Advanced or Metastatic Breast Cancer clinical trials

New treatment for metastatic nasopharyngeal cancer before chemotherapy

This trial tests a new treatment for people with advanced nasopharyngeal cancer that has spread (stage IVb) and who have not yet had chemotherapy. It aims to see if the experimental treatment is safe and effective as a first option.

Study of durvalumab and olaparib for endometrial cancer

This study looks at how well two drugs, durvalumab and olaparib, work together after initial chemotherapy for advanced or recurrent endometrial cancer. It may help patients who have not had many treatment options before.

Fecal transplant and diet change for Crohn's disease

This trial tests whether a fecal transplant (putting healthy bacteria into your gut) combined with dietary changes can help control active Crohn's disease. It is for people who need stronger treatments or have stopped responding to their current therapy.

Testing SHR-A2102 for advanced solid tumors

This trial tests a new drug called SHR-A2102, alone or with other cancer treatments, for people with advanced solid tumors that haven't responded well to standard therapies. It aims to see if the drug can shrink tumors or slow their growth.

Blood test to predict chemo-immunotherapy response in lung cancer

This trial tests whether a blood test (ctDNA) can help predict how well a combination of chemotherapy and immunotherapy (and sometimes radiation) works before surgery for non-small cell lung cancer. It aims to see if the blood test can detect small amounts of remaining cancer to guide further treatment.

Multi-target immune cell therapy for advanced liver cancer

This trial tests a new type of immune cell therapy (multi-target Hi-TCR-T cells) for people with advanced liver cancer that hasn't responded to earlier treatments. The therapy targets several markers on your cancer cells to try to attack the tumor more effectively.

Advanced HIV study in Zambia for those starting HIV treatment

This study looks at people with advanced HIV disease during their first months on antiretroviral therapy (ART). It aims to understand and improve care for those who start treatment when their immune system is weak.

Probiotics for advanced bladder cancer

This trial tests if taking probiotics can help people with advanced bladder or urinary tract cancer that has spread. It's for those who have already tried immunotherapy. The goal is to see if probiotics can improve treatment outcomes.

Imaging for early heart failure with stiff heart muscle (HFpEF)

This study uses advanced imaging to find early signs of a type of heart failure where the heart pumps well but doesn't relax properly (HFpEF). It may help if you have shortness of breath and a slightly enlarged heart chamber but don't yet have a clear heart failure diagnosis.

Fecal transplant and diet changes for ulcerative colitis

This trial tests if a fecal transplant combined with dietary changes can help control symptoms in people with active ulcerative colitis who haven't responded well to standard treatments or advanced therapies.

Study of PARP1 inhibitor EIK1004 for advanced solid tumors

This trial is testing a new drug (EIK1004) designed to block a protein called PARP1, which helps repair DNA. It is for people with advanced solid tumors, especially those with BRCA or other DNA repair gene mutations. The goal is to see if it can shrink tumors or slow their growth.

Optimizing treatment before surgery for advanced esophageal cancer

This trial tests different combinations of treatments given before surgery for a type of esophageal cancer called squamous cell carcinoma. It aims to find the best approach to shrink the tumor and improve outcomes for patients whose cancer has not spread to distant organs.

Testing SHR-3792 for advanced solid tumors

This trial tests a new drug called SHR-3792 for people with advanced solid tumors that cannot be removed by surgery or have spread. The goal is to see if the drug is safe and how it affects the tumors.

Liver transplant for bile duct cancer after treatment

This trial tests if a liver transplant can help people with a certain type of bile duct cancer (intrahepatic cholangiocarcinoma) that cannot be removed by surgery. Before the transplant, you would receive radiation therapy (SIRT) and chemotherapy to shrink the tumor.

A Study of QLP2117 in Combination With QL2107 in Advanced Solid Tumor Patients

Study of HRS-7058 combined with cancer drugs for advanced solid tumors

This trial tests a new drug, HRS-7058, combined with other anti-cancer drugs for people with advanced solid tumors that cannot be surgically removed. The goal is to see if the combination can shrink tumors or slow their growth.

New insulin pump study for children with new type 1 diabetes

This study tests a new insulin pump system (MiniMed 780G) in children aged 7-17 who were recently diagnosed with type 1 diabetes. It aims to see if this pump helps control blood sugar better and improves quality of life compared to standard insulin shots or older pumps.

Lung Cancer and Aging in Older Adults

This trial looks at aging-related changes in older adults (70+) with early-stage lung cancer who are planning to have surgery. The goal is to better understand how these changes might affect recovery and outcomes, which could help improve care for future patients.

Radiation before surgery for advanced thymoma

This trial tests giving radiation therapy before surgery for a type of thymus gland tumor (thymoma) that has grown into nearby tissues but has not been treated yet. The goal is to see if this approach can make the tumor removable and improve outcomes.

Trial of HRS-6768 for advanced solid tumors

This trial tests a new drug called HRS-6768 for people with advanced solid tumors that have stopped responding to standard treatments or have no good options. It aims to see if the drug is safe and effective.

A trial of BA1301 for advanced solid tumors

This trial tests a new drug, BA1301, in people with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and see if BA1301 can help shrink or control the cancer.

Study of HS-20122 for advanced solid tumors

This trial tests a new drug called HS-20122 in people with advanced solid tumors that have not responded to standard treatments. The goal is to see if it is safe and effective.

Study of AK146D1 for advanced solid tumors

This study tests an experimental drug (AK146D1) for people with advanced solid tumors that are no longer responding to standard treatments. The goal is to see if it is safe and effective.

HS-20108 for advanced solid tumors (phase 1)

This phase 1 study tests an investigational drug called HS-20108 in people with advanced solid tumors. It aims to find a safe dose and see how well the drug works against cancer.