Clinical trials
Adaptation clinical trials
Below are recruiting adaptation clinical trials, each written for real people, not researchers. We’re tracking 654 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04885569Recruiting
Therapy program to help prevent relapse in substance use
This trial tests a culturally adapted therapy combining motivational interviewing, CBT (talk-based skills therapy), and mindfulness to help people avoid relapse after detox. It may help you build coping tools and stay engaged in treatment.
LahoreAges 18 years+ - NCT04898790Recruiting
Testing ways to improve thinking after bone marrow transplant
This study looks at whether a physical activity program and related study measures can improve thinking and memory in older adults around the time of a stem cell transplant. If you qualify and participate, the team will compare outcomes between groups to see what approach works best.
Omaha, NebraskaAges 19 years+ - NCT04900623RecruitingPhase 2
Using HPV blood test to guide treatment for HPV throat cancer
This Phase 2 study tests a “risk-adapted” treatment plan for HPV-related throat cancer, using an HPV DNA blood test to help decide how treatment is done. If your baseline blood test shows detectable HPV DNA, the study may help tailor therapy to your risk and potentially improve outcomes while limiting unnecessary treatment.
Boston, MassachusettsAges 22 years+ - NCT04903951RecruitingPhase 2
Check if early breathing support after stroke helps sleep apnea
This trial tests whether starting a breathing-support treatment soon after a first stroke improves outcomes in people who also have sleep apnea. It may help reduce complications and support recovery if you meet the specific timing and health criteria.
Matosinhos MunicipalityAges 18–80 - NCT07117630RecruitingPhase 2
A new drug combo for advanced breast cancer after standard treatment
This trial tests a new drug combination for women with a certain type of advanced breast cancer (HR-positive, HER2-negative) that has worsened after standard treatments like CDK4/6 inhibitors and hormone therapy. It aims to see if the combination can help when other options have stopped working.
ShanghaiAges 18 years+ - NCT04966793Recruiting
Study bacteria patterns in bronchiectasis and how they change
This study looks at how bacteria live in the lungs of people with bronchiectasis and how they may adapt over time. It may help researchers understand why infections keep coming back and how to better manage chronic lung colonization.
Hangzhou, ZhejiangAges 18–79 - NCT04991103RecruitingPhase 2
Testing delaying stem cell transplant after early myeloma response
This Phase 2 study tests whether people with newly diagnosed multiple myeloma can safely delay or avoid an immediate stem cell transplant if they respond well to early treatment. It aims to see if this “response-adapted” approach can still control the disease while reducing the need for upfront transplant for some patients.
Birmingham, AlabamaAges 18 years+ - NCT05029531RecruitingPhase 3
Immuno-chemotherapy for infants with B-lineage ALL
This trial tests a combination of medicines (immunotherapy plus chemotherapy) in babies diagnosed with a type of leukemia called B-lineage acute lymphoblastic leukemia (ALL). It aims to improve how well treatment works and is delivered safely in very young children.
Moscow, Samory-Mashela,1Ages 1 day–12 months - NCT05030207Recruiting
Test a new CT scan method for lung cancer radiation planning
This study tests whether a real-time, breathing-adapted CT scan (called 4DCT) can be done safely and work well for planning radiation treatment for lung cancer. It may help make radiation planning more accurate while checking if the scan process is practical for patients.
Blacktown, New South WalesAges 18 years+ - NCT05056350Recruiting
Coaching to help you return to work after breast cancer
This study tests whether a tailored coaching program can help people with non-metastatic breast cancer return to work in a way that fits their physical and emotional needs. It’s for people who have finished most cancer treatments and are dealing with job-related difficulties.
MontpellierAges 18 years+ - NCT05070013Recruiting
Brain stimulation to improve sleep in people with Parkinson’s disease
This study tests an adaptive brain stimulation device to help restore better sleep in people with Parkinson’s disease. You may be eligible if your Parkinson’s motor symptoms are severe despite best medical treatment and you are already being considered for a specific deep brain stimulation surgery.
Omaha, NebraskaAges 18–80 - NCT05080556RecruitingPhase 2
Adaptive chemotherapy for ovarian cancer after platinum and PARP
This trial tests a personalized (adaptive) chemotherapy plan for people with certain types of ovarian/fallopian tube/peritoneal cancer who already had platinum chemotherapy and a PARP inhibitor. It’s for patients whose cancer came back after (or still responds to) prior platinum treatment and may help delay disease progression.
