Clinical trials
Advanced or Metastatic Non-small Cell Lung Cancer clinical trials
Below are recruiting advanced or metastatic non-small cell lung cancer clinical trials, each written for real people, not researchers. We’re tracking 5,668 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04959175RecruitingPhase 1/Phase 2
Lower post-transplant drug doses for older or unfit patients
This trial tests whether giving a lower dose of cyclophosphamide after a bone marrow transplant can be safer for older or medically “unfit” patients, while still helping control blood cancers. It is designed for people who can’t tolerate the usual strongest transplant preparation.
Bethesda, MarylandAges 12–85 - NCT04969835RecruitingPhase 1
Safety and early response study of AVA6000 for solid tumors
This Phase 1 study tests AVA6000 in people with certain solid tumor cancers, mainly to check safety and how the body processes the drug. It also looks for early signs of tumor response to see if it might help further in later studies.
New York, New YorkAges 18 years+ - NCT04992559RecruitingPhase 2
Toripalimab after surgery and chemoradiation for head and neck cancer
This trial studies toripalimab to lower the risk of the cancer coming back after surgery and additional chemo-radiation. It may help the immune system “finish the job” after your main treatment, especially if you have higher-risk features.
Guangzhou, GuangdongAges 18–70 - NCT04999904Recruiting
Balance training on uneven treadmill for unstable ankles
This study tests a special balance and movement training program on an uneven treadmill to improve ankle stability. It may help people whose ankles “give way” or keep getting sprained, but it requires specific timing after an ankle sprain and the ability to attend sessions for about 6 weeks.
Oceanside, CaliforniaAges 18–49 - NCT05006482RecruitingPhase 3
Geriatric education and care support for older cancer survivors
This study tests whether a structured health education and “older adult care” approach—done with your oncology team—can improve support for people after cancer. It includes older cancer survivors and a chosen caregiver, using in-person or video visits for follow-up.
Tuscaloosa, AlabamaAges 18 years+ - NCT05049057RecruitingPhase 2
Testing a nerve-blocking shot for recent mild TBI
This Phase 2 study tests a medication that blocks a pain signal (a CGRP receptor antibody) in people who recently had a mild traumatic brain injury (mTBI) and are also dealing with post-traumatic headache (PTH). The goal is to see if it can reduce symptoms and improve recovery after the injury.
Fort Bragg, North CarolinaAges 18–50 - NCT05071144Recruiting
Registry for children getting robotic spine surgery
This trial registry collects information about kids and teens with spine deformities who are scheduled for robotic or navigation-assisted surgery (sometimes using custom rods). It may help doctors improve these advanced techniques over time.
Los Angeles, CaliforniaAges birth–21 years - NCT05074355RecruitingPhase 2
Venetoclax plus azacitidine for advanced MPN without BCR-ABL
This trial tests whether venetoclax together with azacitidine can shrink and control advanced blood cancers caused by myeloproliferative neoplasms (MPN) that do not have the BCR-ABL gene. It may help people whose disease has moved into an accelerated or blast phase when standard options haven’t yet included blast-reducing treatment.
Toronto, OntarioAges 18 years+ - NCT05097625Recruiting
Testing early detection of head and neck cancer relapse
This study aims to find signs of head and neck cancer coming back early, using scans/tests after you’ve had radical treatment. If you’re at higher risk and HPV-negative, this may help doctors catch relapse sooner.
LondonAges 18 years+ - NCT05120596RecruitingPhase 1/Phase 2
Testing an immune-targeting drug by direct injection into tumors
This Phase 1/2 trial tests T3P, a new treatment given directly into reachable solid tumors, to see if it is safe and can help shrink tumors. It is for adults with advanced cancers when no curative treatment is available.
Pamplona, NavarreAges 18–74 - NCT05132504RecruitingPhase 2
Pre-surgery chemotherapy and immunotherapy for operable pancreatic cancer
This Phase 2 trial tests giving chemotherapy plus pembrolizumab (an immunotherapy) before surgery, to shrink or control potentially removable pancreatic cancer. The goal is to improve outcomes while making sure the cancer can still be safely removed by surgery.
Houston, TexasAges 18 years+ - NCT05142982Recruiting
Radiation or watchful waiting after chemo for seminoma
This study compares giving radiation versus observation (no immediate radiation) for men with advanced seminoma whose PET-CT scan shows a leftover mass after first-line chemotherapy. It aims to see which approach controls the disease better while protecting quality of life.
Mumbai, MaharashtraAges 18–80 - NCT05147519Recruiting
Observes HIV and other infections to learn who gets them
This is an observational study that follows people to better understand how HIV and other infections (like sexually transmitted infections) happen and change over time. It may help researchers improve prevention and care, but it is mainly for monitoring rather than testing a new treatment.
