Clinical trials
Alcohol Use Disorder clinical trials
Below are recruiting alcohol use disorder clinical trials, each written for real people, not researchers. We’re tracking 370 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05219175RecruitingPhase 2
MDMA therapy for PTSD and opioid addiction after childbirth
This Phase 2 study tests whether MDMA-assisted therapy can reduce symptoms of PTSD and help with opioid use disorder in people after childbirth. You must be on a stable, low enough dose of methadone or buprenorphine and be able to follow study rules, including therapy sessions and safety monitoring.
Albuquerque, New MexicoAges 18 years+ - NCT06446479RecruitingPhase 2
THC's effect on alcohol use and brain reward
This study tests whether THC (the active ingredient in cannabis) can change how much alcohol you drink and how your brain responds to rewards. You will have MRI scans and take THC or a placebo, then drink alcohol in a controlled setting.
Aurora, ColoradoAges 21–40 - NCT06580457Recruiting
Personalized smartphone program for Veterans with substance use
This study tests a personalized smartphone program to help Veterans reduce harmful substance use. It uses daily surveys and feedback to support healthier habits.
Minneapolis, MinnesotaAges 18 years+ - NCT07418424Enrolling by invitation
Writing exercise to help college seniors drink less alcohol
This study tests whether a guided writing exercise can help college seniors make healthier decisions about alcohol. You will attend three virtual sessions and share your experiences with drinking.
Houston, TexasAges 18–25 - NCT06794983Recruiting
Support after jail for health and substance use
This study tests a program that helps people leaving jail connect with healthcare and community services. It is for adults with a history of substance use and a chronic health condition who qualify for Wisconsin Medicaid.
Madison, WisconsinAges 18 years+ - NCT07039175RecruitingPhase 3
Helping veterans with chronic disease change smoking or drinking habits
This study tests a program to help veterans with diabetes, heart disease, or related conditions who are thinking about cutting back on smoking or alcohol. The goal is to see if the program can motivate positive changes in these habits.
Buffalo, New YorkAges 18 years+ - NCT05985850RecruitingPhase 2
Can cannabis help with opioid addiction treatment?
This trial tests if adding a specific cannabis product to standard methadone treatment helps people with opioid use disorder. It's for adults over 25 who recently started methadone and have used cannabis before.
Vancouver, British ColumbiaAges 25 years+ - NCT07624227RecruitingPhase 1/Phase 2
Cobenfy Maintenance Effects on Cocaine Use Disorder
This study tests whether a medication called Cobenfy can reduce cocaine's effects in people with cocaine use disorder. Researchers will monitor your health and test how the medication impacts your response to cocaine.
Lexington, KentuckyAges 18–60 - NCT05649982Recruiting
Digital guidance program for risky alcohol use
This study tests a Swedish digital tool that gives guidance to help people reduce problematic drinking. You may be able to join if your alcohol screening results suggest risky use and you can use the internet and digital content.
StockholmAges 18 years+ - NCT06569394RecruitingPhase 2
Testing CBD in young adults who use cannabis heavily
This study tests whether cannabidiol (CBD) can help young adults who use cannabis heavily but aren't looking to quit. You'll take a CBD pill and see if it changes your cannabis use or related symptoms.
Aurora, ColoradoAges 18–25 - NCT05008146RecruitingEarly Phase 1
Brain imaging study for cocaine use disorder interactions
This early-phase study uses brain imaging to understand how cocaine use disorder affects brain function. It may help researchers learn more about brain pathways involved in craving and treatment targets.
Pittsburgh, PennsylvaniaAges 18–55 - NCT05703685RecruitingPhase 1
Imaging brain inflammation target in depression with PET
This Phase 1 study uses a PET brain scan tracer to see how a specific brain target (PDE4B) is involved in major depressive disorder (MDD). It’s mainly testing whether the imaging approach works and what it shows in people with depression who meet specific safety and medication rules.
Bethesda, MarylandAges 18–70 - NCT07644052RecruitingPhase 3
A medication to ease cannabis withdrawal symptoms
This study tests whether a medication called PP-01 can help reduce cravings and uncomfortable symptoms when people stop using cannabis. If you're a heavy cannabis user who wants to quit and experiences withdrawal symptoms, this trial may help you manage the difficult transition.
