Clinical trials · Pennsylvania
Amyotrophic Lateral Sclerosis clinical trials in Pennsylvania
We’re tracking 16 recruiting amyotrophic lateral sclerosis studies with a site in Pennsylvania — including Phase 1, Phase 1/Phase 2, Phase 2, Phase 2/Phase 3 and Phase 3 studies, each written for real people, not researchers.
Recruiting studies in Pennsylvania
- NCT04363684Recruiting
Study of frontotemporal dementia and related syndromes over time
This study follows people with frontotemporal dementia (FTLD) and related conditions, and collects health and (for some people) body fluid information, to understand how these illnesses change over time. It may help researchers track disease signs and find better ways to measure progression.
Philadelphia, PennsylvaniaAges 18 years+ - NCT07023835RecruitingPhase 2
Testing usnoflast for ALS
This trial tests an experimental oral medication called usnoflast for people with ALS. It aims to see if the drug can slow the disease's progression.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT07071935RecruitingPhase 2
Early ventilation study for newly diagnosed ALS
This trial tests whether starting non-invasive ventilation (breathing support) early in ALS helps people breathe easier and live better. If you've been diagnosed with ALS in the last 6 months and haven't used a breathing machine before, you may qualify.
Hershey, PennsylvaniaAges 18 years+ - NCT07290062RecruitingPhase 1
Gene therapy injection for ALS safety study
This trial tests a single injection of a gene therapy called INS1202 into the spinal fluid. It is for people with ALS, including those with a specific genetic form (SOD1 mutation). The goal is to see if it is safe and how it affects the body.
Philadelphia, PennsylvaniaAges 18–79 - NCT07543367Recruiting
Brain implant to restore arm movement in ALS
This study tests a surgically implanted brain-computer interface (BCI)—a device that reads signals directly from your brain to help control a computer cursor or robotic arm. It's designed for people with ALS whose arms are paralyzed and who haven't responded to standard treatments.
Pittsburgh, PennsylvaniaAges 22 years+ - NCT07161999RecruitingPhase 2/Phase 3
COYA 302 treatment for ALS
This study tests an experimental treatment called COYA 302 for ALS. It aims to see if it can slow down the worsening of muscle weakness and improve daily function. It might be an option for people in the earlier stages of ALS.
Philadelphia, PennsylvaniaAges 18–80 - NCT06578195Recruiting
Assess all ALS study
This study follows people with ALS and healthy volunteers over time to understand the disease better. You can join from home using a smartphone or computer.
Hershey, PennsylvaniaAges 18 years+ - NCT07322003RecruitingPhase 3
Pridopidine for ALS: Phase 3 trial testing safety and effectiveness
This trial is testing if an oral medication called pridopidine can slow the progression of ALS. It is for people recently diagnosed with ALS who have mild to moderate breathing function and meet specific risk scores.
Philadelphia, PennsylvaniaAges 18–80 - NCT07703462Enrolling by invitationPhase 1/Phase 2
Personalized therapy for TARDBP ALS
This trial offers a custom-made treatment for people with ALS caused by a TARDBP gene mutation. It uses a personalized medicine approach to target the specific genetic cause of the disease.
Philadelphia, PennsylvaniaAges Any age - NCT04715399Recruiting
Research study collecting data for neurodegenerative diseases
This study collects health information from people with neurodegenerative diseases, some family members, and healthy controls to help researchers better understand these conditions. It may help future diagnosis and research, and participation may include noninvasive checks and other procedures depending on your situation.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06266403Recruiting
Studying how people with ALS communicate in conversations
This study looks at how people with ALS and their conversation partners talk with each other. It aims to understand changes in speech and find better ways to support communication.
University Park, PennsylvaniaAges 18–90 - NCT06581861Recruiting
Family study to prevent ALS and FTD
This study is for adults who have a strong family history of ALS or FTD (like a parent or sibling with the disease) to help researchers understand how to prevent these conditions. It involves following you for about a year to track your health.
Hershey, PennsylvaniaAges 18 years+ - NCT06665165RecruitingPhase 1
Study of AMX0114 for people with ALS
This study tests an experimental drug called AMX0114 for people recently diagnosed with ALS. It is an early-phase trial to see if the drug is safe and how it affects the body.
Philadelphia, PennsylvaniaAges 18 years+ - NCT06819124Recruiting
Study on interactions between people with ALS and their caregivers
This study looks at how people with ALS and their caregivers talk and interact with each other. It may help researchers understand communication challenges and improve support for both.
University Park, PennsylvaniaAges 18–90 - NCT06828523Recruiting
Interactive tasks and how we hear them
This study tests how listening to speech during interactive tasks affects what you hear. It may help us understand how people communicate in everyday situations.
University Park, PennsylvaniaAges 18–65 - NCT07287397RecruitingPhase 1/Phase 2
Testing VTx-002 for safety in ALS patients
This trial tests a new drug called VTx-002 to see if it is safe and tolerable for people with ALS. You may be able to join if you have had symptoms for less than 18 months and have a caregiver who can help.
Philadelphia, PennsylvaniaAges 18 years+
Amyotrophic Lateral Sclerosis trials by city in Pennsylvania
Where these studies are running in Pennsylvania
Institutions with a site for the recruiting amyotrophic lateral sclerosis studies listed above.
- Temple University Hospital · 4 studies
- University of Pennsylvania · 4 studies
- The Pennsylvania State University · 3 studies
- Penn State Health · 2 studies
- Thomas Jefferson University Hospital · 2 studies
- Fox Chase Cancer Center
- Penn State Hershey
- Pennsylvania Hospital
What taking part in a amyotrophic lateral sclerosis study involves
A screening visit first
Before anything else, the study team checks whether you fit — usually a visit with some tests. You can stop at any point, and screening is typically free.
Care at a nearby site
Study visits happen at a clinic or hospital taking part. Many studies cover the cost of the study treatment and related visits, and some reimburse travel.
You stay in control
Taking part is voluntary and you can leave a study at any time, for any reason, without affecting your regular care.
The team decides eligibility
Our fit check is a helpful first read, not a decision. The study team makes the final call after reviewing your health history.
Amyotrophic Lateral Sclerosis trials in other states
Common questions
- Are there amyotrophic lateral sclerosis clinical trials in Pennsylvania?
- Yes. We're currently tracking 16 recruiting amyotrophic lateral sclerosis studies with a site in Pennsylvania, each rewritten in plain language so you can see what it's testing and who it's for.
- How do I find out if I qualify for a amyotrophic lateral sclerosis study in Pennsylvania?
- Each study lists its eligibility rules — age, diagnosis, prior treatments. On every trial page we explain these in plain language and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Do I have to live in Pennsylvania to take part?
- Not necessarily. These studies have a site in Pennsylvania, but eligibility is about your health, not your address — some people travel to take part, and a few studies reimburse travel. The study team can tell you what's required.
- Does it cost anything to join a amyotrophic lateral sclerosis trial?
- Using Clin2 is always free. Many trials cover the study treatment and related visits; some reimburse travel. The study team explains exactly what's covered before you decide.
Not the right time?
New amyotrophic lateral sclerosis studies open in Pennsylvania regularly. Set up a health profile and we’ll quietly watch for studies that fit you and email you when one opens.
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.