Clinical trials
Bipolar Disorder I or II clinical trials
Below are recruiting bipolar disorder i or ii clinical trials, each written for real people, not researchers. We’re tracking 2,361 recruiting studies, each written for real people, not researchers, below.
Recruiting studies
- NCT06396312Recruiting
Predicting lithium response in difficult depression
This study looks at how to predict which people with hard-to-treat depression will benefit from adding lithium to their antidepressant. If you have treatment-resistant depression and are considering lithium, this trial may help find the best treatment for you.
Munich, BavariaAges 18 years+ - NCT04777357RecruitingPhase 3
Cariprazine for bipolar depression in ages 10 to 17
This Phase 3 study tests whether cariprazine can improve depression symptoms in children and teens with bipolar I disorder, and also tracks side effects. It may help if your depressive episode is ongoing and you meet specific mood and screening score requirements.
Bentonville, ArkansasAges 10–17 - NCT07540338RecruitingPhase 1/Phase 2
New Lithium Capsule Study for Bipolar I
This study compares a new lithium capsule (AL001) to a standard lithium capsule in people with Bipolar I Disorder. It aims to see how well your body absorbs each capsule and whether AL001 is safer or more tolerable.
Boston, MassachusettsAges 18–65 - NCT07288320RecruitingPhase 2
Testing NBI-1117568 for bipolar I mania
This trial tests an experimental drug called NBI-1117568 for people with bipolar I disorder who are currently having a manic or mixed episode. The goal is to see if the drug helps calm mania symptoms and is safe.
Little Rock, ArkansasAges 18–65 - NCT06951698RecruitingPhase 3
Testing KarXT for bipolar I mania
This trial tests a new medicine, KarXT, to see if it can safely treat manic episodes in people with bipolar I disorder. It is for patients who are currently hospitalized for a manic episode that started within the last 3 weeks.
Bentonville, ArkansasAges 18–65 - NCT06929273RecruitingPhase 3
Long-term safety study of KarXT for bipolar I mania
This study tests the long-term safety of KarXT for people with bipolar I disorder who are having a manic or mixed episode. It is for people who either completed a previous KarXT study or are new to the study and have moderate to severe mania symptoms.
Glendale, ArizonaAges 18–65 - NCT06951711RecruitingPhase 3
KarXT for mania in bipolar I disorder
This study tests a new medication called KarXT to see if it helps calm manic episodes in people with bipolar I disorder. You would need to be in the hospital for a manic episode and stop other psychiatric medications temporarily.
Little Rock, ArkansasAges 18–65 - NCT06560749Recruiting
Exercise to help thinking in bipolar disorder
This study tests whether a regular exercise program can help improve thinking and memory problems that often come with bipolar disorder. You must have stable mood and no recent changes to your medications.
São Paulo, São PauloAges 18–60 - NCT03829787Recruiting
Study of attention and reward signals in bipolar disorder
This study looks at how people with bipolar disorder pay attention and respond to rewards, including whether anxiety or substance use is also present. It uses eye-tracking and related tests to better understand brain patterns that may affect mood and decision-making.
Cleveland, OhioAges 18 years+ - NCT04432116Recruiting
Virtual reality training for schizophrenia and bipolar symptoms
This study looks at whether virtual reality and time-based training can improve symptoms for people with schizophrenia or bipolar disorder. You may do virtual-reality tasks as part of your care plan while the team tracks changes over time.
StrasbourgAges 18–60 - NCT04917419Recruiting
Light therapy and talk therapy for sleep issues in bipolar disorder
This trial tests whether bright light therapy (luminotherapy) and/or structured education and coaching (psychoeducation) can improve sleep and daily body rhythm in people with bipolar disorder. It may help if your bipolar symptoms come with troublesome sleeping patterns.
PoitiersAges 18–65 - NCT05153369Recruiting
DBT-based care for youth at risk for bipolar disorder
This study tests a structured, “DBT-informed” care program for young people who either have bipolar disorder or are at family risk for it. It may help by offering closer, organized support aimed at preventing or reducing mood problems.
Toronto, OntarioAges 13–23 - NCT05153382Recruiting
Dialectical behavior therapy for youth at bipolar risk
This trial tests whether a structured therapy called dialectical behavior therapy (DBT) helps young people with bipolar disorder or at risk for it, especially with self-harm or risky behaviors. It may help by teaching coping skills and improving safety and emotional control.
