Carbon dioxide removal plus breathing support for severe COPD
Part of Hormones & metabolism, Lungs & breathing clinical trials.
This study tests a treatment that removes carbon dioxide from the blood (using a machine) in addition to noninvasive ventilation (a breathing mask) for people with severe COPD flare-ups who cannot have a breathing tube placed. The goal is to see if this extra treatment helps improve blood acidity and carbon dioxide levels.
Summary written for real people, not researchers, by Clin2.
Who can take part
- You are 18 years or older.
- You have a confirmed diagnosis of COPD (chronic obstructive pulmonary disease).
- You are having a sudden worsening of your COPD symptoms (increased shortness of breath, cough, or phlegm).
- Your blood is too acidic (pH < 7.30) and carbon dioxide is too high (PaCO2 > 50 mmHg), requiring noninvasive ventilation.
- You are not eligible for endotracheal intubation (breathing tube), either by medical decision or your own choice.
- Even after 4 hours of noninvasive ventilation, your blood is still too acidic (pH < 7.30) and carbon dioxide remains high (PaCO2 > 45 mmHg).
Quick eligibility check
Answer a few plain-language questions, based on this study's own requirements, to get a preliminary sense of fit.
Similar studies
Other trials that look related to this one.
This research looks back at hospital records of people with a COPD flare-up who received breathing support. The goal is to find the best ways to use oxygen and breathing machines for future patients.
This study tests an “extra-CO2 removal” breathing support approach to help protect the lungs in people with moderate ARDS, a serious lung injury. You would be on a ventilator for a short time, and the team would check whether this approach improves breathing outcomes while aiming to be safer for the lungs.
This study tests a machine that removes carbon dioxide from your blood (called extracorporeal carbon dioxide removal or ECCO2R) to help protect your lungs from further damage while on a breathing machine. It may be an option if you have severe ARDS and your breathing machine settings are very high.
This trial studies how different breathing support strategies affect people with COPD who have high carbon dioxide (CO2) in their blood. It may help care teams choose safer respiratory support after a breathing machine is stopped.
This trial tests special facemasks that help remove carbon dioxide from the blood during noninvasive breathing support (like a CPAP or BiPAP mask). It is for people who have a sudden breathing problem with high carbon dioxide and low blood pH.
This trial tests whether a device that helps you breathe during exercise can improve how long you can keep going. It aims to help people with severe COPD who have too much carbon dioxide in their blood or who get easily exhausted.
Hear when a new Acute Exacerbation of Chronic Obstructive Pulmonary Disease trial opens
We’ll email you when one opens — at most once a week, no account needed, unsubscribe anytime.