LondonAges 18 years+ - NCT05088863Recruiting
Diet survey about how health label messages change eating
This study looks at how people change (or don’t change) what they eat after seeing health-related messages. You may be asked to provide consent, follow study instructions, and try a specific food item for the survey.
Winnipeg, ManitobaAges 18 years+ - NCT05091645Recruiting
Testing a Greek version of a frailty screening for hip fracture patients
This trial checks whether a translated and culturally adapted questionnaire (called the Groningen Frailty Indicator) works well for people age 65+ who have a hip fracture and are having surgery. It may help care teams better understand frailty and plan support after surgery.
LarissaAges 65 years+ - NCT05125822Recruiting
Study of how bodies change weight in youth with obesity
This study looks at what helps or drives weight changes in children and teens with obesity. You may be asked about growth and body changes to better understand why weight changes happen and how to manage them.
Chicago, IllinoisAges 11–15 - NCT05137119RecruitingPhase 4
Adaptive study of treatments for staph bloodstream infection
This trial tests the best treatment approach for bloodstream infections caused by Staphylococcus aureus (“S. aureus”). It uses a flexible design to decide which treatment track you fit into, and may help improve recovery while avoiding unnecessary medications.
Houston, TexasAges Any age - NCT05165537Recruiting
MRI scan to measure body chemicals without needles
This study tests a new way to use MRI to measure certain body chemicals (metabolite levels) without injections. If you are healthy and can safely do a long MRI scan, you may be able to help evaluate whether the method works reliably.
Bern, PhDAges 18 years+ - NCT05178914Recruiting
Testing heart pain treatment guided by blood-flow measurements
This study looks at how to personalize treatment for people with angina (chest pain) by measuring how well blood flows through the heart’s small vessels and the main arteries during a procedure. It may help doctors choose the right approach after your coronary angiography (heart artery imaging).
La TroncheAges 18 years+ - NCT05183074Recruiting
MRI-guided focused radiation for prostate cancer
This trial tests a newer way to plan and deliver radiation for prostate cancer using real-time MRI guidance. It may help by aiming high-dose treatment precisely while treating nearby disease and (in some cases) limited metastatic spots.
Beijing, Beijing MunicipalityAges 18 years+ - NCT05255354Recruiting
Testing blood cancer DNA monitoring during CAR-T treatment
This trial checks whether a blood test that looks for small amounts of cancer DNA can accurately track minimal residual disease (MRD) in lymphoma patients during CAR-T therapy. It may help doctors detect relapse earlier and better judge how well CAR-T is working.
Palo Alto, CaliforniaAges 18 years+ - NCT05268614RecruitingPhase 2
Risk-based reduced chemo and radiation for HPV throat cancer
This trial tests whether using a lower intensity (reduced) chemo-radiation plan can work for some people with HPV-related oropharyngeal (throat) cancer without losing effectiveness. It may help reduce side effects while still controlling the cancer.
Gainesville, FloridaAges 18 years+ - NCT05300607Recruiting
Arabic rotator cuff shoulder questionnaire for tendon tears
This study tests an Arabic version of a shoulder questionnaire for people with rotator cuff problems. It may help doctors better understand symptoms and track how well treatment works using a tool written in your language.
CairoAges 18–60 - NCT05327699RecruitingEarly Phase 1
Ketamine study for depression with reduced pleasure
This early-phase study tests whether ketamine can help people with major depression who have trouble feeling pleasure. It also studies how the brain may change in response to stress, to better understand who might respond to treatment.
Atlanta, GeorgiaAges 18–65 - NCT05336201RecruitingPhase 2
Brain training program for teens with sickle cell disease
This Phase 2 study tests a cognitive (thinking) training program to help teens with sickle cell disease prepare for the changes in their care as they grow older. It may help with skills like learning, attention, and planning for transition to adult care.
Birmingham, AlabamaAges 10–18
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Common questions
- Are there clinical trials for adaptation?
- Yes. Clin2 currently lists 654 recruiting adaptation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a adaptation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a adaptation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.