catheter) for people with very large strokes. It aims to see if removing the clot can help even when a large part of the brain is already damaged.
Xiangtan, HunanAges 18 years+ - NCT07253181RecruitingPhase 3
Stroke clot-busting drug before transfer for artery clearing
This trial tests whether giving a clot-busting drug (tenecteplase) before transferring you to a hospital that can do a procedure to remove the clot improves outcomes for people who had a stroke up to 24 hours earlier. You may qualify if you have a blockage in a large artery in the front of your brain and can still get the procedure.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05723926Recruiting
Carotid implants to help prevent stroke repeat in atrial fibrillation
This trial tests whether placing a carotid implant can reduce the chance of having another stroke in people with atrial fibrillation who are already taking blood thinners. It aims to prevent stroke recurrence while you continue prescribed anticoagulation.
Rockford, IllinoisAges 18 years+ - NCT06904911RecruitingPhase 2
Study of tenecteplase into the artery after clot removal for stroke
This study tests a clot-dissolving drug called tenecteplase given directly into the artery after a mechanical thrombectomy (clot removal). The goal is to see if it helps improve blood flow to the small vessels in the brain after the main clot is removed.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07727395RecruitingPhase 3
Clot-busting drug after successful clot removal for stroke
This trial tests whether giving a clot-busting drug (alteplase) directly into the brain artery after a successful clot removal improves recovery in people with severe stroke. It is for patients who have had a thrombectomy and still have a large blocked artery in the front of the brain.
An GiangAges 18 years+ - NCT06370182Recruiting
New catheter for clot removal in disabling stroke
This trial tests a new catheter device (ANA Funnel) for removing large blood clots from the brain in people having a disabling stroke. The goal is to see if it safely removes clots better than standard treatment.
Jacksonville, FloridaAges 22–85 - NCT06464731Recruiting
Clot removal for mild stroke due to large artery blockage
This trial tests whether removing a blood clot from a large brain artery (using a catheter through the groin) can help people with mild stroke symptoms. It is for patients whose stroke started within the last 24 hours and who have a blockage in the front part of the brain's blood supply.
Zhangzhou, FujianAges 18–80 - NCT07740018Recruiting
Stroke treatment study for blocked brain arteries
This study looks at how well a procedure to remove blood clots from blocked brain arteries works for people who have had a stroke. It aims to see what factors help people recover better, which could help guide treatment decisions.
SohagAges 18–80 - NCT05199662RecruitingPhase 3
IV clot-busting medicine for stroke when standard options don’t fit
This trial tests whether giving IV TNK (tenecteplase) plus standard stroke care can improve outcomes in some people who have a new stroke but cannot get alteplase (another clot-busting drug) and do not have a large blocked artery that can be treated with a procedure. It’s meant for strokes with “mismatch” findings on scans that suggest salvageable brain tissue.
Porto Alegre, Rio Grande do SulAges 18 years+ - NCT05864638Recruiting
Registry study of clot-removal treatment for acute stroke
This study records outcomes for people having an acute ischemic stroke treated with an endovascular (catheter-based) procedure. It may help doctors understand how clot-removal treatment works in different patients and hospitals.
ShanghaiAges Any age - NCT06143488Recruiting
Clot removal vs. best medicine for mild stroke with large vessel blockage
This trial tests whether removing a blood clot from a large brain artery is better than standard medical care for people who have a mild stroke (NIHSS score 2-5) but still have symptoms like trouble speaking, weakness, or confusion. It is for patients who can be treated within 24 hours of their last known well time.
Wuhu, AnhuiAges 18 years+ - NCT06211712Recruiting
Drug plus clot removal for large vessel stroke
This study tests whether adding a drug called human urinary kallidinogenase to standard clot-removal therapy helps people recover better after a large-vessel stroke. If you qualify, you would receive the drug or a placebo by IV along with the procedure, and doctors will monitor your recovery.
ShanghaiAges 18 years+ - NCT06301412RecruitingPhase 3
Cooling plus clot removal for acute stroke
This trial tests whether cooling the body down (hypothermia) combined with a clot removal procedure (thrombectomy) helps people recover better from a large-artery stroke. You may be eligible if you have a moderate-to-severe stroke and can be treated within 24 hours of when you were last seen well.
Freiburg im BreisgauAges 18 years+ - NCT06383182Recruiting
Study of blood markers after stroke artery treatment
This study looks at how certain proteins in the blood change after a procedure to remove a large blockage in a brain artery. The goal is to better understand recovery after stroke treatment.
ShenyangAges 18–80
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Common questions
- Are there clinical trials for large vessel occlusion?
- Yes. Clin2 currently lists 55 recruiting large vessel occlusion studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a large vessel occlusion trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a large vessel occlusion trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.