Clinical trials
Amputation clinical trials
Below are recruiting amputation clinical trials, each written for real people, not researchers. We’re tracking 140 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05473065Recruiting
Test-drive plan for a safer prosthetic foot
This study tests a “test-drive” approach to help improve walking stability using different prosthetic feet. You may be asked to try study prosthetic feet during walking tests to see what helps your balance and comfort.
Minneapolis, MinnesotaAges 18–89 - NCT04934839Recruiting
Gait study comparing prosthetic walking types in adults
This study compares how people walk using an osseointegrated prosthesis (a prosthesis connected to the bone) versus a traditional socket prosthesis. It may help researchers understand which option works better for walking balance, comfort, and function.
Milan, MIAges 18 years+ - NCT04030650Recruiting
Study of walking expectations on slopes and stairs after limb amputation
This study looks at how people with a leg amputation think about and perform walking on stairs and up/down slopes. It may help researchers understand what supports safer, more confident mobility.
DijonAges 18 years+ - NCT03260400Recruiting
Temporary implanted electrodes to improve prosthetic arm control
This study tests placing temporary electrodes after a nerve surgery (regenerative peripheral nerve surgery) to help your prosthetic arm pick up better control signals. It may help people with an upper-limb amputation use a prosthesis more accurately while the electrodes are in place.
Ann Arbor, MichiganAges 22–75 - NCT07263945RecruitingPhase 1
Prosthetic Foot Stiffness and Walking in Below-Knee Amputation
This study tests how different prosthetic foot stiffness levels affect walking, balance, and comfort in people with a below-knee amputation who use either a bone-anchored implant or a traditional socket. Participating may help match the right foot to your needs and improve your daily mobility.
Aurora, ColoradoAges 18 years+ - NCT06780943Recruiting
Study on how people with leg amputations adapt their walking
This study looks at how people with a leg amputation change the way they walk to make up for lost function. It may help improve rehabilitation and prosthetic care.
NîmesAges 18–80 - NCT07222085Recruiting
Long-term test of a new myoelectric control strategy
This trial tests a new way to control a powered prosthetic arm called Glide control. Researchers want to see if it stays reliable over time for people who have lost part of their arm below or above the elbow.
Annapolis, MarylandAges 18 years+ - NCT07592325Recruiting
Testing a New Flexible Prosthetic Socket for Below-Knee Amputees
This trial compares a new flexible prosthetic socket design to the rigid socket you currently wear. The goal is to see if the new socket is more comfortable, easier to put on, and improves how well your prosthetic leg works for daily activities.
ClamartAges 18 years+ - NCT07075042Recruiting
Comparing two myoelectric arm control methods
This study compares two ways of controlling a muscle-powered (myoelectric) prosthetic arm to see which is easier on your attention and works better for daily tasks. It might help you find a more comfortable and effective way to use your prosthetic arm.
Austin, TexasAges 18 years+ - NCT07666204Recruiting
Improving prosthetic control after arm loss
This trial tests a new training approach to help people who have lost or were born without an arm below the elbow or higher. The training uses sensory and movement exercises to improve how you control a prosthetic device.
NancyAges 18 years+ - NCT06218238Recruiting
Testing the Ossur Power Knee for above-knee amputees
This study tests a new bionic knee called the Ossur Power Knee for people with an above-knee amputation. It looks at how well the knee helps with walking and balance, which may lead to better mobility.
Chicago, IllinoisAges 45–75 - NCT07448350Recruiting
TENS therapy for better sensation after leg amputation
This study tests if a gentle electrical stimulation method called TENS can help people who have lost a leg below or above the knee feel more natural sensations in their missing limb and reduce phantom limb pain.
Rome, RomeAges 18–80 - NCT06638723Recruiting
Better walking after leg amputation
This study tests a new training program to help improve walking and balance for people with one leg amputation. You'll visit UNLV six times for practice sessions.
Las Vegas, NevadaAges 18 years+ - NCT07384689Recruiting
Study of leg tissue in non-traumatic amputation patients
This study looks at the tissue environment in the legs of patients who need amputation due to non-traumatic causes, like poor blood flow or infection. Understanding the tissue better might help improve healing for future patients.
Aarhus NAges 18 years+ - NCT07347561Recruiting
Comparing myoelectric and bionic prosthetic hands
This study compares two types of prosthetic hands: a myoelectric hand (controlled by muscle signals) and a bionic hand (with more advanced features). The goal is to see which one works better for people who already use a prosthetic arm with a semi-electronic elbow.
Ankara, KeçiörenAges 18–65 - NCT07265154Recruiting
Gait training with AI for above-knee amputees
This trial tests a new way to help people with above-knee amputations improve how they walk, using artificial intelligence to guide their gait training. It may help you walk more naturally and safely.
Banhā, BenhaAges 16–50 - NCT05830630Recruiting
Methylene blue given during leg amputation surgery
This trial studies whether infusing methylene blue during above- or below-knee leg amputation can improve outcomes for people with poor blood flow to the legs. It targets patients having surgery under general anesthesia, while excluding those with certain allergies or blood clotting problems.
Tanta, Gharbia GovernorateAges 18 years+ - NCT07266077Recruiting
A study of a slope-adapting prosthetic foot for Veterans
This study tests a special prosthetic foot that adapts to slopes (like hills or ramps) to help Veterans with below-knee amputations walk more easily. You would need to visit the Minneapolis VA and use a special foot for a while.
Minneapolis, MinnesotaAges 18–89 - NCT05929508Recruiting
Rebuilding leg strength after above-knee amputation
This study tests a new approach to improve walking ability and leg function after an above-knee (transfemoral) amputation. It may help by targeting muscle loss and supporting safer, stronger mobility over time.
Chicago, IllinoisAges 18 years+ - NCT07214493Recruiting
Study of a prosthetic foot with adjustable heel height
This trial tests a prosthetic foot that lets you adjust the heel height so you can comfortably walk in different shoes or barefoot. It is for people with a leg amputation who already use a certain type of prosthetic foot and want more flexibility in their footwear.
ConcarneauAges 18 years+ - NCT07613502Recruiting
Bio Leg: Advancing Mobility (BAM)
This study tests a new prosthetic leg designed to help people with above-knee amputations walk better. It may be a good fit if you already use a C-leg and can walk with a single point cane.
Jacksonville, FloridaAges 40–70 - NCT06921707Recruiting
WounDx test for healing decisions in large wounds
This trial tests a new tool called WounDx that helps doctors decide the best way to treat large wounds on arms, legs, or buttocks. It may help your wound heal better by guiding your care.
Birmingham, AlabamaAges 18–65 - NCT03594344Recruiting
Extra hyperbaric oxygen after leg amputation wounds heal
This study tests whether giving extra treatments with hyperbaric (pressure) oxygen after a leg amputation can improve healing or recovery. It’s meant for people whose amputation happened due to long-lasting infection or poor blood flow and who can attend follow-up visits.
OsloAges 18–90 - NCT03995238Recruiting
Gait training for veterans with leg amputations
This study tests a walking rehabilitation plan to improve how you walk after a lower-leg amputation. It may help if your walking steps are uneven and you have diabetes and/or circulation problems in your legs.
Aurora, ColoradoAges 40–89
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Common questions
- Are there clinical trials for amputation?
- Yes. Clin2 currently lists 140 recruiting amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.