Clinical trials
Moderate to Severe Asthma clinical trials
Below are recruiting moderate to severe asthma clinical trials, each written for real people, not researchers. We’re tracking 51 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT05691218Recruiting
Early high-flow oxygen plus nebulized asthma medicine
This study tests whether giving fast, high-flow oxygen early—together with inhaled terbutaline via a vibrating mist—helps adults with moderate to severe asthma flare-ups in the emergency department. It aims to see if this approach improves breathing after initial treatment.
Poitiers, FranceAges 18 years+ - NCT04743791RecruitingPhase 4
Dupilumab study for clearing mucus in moderate to severe asthma
This study tests whether dupilumab improves how well mucus is cleared from the airways in adults with moderate to severe asthma. It may help find better ways to reduce mucus-related breathing problems in people with a specific asthma type.
Pittsburgh, PennsylvaniaAges 18 years+ - NCT05761028RecruitingPhase 2/Phase 3
CM310 for moderate to severe asthma despite current inhalers
This study tests CM310 to see if it can improve asthma in people with moderate to severe asthma who are still having uncontrolled symptoms and severe flare-ups despite regular inhaler treatment. You may be eligible if your lung function and asthma control tests fit the study limits and you’ve had a recent severe exacerbation.
Beijing, BeijinAges 12–75 - NCT07372287RecruitingPhase 3
Study of CM326 for moderate to severe asthma
This trial tests an investigational drug called CM326 for people with moderate to severe asthma that is not well controlled with current treatments. It aims to see if CM326 can help reduce asthma attacks and improve breathing.
Shanghai, Shanghai MunicipalityAges 18–80 - NCT07219173RecruitingPhase 2
Study of brenipatide for uncontrolled moderate to severe asthma
This study tests an investigational drug called brenipatide for people with moderate to severe asthma that isn't well controlled by current medicines. The purpose is to see if it can reduce asthma attacks better than a placebo (inactive treatment).
Tempe, ArizonaAges 18–75 - NCT06837922RecruitingPhase 3
Study of MG-K10 for moderate to severe asthma
This trial tests a new drug called MG-K10 for people with moderate to severe asthma that is not well controlled with current treatments. It aims to see if the drug can reduce asthma attacks and improve breathing. You may be able to join if you have had asthma for at least a year, use high-dose inhalers plus another controller medicine, and have had a recent flare-up.
Guangzhou, GuangdongAges 12–75 - NCT06977581RecruitingPhase 2
study of PF-07275315 for moderate-to-severe asthma
This study tests a new medicine called PF-07275315 for people with moderate-to-severe asthma that is not well controlled with their current inhalers. It is for adults who have had asthma for at least a year, have had recent flare-ups needing steroids, and are not taking other biologic treatments.
Mobile, AlabamaAges 18–70 - NCT07011524RecruitingPhase 2
Study of CM512 injection for moderate-to-severe asthma
This trial tests a new injection, CM512, for people with moderate-to-severe asthma that is not well controlled with current inhalers. It aims to see if the treatment can reduce asthma attacks and improve symptom control.
Guangzhou, GuangdongAges 18–75 - NCT07189806Recruiting
Asthma study tracking symptoms over 5 years
This study follows adults with mild, moderate, or severe asthma to better understand the condition. You'll attend regular check-ups at the clinic to monitor your lung function and symptoms over five years.
LondonAges 18 years+ - NCT07241117RecruitingPhase 4
CHEST: Helping clinics use SMART for asthma
This study tests a program to help community health clinics use a special asthma treatment approach called SMART. The goal is to see if it improves asthma care and reduces flare-ups.
St Louis, MissouriAges 12 years+ - NCT00576069Recruiting
Study airflow limits in moderate asthma
This trial looks at why airflow is limited in people with moderate-to-severe persistent asthma who are already on stable treatment. It may help researchers better understand what drives breathing trouble and how to target it.
Lakewood, CaliforniaAges 10–95 - NCT06147453Enrolling by invitation
Oscillating positive expiratory pressure therapy for mucus in asthma
This trial tests a device that uses vibrations to help clear mucus from your lungs. It may improve airflow and mucus buildup in people with moderate to severe asthma.