Toronto, OntarioAges 13–23 - NCT05303064RecruitingPhase 3
Study of weight gain medicine for teens with certain mood or psychosis
This Phase 3 study tests a treatment aimed at reducing unhealthy weight gain in teens with schizophrenia or bipolar I disorder, using changes in BMI (a height-and-weight measure). It may help families who are concerned about weight changes that can happen with some psychiatric medicines.
Dothan, AlabamaAges 10–17 - NCT05378347Recruiting
Compare two aortic stent graft types for AAA
This study compares two commercially used stent graft devices to treat an enlarged abdominal aorta (AAA). It aims to see which device works better and is safer over follow-up visits.
Loma Linda, CaliforniaAges 20 years+ - NCT05457465RecruitingPhase 2
Cannabidiol study for anxiety and depression in bipolar disorder
This Phase 2 study tests whether cannabidiol (CBD) can reduce anxiety and depressive symptoms in people with bipolar disorder. It may help if your mood symptoms are persistent and you’re already on stable bipolar medications.
Belmont, MassachusettsAges 18–65 - NCT05627492Recruiting
DBT booster sessions for youth at bipolar risk
This study adds short “booster” sessions to Dialectical Behavior Therapy (DBT) for young people who already took part in a prior DBT study, including those with bipolar symptoms or strong family risk. It aims to see if extra DBT support helps mood and coping over time.
Toronto, OntarioAges 14–25 - NCT05669703Recruiting
Tracking mood and activity patterns in bipolar disorder families
This study watches how a person’s mood and movement change over time, and how those patterns relate to bipolar disorder. It may help researchers better understand the condition in families and potentially improve future care.
Bethesda, MarylandAges 8–70 - NCT05802446Recruiting
Neurofeedback program for bipolar depression symptoms
This study tests whether “neurofeedback” can reduce leftover (residual) depressive symptoms in people with bipolar I or II. It may help calm mood by training brain activity, alongside stable medication.
Créteil, val-de-marneAges 18–65 - NCT05837104RecruitingPhase 2
Magnesium and vitamin B6 for early bipolar depression
This Phase 2 trial tests whether magnesium plus vitamin B6 can reduce depressive symptoms in people who are newly diagnosed with bipolar I disorder. It also checks for safety over a short, 4-week treatment period.
Belmont, MassachusettsAges 18–50 - NCT05977023RecruitingPhase 2
NMDA-targeted medicine to treat bipolar I depression
This Phase 2 study tests a medication that works on NMDA receptors to improve depression symptoms in people with bipolar I disorder. It may help if you’re currently in a bipolar depression episode and other mood treatments haven’t fully controlled it.
TaichungAges 18–65 - NCT06081426Recruiting
Ketogenic diet for bipolar disorder brain study
This study looks at how a ketogenic diet (very low carb, high fat) might affect brain function in people with bipolar disorder. Participants will follow the diet and have brain scans and blood tests to see how it helps mood and energy levels.
Pittsburgh, PennsylvaniaAges 18–40 - NCT06197048Recruiting
Nutrition counseling for schizophrenia or bipolar disorder
This study tests whether nutritional counseling can improve body measurements and health markers in people with schizophrenia, psychosis, or bipolar disorder. It may help you manage weight and overall health.
Drammen, AkershusAges 18 years+ - NCT06204705Recruiting
App to Predict Bipolar Episodes in Veterans
This study uses a smartphone app to track your mood and daily habits and predict when a bipolar episode might be coming. The goal is to help you and your care team take action early to prevent a full episode.
Minneapolis, MinnesotaAges 18 years+
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Common questions
- Are there clinical trials for bipolar disorder i or ii?
- Yes. Clin2 currently lists 2,361 recruiting bipolar disorder i or ii studies from the U.S. registry, each rewritten for real people, not researchers, so you can see what it’s testing and who it’s for.
- How do I know if I qualify for a bipolar disorder i or ii trial?
- Each study lists its eligibility criteria — rules about age, diagnosis, and prior treatments. On every Clin2 trial page we explain these in words written for real people and offer a short, optional pre-screen for a fit read. The study team makes the final decision.
- Does it cost anything to join a bipolar disorder i or ii trial?
- Using Clin2 is always free. Many trials cover the cost of the study treatment and related visits; some reimburse travel. The study team explains exactly what’s covered before you decide.
Related conditions
Clin2 helps you find and understand clinical trials and does not provide medical advice. Study data comes from ClinicalTrials.gov. Talk with your doctor about whether a specific trial is right for you.