Clinical trials
Bipolar Disorder Depression clinical trials
Below are recruiting bipolar disorder depression clinical trials, each written for real people, not researchers. We’re tracking 409 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT07111390Recruiting
Home-based light therapy for major depression
This trial tests whether a special light you can use at home can help treat major depression. It's a 60Hz light that you turn on and off repeatedly. If you're 24–65, have depression, and take a stable antidepressant, you may be able to participate.
New York, New YorkAges 24–65 - NCT07556692Recruiting
Home Brain Stimulation for Bipolar Depression
This study tests whether a device you use at home can help reduce depression symptoms in people with bipolar disorder. The device uses gentle electrical stimulation on the scalp to potentially improve mood.
LondonAges 18 years+ - NCT07576686Recruiting
AI-assisted therapy for depression and anxiety
This trial tests a computer-guided cognitive behavioral therapy (CBT)—a proven talk therapy approach—to help treat mild depression and anxiety. The program runs for 10 weeks with weekly sessions, and AI helps guide your therapist or the process itself.
NišAges 18 years+ - NCT07619092Recruiting
Flumazenil to reverse sedation during depression treatment
This trial tests whether flumazenil (a medication that reverses sedation from anti-anxiety drugs) can safely help patients wake up faster after electroconvulsive therapy (ECT), a treatment for severe depression. The goal is to see if it improves recovery time without causing problems.
Frederiksberg, Capital RegionAges 18 years+ - NCT07621237RecruitingPhase 2
TNX-102 SL for Major Depressive Disorder
This study tests whether a new medication called TNX-102 SL can reduce depression symptoms better than a placebo (inactive pill). You'll take the medication daily and have regular check-ins to see how you're doing.
Phoenix, ArizonaAges 18 years+ - NCT07314190Enrolling by invitation
Blood tests for brain diseases and mental health conditions
This study looks at blood tests to help diagnose and track brain diseases (like Alzheimer's) or mental health conditions. It compares patients to healthy volunteers to find better ways to detect and monitor these illnesses.
BarcelonaAges 18 years+ - NCT07239843Enrolling by invitation
Study of blood markers and mental health in brain diseases
This study looks at how social factors and blood markers relate to psychiatric symptoms in people with brain diseases or mental disorders. It aims to find new ways to understand and diagnose these conditions.
Barcelona, BarcelonaAges 18 years+ - NCT07234851Enrolling by invitation
Brain tissue study of synaptic loss in mental and brain diseases
This study looks at how brain connections break down in people with psychiatric disorders (like schizophrenia, depression, or bipolar disorder) or neurodegenerative diseases (like Alzheimer's or frontotemporal dementia). It uses donated brain tissue after death to understand why symptoms occur.
BarcelonaAges 40 years+ - NCT07217860Enrolling by invitationPhase 3
Long-term safety study of azetukalner for bipolar depression
This study is looking at the long-term safety of azetukalner for people with bipolar I or II depression who have already completed a previous trial of this drug. It is an open-label study, meaning everyone will receive the active medication.
Little Rock, ArkansasAges 18–75 - NCT07151846Enrolling by invitation
Using phone data to predict depression
This study uses your smartphone and a Fitbit to track mood patterns and see if they can predict depression. You may join as someone with a mood disorder, as a healthy volunteer, or as someone at higher risk for mood problems.
Seoul, Seongbuk-guAges 19–75 - NCT06880796Enrolling by invitation
Mindfulness therapy for serious mental illness
This trial tests whether mindfulness-based therapy helps people with serious mental illnesses like schizophrenia or mood disorders. You'll learn mindfulness skills in a group setting at your community mental health center.
Providence, Rhode IslandAges 18 years+ - NCT06823024Enrolling by invitation
Using speech patterns to predict treatment response in depression, PTSD, or bipolar disorder
This study tests if a computer algorithm can analyze your speech to predict how well you will respond to treatments like TMS or Spravato. It aims to create a simple tool that helps doctors choose the right treatment for you.
