Clinical trials
ARDS (Moderate or Severe) clinical trials
Below are recruiting ards (moderate or severe) clinical trials, each written for real people, not researchers. We’re tracking 1,503 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT04763447RecruitingPhase 4
Short omalizumab treatment for severe allergic asthma
This trial tests whether stopping omalizumab for a short time (or using it differently) can be safe for adults with severe allergic asthma who are doing well. It may help some people avoid long-term injections, but only if asthma remains well controlled.
Paris, Île-de-France RegionAges 18 years+ - NCT04774536RecruitingPhase 1/Phase 2
CRISPR gene-edited bone marrow transplant for severe sickle cell
This Phase 1/2 study tests a CRISPR-edited bone marrow (stem cell) transplant to treat severe sickle cell disease. It aims to reduce dangerous sickle-related complications by changing the patient’s stem cells before transplant.
Los Angeles, CaliforniaAges 12–35 - NCT04775108Recruiting
Testing a new heart procedure for severe leaking mitral valve
This trial studies a new transcatheter (through the heart without open surgery) mitral valve treatment for people with severe mitral valve leaking who are too high-risk for standard surgery. It may help reduce valve leakage and improve symptoms, but it’s an early “first-in-human” device study.
InnsbruckAges 60 years+ - NCT04786262RecruitingPhase 3
Study of VX-880 for long-standing type 1 diabetes
This Phase 3 trial tests how safe, tolerable, and effective VX-880 is for people with type 1 diabetes who have had it for many years. It may help reduce problems related to blood sugar swings, especially severe low blood sugar episodes.
Duarte, CaliforniaAges 18–65 - NCT04796844Recruiting
Asthma real-world study for adults in other health studies
This study follows adults with asthma in real life to better understand asthma care and outcomes. You may be invited if you already joined another asthma-related or health-related observational study and don’t have certain major lung or health conditions.
GenovaAges 18–99 - NCT04846712Recruiting
Ultrasound to check how severe a new ankle sprain is
This trial studies whether an ultrasound scan can help doctors judge how severe a first-time ankle sprain is. It may help guide treatment and follow-up for people whose sprain affects work or sports.
Saint-EtienneAges 18–60 - NCT04850456Recruiting
Gamma globulin treatment for critically ill children with inflammation surge
This trial studies whether giving “human gamma globulin” can improve outcomes in very sick children in the ICU who have a severe infection causing an extreme inflammation reaction (“inflammatory storm”). If you’re in the hospital ICU with this complication, the study may offer a targeted treatment strategy and careful monitoring.
Shanghai, Shanghai MunicipalityAges 4 weeks–18 years - NCT04860375Recruiting
Program for severe COPD after a hospital breathing flare-up
This trial studies a coordinated (multidisciplinary) care program for people with severe COPD who were recently hospitalized for worsening breathing symptoms. It may help reduce future flare-ups and improve day-to-day breathing by coordinating multiple types of care in a COPD center.
Gothenburg, VGRAges 40–100 - NCT04864145Recruiting
Valve procedure trial for severe leaking aortic valve
This trial studies a less invasive heart valve procedure that places a new valve through a catheter, to treat severe leakage of the aortic valve. It may help people who have symptoms or heart enlargement and who are at higher risk for open-heart surgery.
Nanjing, JiangsuAges 60–90 - NCT04867408Recruiting
Using bowel scope images to improve inflammatory bowel disease training
This study uses pictures taken during routine bowel scope (endoscopy) to build and test a computer system for training and research in inflammatory bowel disease. It may help doctors and trainees interpret scope images more consistently over time.
Hull, East YorkshireAges 16–99 - NCT04881084Recruiting
Digital stories to explore empathy and compassion
This study uses digital narratives (digital storytelling) to see how they may affect empathy and compassion. You may be asked to participate if you’re not currently in the hospital and haven’t already taken part in a specific prior workshop.
Montreal, QuebecAges 18–35 - NCT04882488Recruiting
Testing heart scan measurements in severe aortic valve narrowing
This trial compares two pressure-based measurements of blood flow in the coronary arteries with a PET heart scan in people with severe aortic valve stenosis. It may help doctors choose the most accurate way to assess blood flow and guide care during valve treatment.