Little Rock, ArkansasAges 18–55 - NCT06575751RecruitingPhase 2
Study of cannabidiol and cannabis concentrate users
This study looks at how cannabidiol (a compound in cannabis) affects people who regularly use strong cannabis concentrates like wax, shatter, or oil. It may help understand if using CBD can change how cannabis affects the body or help with cannabis use disorder.
Aurora, ColoradoAges 25–60 - NCT06115252Recruiting
Brain scan study for young adults responding to programs
This study uses brain scans and follow-up surveys to understand how young adults respond to programs. It may help if you are a right-handed young adult without a history of brain injury or certain mental health conditions.
Dallas, TexasAges 18–19 - NCT07740395Recruiting
Support app for people in recovery and their loved ones
This study tests a support app (KulaMind-Recovery) that helps people in recovery stay connected with a loved one. You and someone important to you would both use the app to see if it helps your recovery journey.
Providence, Rhode IslandAges 18 years+ - NCT07064564RecruitingPhase 1
Study comparing naltrexone implants with monthly injection in healthy volunteers
This trial compares two forms of naltrexone (a medication used for alcohol and opioid dependence) in healthy volunteers. It tests how well the body processes and tolerates a low or high-dose implant versus the standard monthly injection.
Millcreek, UtahAges 18–65 - NCT04458545RecruitingPhase 1/Phase 2
Opioid vaccine study for adults with heroin or fentanyl use
This trial tests a vaccine made from parts designed to help the body respond to opioids (heroin or fentanyl). It is mainly for adults with moderate-to-severe opioid use disorder who are using opioids that match the study dosing needs and who are willing to do frequent visits over about a year.
Eatontown, New JerseyAges 18–59 - NCT04893525RecruitingPhase 2/Phase 3
Buprenorphine-naloxone microdosing versus standard dosing after ED discharge
This study compares a smaller “microdose” starting method versus the usual starting dose of buprenorphine/naloxone for people with opioid use disorder when they are discharged from the emergency department. It may help find a safer, easier way to start treatment right after an ED visit and avoid problems caused by starting too early.
Calgary, AlbertaAges 18 years+ - NCT05630781Recruiting
Orexin's role in the neurobiology of addiction
This study looks at how a brain chemical called orexin affects addiction. Researchers will give a medication that blocks orexin to see if it helps reduce cravings or use. It might help people who smoke or vape regularly.
Baltimore, MarylandAges 18–60 - NCT05027919RecruitingPhase 2
Testing ways to predict opioid withdrawal during a taper
This Phase 2 study looks at what opioid withdrawal looks like in the body and whether they can measure it in a meaningful way. You may join if you have an opioid use disorder, can show physical dependence, and are interested in tapering (gradually reducing) opioids under study care.
Baltimore, MarylandAges 18–65 - NCT05033028RecruitingPhase 3
Using a smartphone to support opioid addiction recovery
This Phase 3 study tests whether using smartphones can help people with opioid-use disorder stick with treatment and recover more successfully. It focuses on people starting or already in treatment using methadone or buprenorphine, with support delivered through the study app or messages.
Piscataway, New JerseyAges 18–85 - NCT05142267Recruiting
Study stress and opioid-risk factors in chronic low back pain
This study looks at how stress and the body’s natural opioid/cannabinoid systems may relate to risk of opioid misuse. It tests people with long-lasting low back pain to see what biological or psychological factors might increase or lower that risk.
Nashville, TennesseeAges 18 years+ - NCT05587361RecruitingPhase 4
Nicotine cue study using propranolol to study craving
This study tests whether a beta-blocking medicine (propranolol) and nicotine patches change how strongly your brain responds to smoking cues. It may help researchers understand what drives cigarette cravings and how to reduce them.
Tulsa, OklahomaAges 21–60
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Common questions
- Are there clinical trials for alcohol use disorder?
- Yes. Clin2 currently lists 370 recruiting alcohol use disorder studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a alcohol use disorder trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a alcohol use disorder trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.