Sunnyvale, CaliforniaAges 18–68 - NCT06792175Enrolling by invitation
Using speech to detect mental health conditions
This study uses a computer program to listen to your speech and see if it can help detect mental health or neurodevelopmental conditions. It may help find new ways to diagnose conditions like ADHD, anxiety, depression, and others earlier.
Brookline, MassachusettsAges 13–60 - NCT06692361Recruiting
Gut bacteria transplant for depression not helped by escitalopram
This trial tests whether transplanting healthy gut bacteria (fecal microbiota) can help people with depression that does not respond well to the antidepressant escitalopram. You will first take escitalopram for 2 weeks, and if it doesn't help enough, you may receive either the real transplant or a placebo capsule.
Wuhu, AnhuiAges 18–65 - NCT06011460Enrolling by invitation
Observing clozapine safety for bipolar depression
This study is testing whether clozapine, a medication usually used for schizophrenia, is safe for treating hard-to-treat depression in people with bipolar disorder. It may help if you have not found relief from other treatments.
Gdansk, Pomeranian VoivodeshipAges 18–65 - NCT07220460RecruitingPhase 2
Study of an oral drug for bipolar depression
This trial tests an experimental pill (ABB-932) for people with bipolar I or II disorder who are currently in a depressive episode. The goal is to see if the drug is safe and helps improve mood.
Phoenix, ArizonaAges 18–65 - NCT06775379RecruitingPhase 3
Azetukalner vs. placebo for major depression
This trial tests an investigational medication called Azetukalner against a placebo to see if it helps reduce symptoms of major depressive disorder. You may qualify if you are currently in a depressive episode that started in adulthood and have not tried or failed only a few antidepressants.
Phoenix, ArizonaAges 18–74 - NCT07437833Recruiting
Self-regulation exercises for women with ADHD and stable bipolar disorder
This study tests how six different self-regulation techniques affect your body and brain during one session. It's designed for women with both ADHD and stabilized bipolar disorder who have been off psychiatric medications for at least two years.
PoznanAges 18–35 - NCT05850689RecruitingPhase 3
Lumateperone add-on for major depression that didn’t improve
This study tests whether adding lumateperone to an antidepressant helps adults with major depressive disorder (MDD) who haven’t improved enough after trying at least two different antidepressants. It may help reduce depressive symptoms more than antidepressants alone.
Huntsville, AlabamaAges 18–65 - NCT06247839RecruitingPhase 3
Psilocybin for depression: changing self-focus
This trial tests whether a single dose of psilocybin can help people with treatment-resistant depression by changing how they focus on themselves. It aims to understand how psilocybin affects brain activity and self-related thinking.
Charlestown, MassachusettsAges 18–55 - NCT04080778Recruiting
Magnetic seizure treatment for severe bipolar or hard-to-treat depression
This trial studies whether a seizure-like therapy using magnet stimulation can quickly reduce severe depressive symptoms in people with bipolar depression or treatment-resistant depression. It may help when depression is intense and hasn’t improved enough with at least two antidepressant medicines.
Houston, TexasAges 22–85 - NCT04432116Recruiting
Virtual reality training for schizophrenia and bipolar symptoms
This study looks at whether virtual reality and time-based training can improve symptoms for people with schizophrenia or bipolar disorder. You may do virtual-reality tasks as part of your care plan while the team tracks changes over time.
StrasbourgAges 18–60 - NCT04569448RecruitingPhase 3
Brexpiprazole for bipolar depression that won’t improve
This Phase 3 study tests whether brexpiprazole can help treat bipolar depression that has not responded to previous treatments. It compares the study medicine to a placebo (inactive pill) for people with bipolar I or II depression.
Hamilton, OntarioAges 18–75 - NCT04637620RecruitingPhase 2
NMDA-based treatment study for major depression
This Phase 2 trial tests whether an NMDA-targeted treatment can improve symptoms of major depressive disorder (MDD). You may be able to join if your depression diagnosis and symptom score fit, and you meet several safety and study-following requirements.
TaichungAges 18–55
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Common questions
- Are there clinical trials for bipolar disorder depression?
- Yes. Clin2 currently lists 409 recruiting bipolar disorder depression studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar disorder depression trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar disorder depression trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.