Hamilton, OntarioAges 18 years+ - NCT07323654RecruitingPhase 2
Oral KT-621 for moderate to severe eosinophilic asthma
This trial tests an oral medication called KT-621 for people with moderate to severe eosinophilic asthma. It aims to see if the drug can help control asthma better than the standard inhaled treatments alone.
Lancaster, CaliforniaAges 18–75 - NCT07245368RecruitingPhase 1/Phase 2
Testing a new asthma drug in healthy people and those with asthma
This study tests an investigational drug called PRA-216, first in healthy volunteers to check safety, then in people with mild-to-moderate asthma to see if it helps control symptoms. It's an early-stage trial to find out if the drug is safe and works.
Botany, New South WalesAges 18–65 - NCT06385236RecruitingPhase 4
Asthma genetics study to find better treatments
This study looks at how your genes affect your asthma medications. It tests if knowing your DNA can help predict which treatment works best for you and why.
Scottsdale, ArizonaAges 18–75 - NCT07330778RecruitingPhase 1
Study of CDX-622 for mild to moderate asthma
This trial is testing an investigational drug called CDX-622 for people with mild to moderate asthma. The study aims to see if it can help control asthma symptoms and improve lung function.
San Francisco, CaliforniaAges 18 years+ - NCT04045587Recruiting
Registry for severe asthma in adults in Canada
This is a research registry that collects health information from adults with severe asthma to better understand how the condition behaves and how treatments are used. You may be able to take part if your asthma is considered severe and is not well controlled.
Edmonton, AlbertaAges 18 years+ - NCT07301255RecruitingPhase 2
ENV-294 for moderate-to-severe asthma in adults
This trial tests an experimental drug called ENV-294 in adults with moderate-to-severe asthma. You may join if you are already using two kinds of inhalers regularly and have had at least one asthma flare-up in the past year that needed steroids or a hospital visit.
Birmingham, AlabamaAges 18–75 - NCT04796844Recruiting
Asthma real-world study for adults in other health studies
This study follows adults with asthma in real life to better understand asthma care and outcomes. You may be invited if you already joined another asthma-related or health-related observational study and don’t have certain major lung or health conditions.
GenovaAges 18–99 - NCT07660835RecruitingPhase 2
A study of nemolizumab for babies with eczema
This trial tests a medicine called nemolizumab for babies aged 6 to 23 months with moderate to severe eczema. The goal is to see if it reduces itching and improves skin symptoms.
San Antonio, TexasAges 6 months–1.9 years - NCT07147049RecruitingPhase 2
Testing a new painkiller for moderate to severe pain after surgery
This trial tests a new tablet called HL-1186 for people with moderate to severe pain after certain surgeries. It aims to see if the drug is safe and works well for pain control.
Chengdu, SichuanAges 18–75 - NCT07582211Recruiting
BPAP breathing support for severe asthma attacks in children
This study tests whether a special breathing mask (BPAP) can help children ages 5–17 who come to the emergency room with severe asthma attacks. The mask gently pushes air into the lungs to help them breathe more easily.
New York, New YorkAges 5–17 - NCT06705764RecruitingPhase 4
Tezepelumab for asthma attacks in the emergency room
This trial tests if a drug called Tezepelumab can help adults with asthma who visit the emergency room. It aims to reduce severe asthma attacks and improve breathing control.
Edmonton, AlbertaAges 18–55 - NCT04160910RecruitingPhase 2
Studying 5HTP to manage asthma symptoms in kids
This Phase 2 study tests whether 5HTP can help regulate asthma in children and teens who have mild to moderate asthma linked to allergies. It may be an option if your symptoms are allergy-related and you can follow study visits and questionnaires.
Indianapolis, IndianaAges 8–18
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Common questions
- Are there clinical trials for moderate to severe asthma?
- Yes. Clin2 currently lists 51 recruiting moderate to severe asthma studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a moderate to severe asthma trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a moderate to severe asthma trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.