Immune cell treatment for severe autoimmune disease
Part of Bones, joints & muscles, Brain & nervous system, Immune system & allergy, Kidney & urinary, Skin, Women’s health & pregnancy clinical trials.
This trial tests a new treatment called BAFF CAR-T cells (LMY-922) for people with severe autoimmune diseases like rheumatoid arthritis, lupus, dermatomyositis, or systemic sclerosis that have not improved with standard therapies. The treatment uses your own immune cells, modified to target and help calm the overactive immune response causing your disease. It aims to reduce symptoms and possibly provide long-term improvement.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You must be between 16 and 75 years old.
- You need to have one of these autoimmune conditions that has not responded to standard treatments: rheumatoid arthritis, lupus, dermatomyositis, or systemic sclerosis.
- Your disease must be active, for example, you have joint swelling or skin/muscle symptoms that are ongoing.
- You must have tried several standard treatments (like methotrexate, steroids, mycophenolate, or biologics) and they were not effective.
- Your organs (kidneys, heart, lungs, liver) must be working well enough, as shown by blood tests and heart/lung checks.
- If you are of childbearing age, you must agree to use effective birth control for at least a year after the treatment. Men must also use contraception and not donate sperm.
- You must be free of infections, certain heart problems, and other active cancers.
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
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