Clinical trials
Amputation clinical trials
Below are recruiting amputation clinical trials, each written for real people, not researchers. We’re tracking 141 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT03995238Recruiting
Gait training for veterans with leg amputations
This study tests a walking rehabilitation plan to improve how you walk after a lower-leg amputation. It may help if your walking steps are uneven and you have diabetes and/or circulation problems in your legs.
Aurora, ColoradoAges 40–89 - NCT04220047Recruiting
Surgery changes for preventing irregular heart rhythms during bypass
This trial studies whether removing a small heart pouch area and a specific ligament during off-pump heart bypass surgery improves outcomes. It is meant for people having their first off-pump coronary bypass, without a history of atrial fibrillation.
BeijingAges 18–80 - NCT07640516Recruiting
Pain Relief Comparison for Amputation Surgery in High-Risk Patients
This study compares two medications (dexmedetomidine and fentanyl) mixed with a numbing agent to see which works better for blocking pain during above-knee amputation surgery in patients with serious heart or lung disease. Both drugs are already used in anesthesia, and this trial tests which combination is safest and most effective for you.
CairoAges 18 years+ - NCT05124652Recruiting
Testing a prosthetic socket that adjusts automatically
This trial is testing a prosthetic socket that can automatically adjust to help fit better and feel more comfortable. It may help people with below-knee (transtibial) amputations who currently struggle with socket fit or comfort.
Seattle, WashingtonAges 18 years+ - NCT06167330Recruiting
Titan trial: Reducing phantom limb pain
This trial tests a new method to reduce phantom limb pain (pain felt in a missing limb) using gentle electrical stimulation and simple mental exercises. It is for people with one-sided amputations who have had phantom limb pain for at least three months and still have pain episodes now.
Randwick, New South WalesAges 18 years+ - NCT06552910Recruiting
Anesthesia in diabetic foot amputation
This study looks at different types of anesthesia used during foot amputation surgery for people with diabetic foot. It aims to find which method works best for your comfort and safety during the procedure.
Etimesgut, AnkaraAges 18 years+ - NCT06719245Recruiting
Preventing post-amputation pain with targeted nerve surgery
This trial tests a surgical procedure called targeted muscle reinnervation (TMR) to prevent pain after a leg amputation. The goal is to see if rerouting nerves during amputation can reduce phantom limb pain or stump pain.
Amsterdam, North HollandAges 18–75 - NCT06886295Recruiting
New ways to control an advanced prosthetic hand
This study is testing new, more natural ways to control an advanced prosthetic hand for people with below-elbow amputations. It may help you move the prosthetic more easily and intuitively.
Bologna, BoAges 18–65 - NCT07044323Recruiting
Virtual reality for phantom limb pain after leg amputation
This study tests whether using virtual reality at home for 30 minutes a day can reduce phantom limb pain after a leg amputation. It aims to improve how your brain handles pain signals.
Philadelphia, PennsylvaniaAges 18–100 - NCT07276867Recruiting
Spinal Add-On Medicine for Leg Amputation from Sarcoma
This trial tests adding two medicines (dexmedetomidine and fentanyl) versus fentanyl alone to the standard spinal anesthetic for above-knee amputation surgery for lower limb sarcoma. The goal is to see if the combination provides better pain control during and after surgery.
CairoAges 18–60 - NCT07325708Recruiting
Testing a new implant to control a bionic hand
This trial tests a small implant that reads muscle signals to help you control a prosthetic hand more naturally. You may qualify if you have a missing hand or arm below the elbow and currently use or could use a myoelectric (muscle-signal) prosthetic.
Malvern, VictoriaAges 18 years+ - NCT07677969Recruiting
Arm loss, balance, pain, and daily life study
This study looks at how the percentage of arm loss affects balance, neck and back pain, daily activities, and reaction time in people with one arm amputated who use a myoelectric or bionic hand. It may help understand how to improve care and rehabilitation.
AnkaraAges 18–65 - NCT07393139Recruiting
Pain after arm or leg amputation
This study looks at pain in the days right after a limb amputation surgery. It aims to better understand and manage early pain, which could help improve recovery.
BolognaAges 18 years+ - NCT07401966Recruiting
Amputation in childhood and nerve pain study
This study looks at nerve pain in children and teens who had an amputation before a certain age. It aims to understand how common and how severe this pain is after amputation, and uses simple questionnaires to find out.
Saint-MauriceAges 5–18 - NCT07420192Recruiting
A study on nerve surgery for pain after leg amputation
This trial tests a surgery called RPNI to treat painful nerve growths (neuromas) in people who have lost a leg. The goal is to reduce severe pain and improve the ability to use a prosthetic limb.
Ankara, AnkaraAges 18–70 - NCT06458426Enrolling by invitation
Body temperature control study for below-knee amputees
This study looks at how your body adjusts its temperature while walking if you have a leg amputation below the knee. It may help researchers find better ways to keep you comfortable and safe during activity.
Salt Lake City, UtahAges 19 years+ - NCT05505513Recruiting
Test micro-electrode nerve implants for hand signal feedback
This study looks at whether tiny implanted sensors in a nerve can record brain/nerve signals and use them to provide feedback for people with a transradial arm amputation. If it works, it could help improve control or awareness with a prosthetic hand or related devices.
Salt Lake City, UtahAges 18–65 - NCT05376332Enrolling by invitation
Testing a new arm prosthesis control and training approach
This study is testing different ways to control an arm prosthesis for people missing a hand or lower arm (transradial amputation). It may help compare how well people can use a myoelectric (muscle-signal) prosthesis using either direct control or pattern recognition.
Fairfax, VirginiaAges 18–65 - NCT06539936Recruiting
Testing a new control method for a bionic hand
This trial tests a new way to control a bionic hand for people who have a below-elbow amputation. The goal is to make the hand easier and more natural to use.
Redondo Beach, CaliforniaAges 18 years+ - NCT06138977Recruiting
Testing a smart bionic leg for different walking activities
This study tests a new type of bionic leg that can adjust to different walking speeds and activities. You may be able to join if you are a healthy adult or an adult with a leg amputation who can walk well.
Ann Arbor, MichiganAges 18–65 - NCT06853938Recruiting
Optimizing control of a prosthetic arm after osseointegration surgery
This study looks at a new way to control a prosthetic arm after you have had osseointegration surgery (where a metal implant is placed in your bone to attach the arm). It will help find the best settings for the muscle signals that control the arm.
Edmonton, AlbertaAges 18–65 - NCT05964855Enrolling by invitation
Test of different prosthetic foot and ankle mechanisms
This study compares different prosthetic foot and ankle designs for people who have an above-ankle (transtibial) amputation. It may help find which designs work best for your mobility level.
Cambridge, MassachusettsAges 18–65 - NCT05779852Recruiting
Hypnosis to ease new foot amputation wound pain
This trial tests whether auto-hypnosis (a self-guided calming technique) can reduce pain after a toe or multiple toes are removed. It is for adults who are newly after an amputation and have moderate pain soon after the first dressing.
RennesAges 18 years+ - NCT05831696Recruiting
Compare walking effort with two types of prosthetic knees
This trial studies how much energy it takes to walk when using passive versus powered prosthetic knees. It may help people understand which knee type could make walking feel easier depending on their needs.
Loma Linda, CaliforniaAges 18–75
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Common questions
- Are there clinical trials for amputation?
- Yes. Clin2 currently lists 141 recruiting amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.