Kericho, Kericho CountyAges 14–55 - NCT05150691RecruitingPhase 1/Phase 2
Early study of an HER2 drug in advanced solid tumors
This early-phase trial tests DB-1303 and BNT323 together in people with advanced or metastatic solid cancers that have specific HER2 features. It may be an option when standard treatments have stopped working, aiming to find a safer dose and early signs of effectiveness.
Cerritos, CaliforniaAges 18 years+ - NCT05163951Recruiting
Surgery comparison for advanced angle-closure glaucoma
This trial compares two types of glaucoma surgery—trabeculectomy versus a different procedure that also opens the drainage angle—for people with advanced primary angle-closure glaucoma. It aims to see which surgery controls eye pressure and preserves vision better.
Guangzhou, GuangdongAges 45–80 - NCT05168839RecruitingPhase 3
Using dye scans during surgery to help prevent leakage
This trial tests whether using a special dye and camera during colorectal cancer surgery can help lower the risk of a surgical “leak” where the bowel is joined. If you’re having a planned left-sided colectomy or high rectal resection, the scan may help surgeons see blood flow more clearly.
AmiensAges 18 years+ - NCT05180864Recruiting
Omentum saving surgery versus full removal in stomach cancer
This study compares two ways of doing surgery for gastric (stomach) cancer: saving the omentum versus removing it completely. It may help doctors learn which approach is safer and works better for cancer control and recovery.
MainzAges 18 years+ - NCT05196334Recruiting
Testing pancreatic lab samples to guide future treatments
This study uses small pancreatic cancer samples grown in the lab to understand which treatments may work best for people with pancreatic cancer. It may help researchers better “profile” tumors so standard care can be matched to the most effective options.
Herlev, CopenhagenAges 18 years+ - NCT05201404RecruitingPhase 3
Namodenoson for advanced liver cancer with moderate cirrhosis
This Phase 3 trial studies whether namodenoson can slow or control advanced hepatocellular carcinoma (liver cancer) in people whose cirrhosis is in a specific middle range. It may help if standard treatments have not worked or the cancer has spread and is not expected to be cured.
Dallas, TexasAges 18 years+ - NCT05205954Recruiting
Home hospital care for adults with advanced liver disease
This pilot study tests whether a “home hospital” program can safely care for people with advanced liver disease after they are admitted to the hospital. It may reduce time in the hospital while still treating serious complications like fluid buildup, breathing fluid, or confusion from liver disease.
Boston, MassachusettsAges 18 years+ - NCT05230446Recruiting
Testing full stent treatment for heart artery blockages
This study looks at how well doctors can treat multiple blocked heart arteries using a specific drug-eluting stent, aiming to fully open them. It may help patients whose blockage pattern fits the study, but it does not include certain high-risk or special cases.
Rotterdam, South HollandAges 18–85 - NCT05246475Recruiting
PET-MRI scan study for oxygen levels in head and neck tumors
This study uses a combined PET-MRI scan to measure how much oxygen a head and neck tumor has. It may help doctors understand tumor “oxygen levels,” which can relate to how tumors grow and respond to treatment.
Turku, G102881Ages 18–80 - NCT05251389RecruitingPhase 1/Phase 2
Fecal microbiome transplant after anti-PD-1 melanoma not working
This trial tests whether a fecal microbiome transplant (FMT) can help your body respond better to anti-PD-1 immunotherapy in advanced skin melanoma. It is for people whose melanoma has progressed despite anti-PD-1 treatment.
AmsterdamAges 18 years+ - NCT05254327RecruitingPhase 2
Radiation plus or minus BMX-001 for advanced rectal cancer
This Phase 2 study tests two different ways of giving radiation before surgery for locally advanced rectal cancer, with or without an added study drug called BMX-001. It aims to see whether the shorter/longer radiation plans and BMX-001 improve cancer control and are safe.
Lexington, KentuckyAges 18 years+
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Common questions
- Are there clinical trials for advanced or metastatic non-small cell lung cancer?
- Yes. Clin2 currently lists 5,668 recruiting advanced or metastatic non-small cell lung cancer studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a advanced or metastatic non-small cell lung cancer trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a advanced or metastatic non-small cell lung cancer trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
- Locally Advanced or Metastatic Non-small Cell Lung Cancer
- Metastatic Non-squamous Non Small Cell Lung Cancer
- Advanced Non-squamous Non-small-cell Lung Cancer
- NSCLC (Advanced Non-small Cell Lung Cancer)
- Non Small Cell Lung Cancer Metastatic
- Non Small Cell Lung Cancer
- Non-squamous Non-small Cell Lung Cancer
- Locally Advanced Non-Small Cell Lung Cancer
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.