Bad Oeynhausen, North Rhine-WestphaliaAges 65 years+ - NCT04882839RecruitingPhase 2
Therapy with psilocybin for severe OCD symptoms
This Phase 2 study tests whether psilocybin-assisted psychotherapy can reduce symptoms in adults with severe, treatment-resistant OCD. It also focuses on safety and whether this approach is practical to run.
BeershebaAges 18–65 - NCT04889872Recruiting
Watchful waiting or TAVR for moderate aortic valve narrowing
This study compares regular monitoring (“clinical surveillance”) versus replacing the aortic valve using a minimally invasive procedure called TAVR for people with moderate aortic stenosis. It aims to see which approach better reduces symptoms or heart damage over time.
Huntsville, AlabamaAges 65 years+ - NCT04893603Recruiting
TAVR valve test for severe, hard-to-pump heart valve
This trial studies whether a new through-the-blood-vessel heart valve (TAVR) is safe and works well for people with severe aortic stenosis who are too risky for traditional surgery. If you qualify, you would be closely followed to check your symptoms and valve function over time.
BeijingAges 70 years+ - NCT04896606RecruitingPhase 1/Phase 2
Matched donor immune therapy for mild to moderate COVID-19
This early-phase study tests immune cells from a matched family donor (made to target the COVID-19 virus) to see if they can help people with mild-to-moderate COVID-19 who are hospitalized and at higher risk for getting sicker. It aims to check safety first and also look for signs of benefit.
Valhalla, New YorkAges 18–65 - NCT04905264Recruiting
Studying factors and care quality after severe brain injury
This study looks at how outcomes and care quality vary for people with serious acquired brain injuries while in a rehabilitation unit. It may help clinicians understand what care works best and why.
AlessandriaAges 18 years+ - NCT07692984Recruiting
Alcohol and drug use in people with schizophrenia or bipolar disorder
This study looks at how alcohol and substance use affects people with schizophrenia or bipolar disorder. It aims to understand if having these conditions together changes treatment or outcomes.
Bolu, BoluAges 18–65 - NCT04961593Recruiting
Studying caspofungin dosing in very ill children
This study looks at how caspofungin works in children who are very sick and in the pediatric intensive care unit. It helps doctors better choose dosing to keep the medicine at the right level.
Shanghai, Shanghai MunicipalityAges 3 months–18 years - NCT04961580Recruiting
Study of ceftazidime dosing in sick children
This trial measures how ceftazidime (an antibiotic) moves through the body and how it works in children with severe infections in the pediatric intensive care unit. It may help doctors choose safer, more effective dosing for kids.
Shanghai, Shanghai MunicipalityAges 3 months–18 years - NCT05006430RecruitingPhase 1/Phase 2
Fecal transplant study for severe alcoholic hepatitis safety
This trial tests whether fecal microbiota transplantation (a controlled transfer of stool bacteria) is safe in people with severe alcoholic hepatitis. It aims to see if the treatment is tolerable and what risks may come with it, in addition to watching how liver illness changes.
Houston, TexasAges 18–75 - NCT05012111Recruiting
Study of bone marrow failure causes over time
This study looks at the natural history (how a condition progresses) in people with acquired or inherited bone marrow failure syndromes, including related lung and liver findings in some cases. It helps researchers understand underlying causes—sometimes linked to gene or telomere changes—and how symptoms evolve, which may guide future care.
Bethesda, MarylandAges 2–99 - NCT05026138Recruiting
Study of severe HPV disease and why it keeps coming back
This study follows people with severe or hard-to-treat HPV-related conditions (and some closely related partners/household contacts) to learn how the virus causes illness and how the immune system responds. It may help doctors better predict who will develop severe disease and guide future treatments.
Bethesda, MarylandAges 3–100 - NCT05064709Recruiting
Test device for heart failure symptoms in some patients
This study tests whether a heart-related device called CCM can improve symptoms and daily function in people with heart failure and a moderately reduced pumping strength. It may help if you’ve had recent heart-failure-related hospital care or urgent treatment and your heart and overall health fit the study limits.
Birmingham, AlabamaAges 18 years+
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Common questions
- Are there clinical trials for ards (moderate or severe)?
- Yes. Clin2 currently lists 1,503 recruiting ards (moderate or severe) studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a ards (moderate or severe) trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a ards (moderate or severe) trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.