Clinical trials
Amputation clinical trials
Below are recruiting amputation clinical trials, each written for real people, not researchers. We’re tracking 145 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07222085Recruiting
Long-term test of a new myoelectric control strategy
This trial tests a new way to control a powered prosthetic arm called Glide control. Researchers want to see if it stays reliable over time for people who have lost part of their arm below or above the elbow.
Annapolis, MarylandAges 18 years+ - NCT07214493Recruiting
Study of a prosthetic foot with adjustable heel height
This trial tests a prosthetic foot that lets you adjust the heel height so you can comfortably walk in different shoes or barefoot. It is for people with a leg amputation who already use a certain type of prosthetic foot and want more flexibility in their footwear.
ConcarneauAges 18 years+ - NCT07094074Recruiting
Walking and balance study for leg amputees
This study looks at how people who have lost a leg walk, balance, and move with an artificial limb (prosthesis). Participating helps researchers understand how to improve prosthetic devices and rehabilitation.
DijonAges 18 years+ - NCT07076602Recruiting
Walking and energy use in children with leg amputations
This study looks at how children with a leg amputation walk and how much energy they use when walking. It aims to better understand gait and energy use to improve care and prosthetic fitting.
BerckAges 7–17 - NCT07075042Recruiting
Comparing two myoelectric arm control methods
This study compares two ways of controlling a muscle-powered (myoelectric) prosthetic arm to see which is easier on your attention and works better for daily tasks. It might help you find a more comfortable and effective way to use your prosthetic arm.
Austin, TexasAges 18 years+ - NCT07044323Recruiting
Virtual reality for phantom limb pain after leg amputation
This study tests whether using virtual reality at home for 30 minutes a day can reduce phantom limb pain after a leg amputation. It aims to improve how your brain handles pain signals.
Philadelphia, PennsylvaniaAges 18–100 - NCT06921707Recruiting
WounDx test for healing decisions in large wounds
This trial tests a new tool called WounDx that helps doctors decide the best way to treat large wounds on arms, legs, or buttocks. It may help your wound heal better by guiding your care.
Birmingham, AlabamaAges 18–65 - NCT06840262Recruiting
Nerve surgery for pain after cancer amputation
This study tests two surgical techniques—target muscle re-innervation and regenerative peripheral nerve interfaces—alone or together, to help reduce pain felt in the remaining limb or the missing limb (phantom pain) after amputation for cancer. The goal is to find the best way to manage pain and improve quality of life.
Houston, TexasAges 18 years+ - NCT06780943Recruiting
Study on how people with leg amputations adapt their walking
This study looks at how people with a leg amputation change the way they walk to make up for lost function. It may help improve rehabilitation and prosthetic care.
NîmesAges 18–80 - NCT06719245Recruiting
Preventing post-amputation pain with targeted nerve surgery
This trial tests a surgical procedure called targeted muscle reinnervation (TMR) to prevent pain after a leg amputation. The goal is to see if rerouting nerves during amputation can reduce phantom limb pain or stump pain.
Amsterdam, North HollandAges 18–75 - NCT06501092Recruiting
Study of the Point Mini prosthetic hand for children
This study tests a new type of prosthetic hand device called the Point Mini. It is designed for children and teens who have partial hand differences, and aims to see how well it works in everyday use at home.
Lafayette, ColoradoAges 3–17 - NCT06458426Enrolling by invitation
Body temperature control study for below-knee amputees
This study looks at how your body adjusts its temperature while walking if you have a leg amputation below the knee. It may help researchers find better ways to keep you comfortable and safe during activity.
Salt Lake City, UtahAges 19 years+ - NCT06415955Recruiting
Walking limits study for people with leg amputation
This study looks at what makes walking harder for people with a lower limb amputation. Participants will walk on a treadmill to help researchers understand these limits and improve rehabilitation.
Nîmes, GardAges 18–80 - NCT06218238Recruiting
Testing the power knee for above-knee amputees
This study tests a powered knee called the Ossur Power Knee to see how it affects walking for people who have had an above-the-knee amputation. It might help you walk more smoothly and with less effort.
Chicago, IllinoisAges 45–75 - NCT05929508Recruiting
Rebuilding leg strength after above-knee amputation
This study tests a new approach to improve walking ability and leg function after an above-knee (transfemoral) amputation. It may help by targeting muscle loss and supporting safer, stronger mobility over time.
Chicago, IllinoisAges 18 years+ - NCT05830630Recruiting
Methylene blue given during leg amputation surgery
This trial studies whether infusing methylene blue during above- or below-knee leg amputation can improve outcomes for people with poor blood flow to the legs. It targets patients having surgery under general anesthesia, while excluding those with certain allergies or blood clotting problems.
Tanta, Gharbia GovernorateAges 18 years+ - NCT05287646Recruiting
Track how your residual limb moves while walking with a prosthesis
This study uses a special X-ray and markers to measure how your leg and skin move inside your prosthetic socket while you walk. It may help researchers better understand fit and comfort for people with transtibial (below-knee) amputations.
New York, New YorkAges 18 years+ - NCT05124652Recruiting
Testing a prosthetic socket that adjusts automatically
This trial is testing a prosthetic socket that can automatically adjust to help fit better and feel more comfortable. It may help people with below-knee (transtibial) amputations who currently struggle with socket fit or comfort.
Seattle, WashingtonAges 18 years+ - NCT04030650Recruiting
Study of walking expectations on slopes and stairs after limb amputation
This study looks at how people with a leg amputation think about and perform walking on stairs and up/down slopes. It may help researchers understand what supports safer, more confident mobility.
DijonAges 18 years+ - NCT03995238Recruiting
Gait training for veterans with leg amputations
This study tests a walking rehabilitation plan to improve how you walk after a lower-leg amputation. It may help if your walking steps are uneven and you have diabetes and/or circulation problems in your legs.
Aurora, ColoradoAges 40–89 - NCT03260400Recruiting
Muscle and nerve implants to improve bionic arm control
This study tests a new approach that uses small nerve and muscle grafts along with temporary electrodes to help people with an above-wrist arm amputation get better control of a bionic arm. If it works, it could make prosthetics feel more natural and easier to use.
Ann Arbor, MichiganAges 22–75 - NCT07875075Recruiting
Core muscle and balance study for lower limb amputees
This study looks at how core muscle function and balance work in people with a single leg amputation who use a prosthesis. It aims to understand how these factors affect daily activities and may help improve rehabilitation.
Balçova, İzmirAges 20–60 - NCT02797457Recruiting
Evaluating outcomes of donated hand and forearm transplants
This trial looks at whether donated (allograft) hand and forearm transplants are worth it compared with artificial devices, including cost and real-world results. It is meant for adults with amputations of both forearms who may be medically and psychologically able to receive the transplant.
BerckAges 18–60 - NCT06214026Recruiting
Study of a new prosthetic foot for better walking
This study tests a new type of prosthetic foot designed to help people walk more naturally. If you use a prosthetic foot and can walk short distances, this trial may help you move better.
Tampa, FloridaAges 16 years+
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Common questions
- Are there clinical trials for amputation?
- Yes. Clin2 currently lists 145 recruiting amputation studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a amputation trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a amputation trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.